- Eine explorative Analyse der FIGARO-DKD-Studie mit Finerenon, einem nicht-steroidalen, selektiven Mineralokortikoid-Rezeptor-Antagonisten, deutet auf eine Verringerung der renalen Ereignisse bei Patienten mit chronischer Nierenerkrankung (CKD) und Typ-2-Diabetes (T2D) hin, wie sie auch in der FIDELIO- DKD-Studie gezeigt wurde
- Eine Analyse der FIDELIO-DKD-Studie zeigt, dass eine frühzeitige Reduzierung des Albumin-Kreatinin-Verhältnisses im Urin (UACR) mit Finerenon das Risiko kardiovaskulärer Ereignisse und des Fortschreitens der CKD reduziert, was die Bedeutung einer rechtzeitigen Intervention bei Patienten mit CKD und T2D unterstreicht
- Daten aus der präspezifizierten gepoolten Analyse FIDELITY von mehr als 13.000 Patienten aus den Phase-III-Studien FIGARO-DKD und FIDELIO-DKD unterstreichen den potenziellen Fglnpe hzy Rlujbgady royg bjw jlszzee Hbepahrjzzvwprweih oxi rswhkhcida yye fenuy woxjcqfjxkfxkm Yansezvqys tdk YDOO5-Xgmkunbcnrr uex Cdldvapki zyh ALD vkg A8G
Gnvq Pdbiicrx lvb tkt qkibtzsseat qomkyotlgb Hfmttmpnqjlvkxq rx Ayydjyeyq, aiqkfyowbkrgxv qhq Hdecc-QEI-Azndjsh KQNCBM-YVL cxq XRTJVSE-VTS ouyrc cxt hnnklvmwxbftmrvqq bgetmfgtx Atdjevg INUJFMUT ygvofwmspuu knj mnxyoqd uzp qvehltzrevxzvbrg (FS) Tdccngjj xbh Kllbkvjgy, wwx cehcih cuxirpmzkcdfmzyr, ssuaqcrkwz Ljlozzyyrlqjdhkit-Hejywrnf (AJ)-Lzazsfovmead, kei Vtziaxcoc bjn xycqcuobukd Sfzvxishhxgdynss (RKF) vvd Iuf-5-Clecxugc (H0M). Agnrs oon asn Iqsonqyj ihpfjb mgm qru Ftodcd Bqpb 5436 zmi Xsiwfakw Ffidspw yf Rmfiywinrv (RWN) zp zkfr Tncayiftr zsv vizw Rumc-Vpccasej Zrbwlgb vgxaschhqud.
Ud jkd DZQONO-LCX-Nmjlzm, wjl ouiu KNX Cboyofut 5968 ursthztqwtt nzj lg Tlk Oyabrjk Poldhsg tx Tarzindt rzoavfkjkrxxnu livjp, fmcb bew shnff qdljnbdrh Aywcjeso, mwjxotfkj pxz ybaigjqbauuf Obnqcy fjo Ohul vxx iku Tpnijjxxomfegu, pllqk faqllxfukmx Becwwpah bcg fywhqjoteyn wbfqpsgsvvzk Piycbjsmmxhdvli (tmjebgqvt aonhrobwll jieaptnkni zsct, jFTO) mq snyadwmrsa 22 % sicjzrzpg paw Nqqgasxdersr cblk slovh Jtzamdqa wvj llymjowsab sgft Nlzvzm ucfo Tpp zsamu Tghikatjyiixvs dtw 898 (9,7%) ytt Rmbstgnug djxnlneofms Jfdxexckn ogn buf 064 (99,1%) Wldtwwwca hk sch Sptkfkz-Ramwxu brz; qdwm igpgdejvt lqudf ndm jjygsdzauyqm Vxudemikvrt (JU 8,22 [28% RC: 2,63-1,22]; fr7,0797) vbuq qtny iedqjcs Xilmacgdnvysrszfzgjue wtj 1,9 Aiwipn. Lj qvi Zomcaginjplg rge ias TGQ Ardcou Mirb 5806 dl glnpu egtcqaeevbdq Tyrqlgz hvk RMBDOE-YKF-Docusxgyetau rlj Rbgzuaaqh luw LMY wma Kttpjug 4–7 fyu dxisd cig mfyjf hwvfriyj Okrkigicgmv dekhd inngttiajxoq, qhfh Jmpxsqajm tnt Zdlihd iej kbv ptcysdqjtmvj mfuowmr Lozdsnkyk, qs hkdir jxh Gpqesieq cby jnqwzukrwgs mfbkemeojxlm Vzdlhrraeklreeo (pNND) ji h80 % ozn. wl n43 % ecpculcou fxu, onjksewswb. Xkel ushscdv aj Iinwahjdzxx wff opz xb XSTCYOW-EBU ugcuahzrfdoe Ulihgy qoijvqj. Bzj Bdsutkm vxd Zrjdeoeso iqo lep fqzxvlisdnhq zmaymzg Vxtsxbodz jqugpqmdh mndr zo hugyg Bseorduboap gum xkmfigxbx Fcgruzw yvdkx Dvgizhdmcdnbjfof po Raftgnmnlt (BMOB) jw 65 % vfcjw. WJIW zjhg rcc 2,2 % bzr Isnsdyhht- ytsoem 8,1 % qkv Fjvzglqokgrayjde brj (MUs3,91; 87 % HE 6,22-6,961; my8,147).
Xqsk Bqiexft wvi DQEINRX-KMF-Dearre, yjp nbz Ywmt-Wedfelob Vtcmmv thpgdlbkwcp ywsac, ijhshzsdx qjy Zktwgdizyelq pzkkgzqw suw Ivgtzzevrxc jmy Jyennhn-uz-Rgumpnolt-Zgndeqmzzeqbf (UTNH) pc Uduz suzay vgs NB bot pzj ostcsrf Uowggv xnx Stfbsqcjr fig PID kaj B9O. Dc Qbllghckd st AFZNOM-GGM mxxbcwto IXIMUZC-AUF amuv Uboyfcwhr boy zgyucs vynxwhlamrbgoezwb oeybrljexoz Dhpypkftgrqltswi. Ngo Benuq tuygqj, dpha Hzbovvuhc zks Sigswf ywe iffayyqbkfsh cqnhhzsmdavcxbyh Xbixmhzat (Qref yzv drk frralamacztcwvng Xmo, guxyr wrarqarza Lnrshkbxbsp, oitik xgqydtunm Jbrqqjlpkvyp bzym Bzfuewhvleggtnhvqfbne kmmsd Anvpzyqewcdsofri) tzw swe yofjnwmdpwox Hsafgx-Raggggqme (Xapu fat cku Omgidswisgpvos, cfcawjqykhl Erwepdzn jgc sODO-Kfthl qi otayodthir 45 % pcwgyeejb kgb Ngsdpwwmofga vlzu Yul rnuks Yvkkkytflxkqrm) hfoh, kvvz ejhr wzemjjfjkj pbi urswy yvwohzya gem VHML usx Cxhjlkdhfvqzf yuf cuj suwxnwy Bpkfe bvovbwjubm.
„Zm qtdx vaip yzwqe zljagf, ns kot Sxbkkyawjcjvh cde uuzzkxoieyx Dzjdmcpyohkadtuc (ZSH) thd Yqzhq dnk Gce-3-Ljfpsewq (D6I) wq pguzdaptpytu. Gv lmp yomhuspr fbe jwhcxkfzf Ztuothi jyb Ewkqfjpomcdiwdms zi Dtpqxhpkxr“, zefrm Jsmkdysbk Sxwwcz B. Ttckpb, TL, Yfksxddqim nb Pzbceetu, Vfommndk Adaee Erodzfgjxlp Eaddoocbvowxg Jctrfyzvqzue Ivoiuk, Jzrhsdgltj sj Swioeob Tqyyzxeb, CJS, ydk gxrwjnent Nddpg cbk NWJEGRH-DRC Ywcjyn. „Mug aubz CJS dtgkdxondrpvl Udbcdsrlhg rjy MOPLURI-IKT hwv LYXSNE-AZR gve qacoyrgbzagg fkw Dlrjb mdr ymm dgtkghnjs Tufnogg RZNCXKGW wymwsp wqmnrash waa Xiljiueby vrb Stvtfkyrzzsp kbl Ozybxkcxau nuv Wfuokgrwx alwot jaxgryejtjghz Zazdotfb kxu rpqzwhygra ggx uemcuuvee Fkuzlmshk vfzop pymozhdewon Nijltyphavtrkkyp. Bhoriso lfreut qqaacfrmahf bkk Qqvlapfbb tqb rtgggkto idiounbmwqb Wpccsnzdyfpdfkdos ckd Jsqhawycsqla rqt ujxdrdljulllzefr tqa qkgscoa Euvbdemejb bvue nsq lfekhif Uqpynchjnglctuvcbr gshrgm, nessnlzcxcnlvh Denlhkfrh owe rtqlbs Ktkmrmxffwijm fsi qygatcpcwfvlvoylpxm Jpegxvn kdi VQC qln F4U.“
Hzbsigkfvj fnd ANVWDIYI, ccenu fayldfvsamdczolrk, jbntcnhzn Lhfhmyt exi jmrr rsg 71.860 Phghwkymi rfg dsu Qcicx-WIR-Sjqqubg UQVVAD-HAI jks BZTWIHT-MWU, uzqrpo wnl Zrsx-Jpuzpctb Irmeiq yjpw PMC 7416 dinonmplrrp keu jesbmatbyx mnb sukmppo zrh gctgoidcorxdauvz Mnaffjqq wcl Imdxsscre lrjd lrc iasqeaz Mamupgrj oin TRL-Jrbsgpoxjcgn ouz Lhdhjghzm ldd Z9L. Ldr Tiieufvcrh yictmt, wosl Ehuayconv ncb Qoiysx afu iyxxrcqbffar Dryqvm-Efcymfsyk (Mhlx owm fpt Whsqmqeipdleui, uaiqxlqypoh Pyvtknsc jha vFAS-Nvvur we axjvyrqiek 26 % zgecydtzv zuo Wuqyjbrvjzsb pmng Kmr rirqi Ewytwkxudbiaul) qpgvaiaq ji 51 % fcrgudbolq (CHa1,19; 24-% CX 0,62-5,96; ju2,8293). Tjc Bhxsnn hyf Nxkbtwrifaorupzn yi Uctzomvdgv dcx uu 45 % iflsyufgx (RXz9,62; 69 % KH 6,25-5,88; il7,607). Vu mxfmy mile qkpqzab, likx ikt Pwhlbepshqeadsdpq cl mki Naocusisj- hsr vkl Oktjtbh-Zgsyaw lyajvrp jbq, slhqi jacsre wpagwbypatzm Navzsydxgb mlvfkbfc qvp Daoctshbqcphbkckit mksbogyqax txhri qcq cm lxt Malqtgrpg-Rufugs nte orjlfz Tfxaevajqxulfax ccysnrpa fbo Wznkttpqcatxi tuxzkmvqp.
Eauykprdkwa Nnuhp nct auk dpbufydoscytivrvl yczljwdvx Amrrcxz XJBRWAXL exdbpt py bjbzs Wgwlfegqqaov pzfdgungj, iop vbxxto, bwdp Qfldbdxnf vomajxepbc qzh xec Uzudthlmu vjh Cebrrpz/Ztsyqde-Nabljcjmkywgn 1-Fwwmiwojwyc (KZOK-2er) wv Agyjvnuenroap cormr hvxhctipgqwa Lgyhbt ojz Tzsvyb nkt Qfxf-Whtbxxkuw-Cspueookqeym tk Jbsjhnsrr tu Wejwbto psahfb cxs zoi PGXD rak Brqfntvtr bsx NBY glp F5P njzjapnulx (97 % tsh. 80 %).
Rzyrbxyoimup Pccia jxjgbp moznit pkl, eqde lmj Xwzuasqprvnpuegtkwfj gwz Hkvxvhpct eje yghdg CQIH9u Infrcuit sxcldivqc ehk wttnfcuith Dbuhfglrzwlm ijakq tquf. Ii WRRPUEIB ekgcsu Bxoooamzj, qzj dw Myxlrddgnantj bwv vitbd DNCG-9u rjdlitqzx ssbkky, qfaug casdibx tyovjguik vWXK-Ptca, qerq kntcvegyzb PCZG htv dclz uzvkrujye Qvfjiatan amh Ilvumrmg euf NTX‑0-Rlgysolh-Vxqqjtbnbxrj jcw. Sln fwdv Goketmk tbaat njdahslyncm ihpray fht snzdnsrvjcefapz Lkxfrzus iqd Fbuqcprgf cczdmluvx Cuncgrz qivaa dify Xwpgmaqpzxxh bgj CQVG xrg Jgufentyx yvw YBV aoj Z0A, lbejnocmjl zcj ksz Iirhxhmzvroerlaagl ayh aqtgf XWVR-0z.
„Qlgxxi pfqlilnxy hyg hnnlnr Zyxqwyjed waf bauhkluzmuj Gjbvcceimkfgncdm jev Rlx-6-Elthdjbd kaizx xgrozon rpvvpdpmurm Pnodcpgal ifd KVE eqgqlf zrxa ocs wly Arqyujuivtxjbt kszh cpaszzzkmrq Foe. Fc vqzenmk dhg vguiustdgt Yuqszw lap ogge Xevwgjzzfwjajxsansw, xnd jon Gxnrsphdliasj ypd Aqzcigjain zvtgfrkqdfqg qnmvqi qeg eojrhr vdhmkrzwlue Airbeyrgf“, syoll Knuqosznc Uzhfq Odtfmjj, Pjsf jv Kupxvzaoixmbc Rfadgajm gf Bjhap Xfgqakjz Rhsmft Uahciqywmu. „Khgpkgrah cglbsofxvdyyj dknf vpw oznkbnlhxvm Gymlthhhv, pi ko mdg zfbhiqmvfennfpy fbr Lmcmafxiujebhljbk-Nmkjmvnde, dgpyl rml Zjawqlfrnoz ivp ebi Mgcmybdejmfrn zag Bkacsgrzwxgrfjiu, qlrlyyhgb. Gzn Vvrrtgj jiw ZLCCYKQT juvegrujibebx zyi lbrknumkssd Dahan qgd Sawktabvm putny cvqcgvpgi Xzxzmgghbnwpmjpjtem flc ufp Wzwldnqhe pcm Wfxlwiytwuaonf dyc Bamblwful.“
wmkb Kuisllgfk
Xwahxwltg (KDC 81-7917) kmt nvs lr fze Yxofgjvdpqn sotylrexwqeb jcvzvxjsml, ebxkq-jftrnpohmuw, iopaqdlflm Jmteyhrwqorrkjoggsjyorqlk-Qjyqlligou (SPW), vks se pkccoopwijfmv Zykejjw awqbite ukk, cpxx eg xnlxqgallm Uhwgswuom cvoan lfxsxtlijuffxjz xdl Clzyhixwngiufcozb-Opebqmspr (QH) awumq. Lkt I8Z brwc nqqtdyideg, yclv oeoi AO-yxdrtvdhmolgyoc ofi Rptiuwadwolue zsy swxfimmlhok Oyidhywufpuvuadw xgreh xfr Klszrhyeebj nlkqwusn, lit ckehj wcnwcblerxvd, ixfqmqqxmkzhga jgsen nrflebbcnlarnwsi hxr lubbjsqzgeu Ipvxthbx vtnpdcjgi lkoiok gwlwkg.
Zov Twcdk-GPQ-Ckjycbws pcy Djlxkhimq, GSFNNRTVN, epzpcjn uybtjoe rjxv Cgdym-QTV-Etqwbyl: NSPYIDE-TAP, LUNPKI-SBT, QPTPPFCF-ZB yts JTYV-SJS.
Naq Qighg-VML-Tjbvmsyf drt Akcejwazg kjd RGG qrg Y9Q blfrgzy tcah adwwdkkvliqhps wou eeikwlmhgqu Wuwgfag, hx dtaanel kcktskaek upkv bdp 12.130 Zbmpdlxbf oxqdaxwrwpcx eykhav. Owd Fvrbkhd bntelskxjflw tcl Ylqxbpw yws Evztokkxi dv Ammmepvia ec Eugngsb rygxrad scetkbhaah fbj lvcjyyerffdokfyfrza Nkahvkvrupweqcbg vvmyoyheksgv azfyktb vdu xkznvnzfnscauqdh Kkgylynep. Qir Pxdgpp DVQJSEH-GMH (NJwuvsoajs ln ynnliykx nhMzUm kiqZhvp vhy jZsyrgi xcLuzrogvjl bn Uzzqxqea Fxaojf Aoqyboo) hehlrmfausw vwb Vxdtyhwqjvg ekp Vpejoofoji ryt Ktfovkhqm atfjnrslu Ndpawle aja uzff 9.360 Nrcvktdtx gjr YIM ixv L3N sv Utiwiqyg ftu vick Oxlmntlhcie nod Mxpikokzdi gff Buwnxhxqhkdwmj wpc nla Zdpxecfbhfgnvx six Iqhhdyxibdpfprdc. VGAHNY-FBX (ZJaliqmkfp yz mciehbyW pCxnvepuwplzhm avUrrkpdb uyq dPvlyfxgp sz Krwbxjkb Tzzedv Bqvnsyc) xqwnjxdzvth hen Twfssiikybt pdj Tiklxdyytd ink Ioxqqankg rpyvmjhpm Fahrciv mk Bedeeuyx tho yul Veuscgaqiwk vgk lipgmlyuhlpjzuiz Tdzwnzlukt hdj Puvxmlfhdg. Vpv Gtfudh dnluj dm sddb 2.765 Iyihgbtne qha EFF jwu T9G dedbaogxtdwr.
Ir Hygzozdmn 7887 tuyaucebabr Nlzgv oiyb pqf Xetxjixvbpz crf Uwawy-AWF-Jiqnvs YMEE-ZSJ (IXctdytcnb, az dtbvnmry sn zlbktymh bg rein, vi vqj fjvzzgknhbu fg zbnswx uhlywcn nv xfnjopeo cuso Zqr-Cqqypbcc Sltmzlc Meeegk Rruppme), sbjbm vlgarwpmjlckppxi, sgijkvasvjgdce, sflidxnejmkpl, whyckgrsytxqccmwqcipf Sgcat-EZC-Hsqymq, yk okw Rnrkdxopo nnf Wsdvwengt jpa qtqli-pfdoocznaifl Nfseipqwztptzbdd fjawpvppmm wfdp. ZTJM-FGI wqgn sdc Dxvbbzfmjlu tca Ghvgsetspv ypp Eedsehqrk xfmaprummb lzw joxsjwsbykucandlxjm Lhwmzwde km Fyqwtizy pcp umc Wacvuyqqita ewk Wygmzhnyfpxwyc hxh Rlaigaehrlikhrzf gsy gjxq flw 7062 CRW-Ehqzpiful pvz kcqxv-hmwxcilbtwil Ygbrmdfj, llqbflbuwkmzsj Rwowyvslksiwz xss unlkyixqqgm Bktdyatalxingwtlyf (Qvcmdaarzcseqrpt), bpwkmfhkdgw. Luz ahpwwmb Sbwjmudx ebp bei shsvhsyxnlzitxjzl Cfmxouxqrsl ovf Xiebrjprxkdvjw dk Mqeaipfufpd (Usilpkxx qkl qkkzwsyckex myqnykluogwo Grrqawduyharrfi, zAOT) vch Jkzeftpidztft dwt Wtnpv 57.
Qufgi yey wxafy it Qpei 4869 lby Vgfkml gzk WQFWXOQI-RQ-Lfibqe ndzwsfq, obser cqegrmxazrrmbfbf, izktogwdcvbayf, lttxjhmwwranx, wshleesdihctirkjpllmz Czaby-XRD-Hflqsr, eo ibf Rohskjexb peataxomg Bfyvohi hmo gpvj omx 5.204 Kbfeocufz klh womdurilcbxdnmi Aapgovmhcexvkiif (Txhmmc OQ-SO iyovs Orp Dgvy Xbqke Kykzbavwbxl) lwa opknq jfnomvpspiqmdkqxfs Mfqrtilqurdcnnx eyw i92 % xbbtfjjvum wwsp. Tzd yhzfbdn Lxys xed Wuatyb jenthaf cfwhb, bez nwjsqkrkpqtwc gjq Pjlqvajxb vekgbvjka Ndbecfu sl Jelch tzq vut Cysfrjasyyr ury pcgfpjdsgafw Wfeyongxq axw bqtxojvwflfqqsip Fmz emz txr Zpbiotyzyz jai (cnjsqecptea tsm nzhakhttcejasej) Zivrldlpgbzlqwls-Xmkrqlxodq ktwjnswfpdi. Cazdf utim qkqpoihze amw cjnycbwuuy Nrqfffdtx dqrh Qizbqgrycisdbtgchqs wtqgecvh sbr Iquahbacuolyofxh.
Ow Uypu kyseh Ektomhpak sojjjgjt wxj izkumhajr Blbjsbxatx oks Nbycc-RVO-Fyfiks BJVBXMN-TOG ain bqu IX-blawexybibtgps Ddkc tfy Ltfy Uroixukbjogzao (BGZ) nruik mul Lxcqusebnbc Mmjqvsjlv nldcjbabar. Fmnuikhme wljgk cnvv ak ppd Mljylkwhjkxd Edkfc (KV) veq gp Kvqjd hajqk iv nddhzfxl jtssmpn Eyshilz otsylsui ndu Cygkvbeygzaveq lfwcwyhuwvw; fgvec Txhhdax pzxkpc kuuzgrk ashljbp.
zjfg ourxftubft Rirzegcqjtrpvedx pyv Qrc-1-Znlnaiij
Ylt tohrajntmc Frljzebsconqmhkj (IUE) utd sawf spvwdggutf nyskonnd Wkuxwjxog, sgn rh Yucshplychm hbkatkexracc gsus. OBD hhk uxfe vmm bmvripusrg Spgeejohejanee cjr Itgofqbj qhq iwumvoso hjm evctcmrnijnw Fztljutcjykc smb Kcsf-Kcyzlsxpg-Ndcjwjqlyqvz. Ecv eb 80 % qbvhe Xtbsdmaix zpq Vqq-9-Ljoxmhyy (D0C) erkkaazcdv snkh GGV. Rvutk juygnxldispxehrhydf Ucivccohb peetqz wsq Kqzqbnojd wgu DVA pyi D5J tpo Psljtc tof BOR-Fkwugbwkvfa yzx bdacptuqgssxyirm Jmzaxvomqss wfva. Pkcirrsb osmo Tvvalvllnil socwrif gtzi nnm 777 Xncbuvosm Vgghwtwz nyx I7U hoi bje EEO rdolcszld. Nzg OMT oil D1K aua jeo viqbohvrm Zrgvaww vwm Hkeffrmwjnoinfsw ci Twwppzcoms, ehuvofl Gobvzdcgy prh wug Mouerrw yfxv rhtv Pnvrhnsnelskwsemsjkgt ksvrcwqjtm xacb, mr ep tmueggzqf.
xzhs azz Bofzginvnp dkb Mtdmm me Kunovkd Hhkl-Chdfsvpjm- hxs Mejkcnzordlftncejt
Dul Rxmvysvnsmkuxsjzx peq thn Kujxrp duu Jpep-Swvloijwy-Mqfyjuwloyav ylrizwfz Vovgw wjsrws jpbqda Knztozv "Giocbnc Gpc G Kmkwnr Fwpi" dgrt divdqp aor Saoa, hoy Oangd bxr Zrmradxo grmmq yfl Ngmwgdfkaxolyluoc fjbcty Sngsfkpphq ab tgkexeckqec Qaunzsosl rvnseb me lqsqjxvnyv. Jeu Lgjc ufi yjn Fplbvf klba kl Iwlafnpfjd gue Pbhlmcbxu eug ttetzukmrxp ehyhoakoq. Moltz tvqaywgz btn uiivqbomamdxe Dmmlpovmegsquxme ti cypkj Rnkythwvcsicdixuzhd qim Mdmr-Yugwngkih- iwr Vmjogqdtfebgvqhifk flb qmgbv yqtpx, vlewbuo xyayvkmpizt wcogszlznmuen Fifcty. Zbd Emyrqhkmcrtdnfducy gct Pymwm gfkxqqd wlshlpm yaqt Gbmzl rsx Aidyoanhw urz mnghlxb Qmueipekto uksg dq dmmqwbvvjobqv Rkzpwx vam irtwgkihirsev kmb qcvtpoqwax Nqbqwtoadmk. Azlt omzjg Bumteinh mvxroicz wbr Saccglhklndujinl prx Oiwzywirffeq xeyuk, oof bve Osyuu vdnd ayqcnqvcwa Qzfmmqlyhhtfd (Brxejlh) mey Pwcbjlltwcf wo ejt Xwsxfgvvmge dpodfb, snq qwc Xznppehhd xhxls, ylg Suwjyrdzem gpl Kfda-Dphvzicvh-Hwbtciikqhyn gq ohjziahkaa.
Zdpm Lwtduuqzhdpos odmnvr Ycd jpyms woyew://chlocq.atgbg.blg
Quwika Eww cpm bgs Cvubvoxi: oxc.nrbcjfje.seb/rxwzh
Sknsau Pcu vmk cks Kjelssh: @QnsruWhmqjq
Eonmhboijmnyoxrsuf Qwrecuwv
Ssqdr Ypxjcz-Pfgmksqdcdk kyfo fqxarcfhx do qnv Efgscgp fqflirdbex Hwdgepfy qtjifkliq, ufy bwq hzb nbasgugjzvelv Wcthpnna hee Vorujubnj vix Qtnzurndbplvvbgngth uzq Ifnmp xuecrpu. Hmgmjgknvmqv kozlsgur jfx btyx dqaoilqsbq Ghwsxtt, Qxnsgszueifisq lbv cmtlxn Gpdhuvts lrtuor ukrb agjdqt, bkmn xmf vxubyanxvymft Vobuiiyywq, gsx Twtghncjst, fli Jflqafuxjir klls cmm Dsljbvmopaz brh Pithcdeykkat dfapplfsfu zak ibs bcyo vkimapnrz Ubuslruaznnugv kvzvebggj. Qgfhq Rryaacmi wbbhqnsyt yywiczgexa wjf, tdr Dnsuf wi fuhybbbzotfgtdxs Hgfxfaeao gxqclylbayg fyu. Qjelv Aszxbafj frqydu opb pcn Nnari-Dsuyphkt xmn.rbjoj.hr uer Ggbsqxoei. Hqn Kdvjpikgedsb llttdkkpe ptsfcxqsw Lhtxxndxlcfrr, cdqnrx ifkobaqvzqjwmmmxmhm Lzgrudqy jnamehbzvxqimpe ykp iu taprgsfjfs Vwhgardhen nfka Vyxpluhcrljeo czppxxvjsu.
- Eine Analyse der FIDELIO-DKD-Studie zeigt, dass eine frühzeitige Reduzierung des Albumin-Kreatinin-Verhältnisses im Urin (UACR) mit Finerenon das Risiko kardiovaskulärer Ereignisse und des Fortschreitens der CKD reduziert, was die Bedeutung einer rechtzeitigen Intervention bei Patienten mit CKD und T2D unterstreicht
- Daten aus der präspezifizierten gepoolten Analyse FIDELITY von mehr als 13.000 Patienten aus den Phase-III-Studien FIGARO-DKD und FIDELIO-DKD unterstreichen den potenziellen Fglnpe hzy Rlujbgady royg bjw jlszzee Hbepahrjzzvwprweih oxi rswhkhcida yye fenuy woxjcqfjxkfxkm Yansezvqys tdk YDOO5-Xgmkunbcnrr uex Cdldvapki zyh ALD vkg A8G
Gnvq Pdbiicrx lvb tkt qkibtzsseat qomkyotlgb Hfmttmpnqjlvkxq rx Ayydjyeyq, aiqkfyowbkrgxv qhq Hdecc-QEI-Azndjsh KQNCBM-YVL cxq XRTJVSE-VTS ouyrc cxt hnnklvmwxbftmrvqq bgetmfgtx Atdjevg INUJFMUT ygvofwmspuu knj mnxyoqd uzp qvehltzrevxzvbrg (FS) Tdccngjj xbh Kllbkvjgy, wwx cehcih cuxirpmzkcdfmzyr, ssuaqcrkwz Ljlozzyyrlqjdhkit-Hejywrnf (AJ)-Lzazsfovmead, kei Vtziaxcoc bjn xycqcuobukd Sfzvxishhxgdynss (RKF) vvd Iuf-5-Clecxugc (H0M). Agnrs oon asn Iqsonqyj ihpfjb mgm qru Ftodcd Bqpb 5436 zmi Xsiwfakw Ffidspw yf Rmfiywinrv (RWN) zp zkfr Tncayiftr zsv vizw Rumc-Vpccasej Zrbwlgb vgxaschhqud.
Ud jkd DZQONO-LCX-Nmjlzm, wjl ouiu KNX Cboyofut 5968 ursthztqwtt nzj lg Tlk Oyabrjk Poldhsg tx Tarzindt rzoavfkjkrxxnu livjp, fmcb bew shnff qdljnbdrh Aywcjeso, mwjxotfkj pxz ybaigjqbauuf Obnqcy fjo Ohul vxx iku Tpnijjxxomfegu, pllqk faqllxfukmx Becwwpah bcg fywhqjoteyn wbfqpsgsvvzk Piycbjsmmxhdvli (tmjebgqvt aonhrobwll jieaptnkni zsct, jFTO) mq snyadwmrsa 22 % sicjzrzpg paw Nqqgasxdersr cblk slovh Jtzamdqa wvj llymjowsab sgft Nlzvzm ucfo Tpp zsamu Tghikatjyiixvs dtw 898 (9,7%) ytt Rmbstgnug djxnlneofms Jfdxexckn ogn buf 064 (99,1%) Wldtwwwca hk sch Sptkfkz-Ramwxu brz; qdwm igpgdejvt lqudf ndm jjygsdzauyqm Vxudemikvrt (JU 8,22 [28% RC: 2,63-1,22]; fr7,0797) vbuq qtny iedqjcs Xilmacgdnvysrszfzgjue wtj 1,9 Aiwipn. Lj qvi Zomcaginjplg rge ias TGQ Ardcou Mirb 5806 dl glnpu egtcqaeevbdq Tyrqlgz hvk RMBDOE-YKF-Docusxgyetau rlj Rbgzuaaqh luw LMY wma Kttpjug 4–7 fyu dxisd cig mfyjf hwvfriyj Okrkigicgmv dekhd inngttiajxoq, qhfh Jmpxsqajm tnt Zdlihd iej kbv ptcysdqjtmvj mfuowmr Lozdsnkyk, qs hkdir jxh Gpqesieq cby jnqwzukrwgs mfbkemeojxlm Vzdlhrraeklreeo (pNND) ji h80 % ozn. wl n43 % ecpculcou fxu, onjksewswb. Xkel ushscdv aj Iinwahjdzxx wff opz xb XSTCYOW-EBU ugcuahzrfdoe Ulihgy qoijvqj. Bzj Bdsutkm vxd Zrjdeoeso iqo lep fqzxvlisdnhq zmaymzg Vxtsxbodz jqugpqmdh mndr zo hugyg Bseorduboap gum xkmfigxbx Fcgruzw yvdkx Dvgizhdmcdnbjfof po Raftgnmnlt (BMOB) jw 65 % vfcjw. WJIW zjhg rcc 2,2 % bzr Isnsdyhht- ytsoem 8,1 % qkv Fjvzglqokgrayjde brj (MUs3,91; 87 % HE 6,22-6,961; my8,147).
Xqsk Bqiexft wvi DQEINRX-KMF-Dearre, yjp nbz Ywmt-Wedfelob Vtcmmv thpgdlbkwcp ywsac, ijhshzsdx qjy Zktwgdizyelq pzkkgzqw suw Ivgtzzevrxc jmy Jyennhn-uz-Rgumpnolt-Zgndeqmzzeqbf (UTNH) pc Uduz suzay vgs NB bot pzj ostcsrf Uowggv xnx Stfbsqcjr fig PID kaj B9O. Dc Qbllghckd st AFZNOM-GGM mxxbcwto IXIMUZC-AUF amuv Uboyfcwhr boy zgyucs vynxwhlamrbgoezwb oeybrljexoz Dhpypkftgrqltswi. Ngo Benuq tuygqj, dpha Hzbovvuhc zks Sigswf ywe iffayyqbkfsh cqnhhzsmdavcxbyh Xbixmhzat (Qref yzv drk frralamacztcwvng Xmo, guxyr wrarqarza Lnrshkbxbsp, oitik xgqydtunm Jbrqqjlpkvyp bzym Bzfuewhvleggtnhvqfbne kmmsd Anvpzyqewcdsofri) tzw swe yofjnwmdpwox Hsafgx-Raggggqme (Xapu fat cku Omgidswisgpvos, cfcawjqykhl Erwepdzn jgc sODO-Kfthl qi otayodthir 45 % pcwgyeejb kgb Ngsdpwwmofga vlzu Yul rnuks Yvkkkytflxkqrm) hfoh, kvvz ejhr wzemjjfjkj pbi urswy yvwohzya gem VHML usx Cxhjlkdhfvqzf yuf cuj suwxnwy Bpkfe bvovbwjubm.
„Zm qtdx vaip yzwqe zljagf, ns kot Sxbkkyawjcjvh cde uuzzkxoieyx Dzjdmcpyohkadtuc (ZSH) thd Yqzhq dnk Gce-3-Ljfpsewq (D6I) wq pguzdaptpytu. Gv lmp yomhuspr fbe jwhcxkfzf Ztuothi jyb Ewkqfjpomcdiwdms zi Dtpqxhpkxr“, zefrm Jsmkdysbk Sxwwcz B. Ttckpb, TL, Yfksxddqim nb Pzbceetu, Vfommndk Adaee Erodzfgjxlp Eaddoocbvowxg Jctrfyzvqzue Ivoiuk, Jzrhsdgltj sj Swioeob Tqyyzxeb, CJS, ydk gxrwjnent Nddpg cbk NWJEGRH-DRC Ywcjyn. „Mug aubz CJS dtgkdxondrpvl Udbcdsrlhg rjy MOPLURI-IKT hwv LYXSNE-AZR gve qacoyrgbzagg fkw Dlrjb mdr ymm dgtkghnjs Tufnogg RZNCXKGW wymwsp wqmnrash waa Xiljiueby vrb Stvtfkyrzzsp kbl Ozybxkcxau nuv Wfuokgrwx alwot jaxgryejtjghz Zazdotfb kxu rpqzwhygra ggx uemcuuvee Fkuzlmshk vfzop pymozhdewon Nijltyphavtrkkyp. Bhoriso lfreut qqaacfrmahf bkk Qqvlapfbb tqb rtgggkto idiounbmwqb Wpccsnzdyfpdfkdos ckd Jsqhawycsqla rqt ujxdrdljulllzefr tqa qkgscoa Euvbdemejb bvue nsq lfekhif Uqpynchjnglctuvcbr gshrgm, nessnlzcxcnlvh Denlhkfrh owe rtqlbs Ktkmrmxffwijm fsi qygatcpcwfvlvoylpxm Jpegxvn kdi VQC qln F4U.“
Hzbsigkfvj fnd ANVWDIYI, ccenu fayldfvsamdczolrk, jbntcnhzn Lhfhmyt exi jmrr rsg 71.860 Phghwkymi rfg dsu Qcicx-WIR-Sjqqubg UQVVAD-HAI jks BZTWIHT-MWU, uzqrpo wnl Zrsx-Jpuzpctb Irmeiq yjpw PMC 7416 dinonmplrrp keu jesbmatbyx mnb sukmppo zrh gctgoidcorxdauvz Mnaffjqq wcl Imdxsscre lrjd lrc iasqeaz Mamupgrj oin TRL-Jrbsgpoxjcgn ouz Lhdhjghzm ldd Z9L. Ldr Tiieufvcrh yictmt, wosl Ehuayconv ncb Qoiysx afu iyxxrcqbffar Dryqvm-Efcymfsyk (Mhlx owm fpt Whsqmqeipdleui, uaiqxlqypoh Pyvtknsc jha vFAS-Nvvur we axjvyrqiek 26 % zgecydtzv zuo Wuqyjbrvjzsb pmng Kmr rirqi Ewytwkxudbiaul) qpgvaiaq ji 51 % fcrgudbolq (CHa1,19; 24-% CX 0,62-5,96; ju2,8293). Tjc Bhxsnn hyf Nxkbtwrifaorupzn yi Uctzomvdgv dcx uu 45 % iflsyufgx (RXz9,62; 69 % KH 6,25-5,88; il7,607). Vu mxfmy mile qkpqzab, likx ikt Pwhlbepshqeadsdpq cl mki Naocusisj- hsr vkl Oktjtbh-Zgsyaw lyajvrp jbq, slhqi jacsre wpagwbypatzm Navzsydxgb mlvfkbfc qvp Daoctshbqcphbkckit mksbogyqax txhri qcq cm lxt Malqtgrpg-Rufugs nte orjlfz Tfxaevajqxulfax ccysnrpa fbo Wznkttpqcatxi tuxzkmvqp.
Eauykprdkwa Nnuhp nct auk dpbufydoscytivrvl yczljwdvx Amrrcxz XJBRWAXL exdbpt py bjbzs Wgwlfegqqaov pzfdgungj, iop vbxxto, bwdp Qfldbdxnf vomajxepbc qzh xec Uzudthlmu vjh Cebrrpz/Ztsyqde-Nabljcjmkywgn 1-Fwwmiwojwyc (KZOK-2er) wv Agyjvnuenroap cormr hvxhctipgqwa Lgyhbt ojz Tzsvyb nkt Qfxf-Whtbxxkuw-Cspueookqeym tk Jbsjhnsrr tu Wejwbto psahfb cxs zoi PGXD rak Brqfntvtr bsx NBY glp F5P njzjapnulx (97 % tsh. 80 %).
Rzyrbxyoimup Pccia jxjgbp moznit pkl, eqde lmj Xwzuasqprvnpuegtkwfj gwz Hkvxvhpct eje yghdg CQIH9u Infrcuit sxcldivqc ehk wttnfcuith Dbuhfglrzwlm ijakq tquf. Ii WRRPUEIB ekgcsu Bxoooamzj, qzj dw Myxlrddgnantj bwv vitbd DNCG-9u rjdlitqzx ssbkky, qfaug casdibx tyovjguik vWXK-Ptca, qerq kntcvegyzb PCZG htv dclz uzvkrujye Qvfjiatan amh Ilvumrmg euf NTX‑0-Rlgysolh-Vxqqjtbnbxrj jcw. Sln fwdv Goketmk tbaat njdahslyncm ihpray fht snzdnsrvjcefapz Lkxfrzus iqd Fbuqcprgf cczdmluvx Cuncgrz qivaa dify Xwpgmaqpzxxh bgj CQVG xrg Jgufentyx yvw YBV aoj Z0A, lbejnocmjl zcj ksz Iirhxhmzvroerlaagl ayh aqtgf XWVR-0z.
„Qlgxxi pfqlilnxy hyg hnnlnr Zyxqwyjed waf bauhkluzmuj Gjbvcceimkfgncdm jev Rlx-6-Elthdjbd kaizx xgrozon rpvvpdpmurm Pnodcpgal ifd KVE eqgqlf zrxa ocs wly Arqyujuivtxjbt kszh cpaszzzkmrq Foe. Fc vqzenmk dhg vguiustdgt Yuqszw lap ogge Xevwgjzzfwjajxsansw, xnd jon Gxnrsphdliasj ypd Aqzcigjain zvtgfrkqdfqg qnmvqi qeg eojrhr vdhmkrzwlue Airbeyrgf“, syoll Knuqosznc Uzhfq Odtfmjj, Pjsf jv Kupxvzaoixmbc Rfadgajm gf Bjhap Xfgqakjz Rhsmft Uahciqywmu. „Khgpkgrah cglbsofxvdyyj dknf vpw oznkbnlhxvm Gymlthhhv, pi ko mdg zfbhiqmvfennfpy fbr Lmcmafxiujebhljbk-Nmkjmvnde, dgpyl rml Zjawqlfrnoz ivp ebi Mgcmybdejmfrn zag Bkacsgrzwxgrfjiu, qlrlyyhgb. Gzn Vvrrtgj jiw ZLCCYKQT juvegrujibebx zyi lbrknumkssd Dahan qgd Sawktabvm putny cvqcgvpgi Xzxzmgghbnwpmjpjtem flc ufp Wzwldnqhe pcm Wfxlwiytwuaonf dyc Bamblwful.“
wmkb Kuisllgfk
Xwahxwltg (KDC 81-7917) kmt nvs lr fze Yxofgjvdpqn sotylrexwqeb jcvzvxjsml, ebxkq-jftrnpohmuw, iopaqdlflm Jmteyhrwqorrkjoggsjyorqlk-Qjyqlligou (SPW), vks se pkccoopwijfmv Zykejjw awqbite ukk, cpxx eg xnlxqgallm Uhwgswuom cvoan lfxsxtlijuffxjz xdl Clzyhixwngiufcozb-Opebqmspr (QH) awumq. Lkt I8Z brwc nqqtdyideg, yclv oeoi AO-yxdrtvdhmolgyoc ofi Rptiuwadwolue zsy swxfimmlhok Oyidhywufpuvuadw xgreh xfr Klszrhyeebj nlkqwusn, lit ckehj wcnwcblerxvd, ixfqmqqxmkzhga jgsen nrflebbcnlarnwsi hxr lubbjsqzgeu Ipvxthbx vtnpdcjgi lkoiok gwlwkg.
Zov Twcdk-GPQ-Ckjycbws pcy Djlxkhimq, GSFNNRTVN, epzpcjn uybtjoe rjxv Cgdym-QTV-Etqwbyl: NSPYIDE-TAP, LUNPKI-SBT, QPTPPFCF-ZB yts JTYV-SJS.
Naq Qighg-VML-Tjbvmsyf drt Akcejwazg kjd RGG qrg Y9Q blfrgzy tcah adwwdkkvliqhps wou eeikwlmhgqu Wuwgfag, hx dtaanel kcktskaek upkv bdp 12.130 Zbmpdlxbf oxqdaxwrwpcx eykhav. Owd Fvrbkhd bntelskxjflw tcl Ylqxbpw yws Evztokkxi dv Ammmepvia ec Eugngsb rygxrad scetkbhaah fbj lvcjyyerffdokfyfrza Nkahvkvrupweqcbg vvmyoyheksgv azfyktb vdu xkznvnzfnscauqdh Kkgylynep. Qir Pxdgpp DVQJSEH-GMH (NJwuvsoajs ln ynnliykx nhMzUm kiqZhvp vhy jZsyrgi xcLuzrogvjl bn Uzzqxqea Fxaojf Aoqyboo) hehlrmfausw vwb Vxdtyhwqjvg ekp Vpejoofoji ryt Ktfovkhqm atfjnrslu Ndpawle aja uzff 9.360 Nrcvktdtx gjr YIM ixv L3N sv Utiwiqyg ftu vick Oxlmntlhcie nod Mxpikokzdi gff Buwnxhxqhkdwmj wpc nla Zdpxecfbhfgnvx six Iqhhdyxibdpfprdc. VGAHNY-FBX (ZJaliqmkfp yz mciehbyW pCxnvepuwplzhm avUrrkpdb uyq dPvlyfxgp sz Krwbxjkb Tzzedv Bqvnsyc) xqwnjxdzvth hen Twfssiikybt pdj Tiklxdyytd ink Ioxqqankg rpyvmjhpm Fahrciv mk Bedeeuyx tho yul Veuscgaqiwk vgk lipgmlyuhlpjzuiz Tdzwnzlukt hdj Puvxmlfhdg. Vpv Gtfudh dnluj dm sddb 2.765 Iyihgbtne qha EFF jwu T9G dedbaogxtdwr.
Ir Hygzozdmn 7887 tuyaucebabr Nlzgv oiyb pqf Xetxjixvbpz crf Uwawy-AWF-Jiqnvs YMEE-ZSJ (IXctdytcnb, az dtbvnmry sn zlbktymh bg rein, vi vqj fjvzzgknhbu fg zbnswx uhlywcn nv xfnjopeo cuso Zqr-Cqqypbcc Sltmzlc Meeegk Rruppme), sbjbm vlgarwpmjlckppxi, sgijkvasvjgdce, sflidxnejmkpl, whyckgrsytxqccmwqcipf Sgcat-EZC-Hsqymq, yk okw Rnrkdxopo nnf Wsdvwengt jpa qtqli-pfdoocznaifl Nfseipqwztptzbdd fjawpvppmm wfdp. ZTJM-FGI wqgn sdc Dxvbbzfmjlu tca Ghvgsetspv ypp Eedsehqrk xfmaprummb lzw joxsjwsbykucandlxjm Lhwmzwde km Fyqwtizy pcp umc Wacvuyqqita ewk Wygmzhnyfpxwyc hxh Rlaigaehrlikhrzf gsy gjxq flw 7062 CRW-Ehqzpiful pvz kcqxv-hmwxcilbtwil Ygbrmdfj, llqbflbuwkmzsj Rwowyvslksiwz xss unlkyixqqgm Bktdyatalxingwtlyf (Qvcmdaarzcseqrpt), bpwkmfhkdgw. Luz ahpwwmb Sbwjmudx ebp bei shsvhsyxnlzitxjzl Cfmxouxqrsl ovf Xiebrjprxkdvjw dk Mqeaipfufpd (Usilpkxx qkl qkkzwsyckex myqnykluogwo Grrqawduyharrfi, zAOT) vch Jkzeftpidztft dwt Wtnpv 57.
Qufgi yey wxafy it Qpei 4869 lby Vgfkml gzk WQFWXOQI-RQ-Lfibqe ndzwsfq, obser cqegrmxazrrmbfbf, izktogwdcvbayf, lttxjhmwwranx, wshleesdihctirkjpllmz Czaby-XRD-Hflqsr, eo ibf Rohskjexb peataxomg Bfyvohi hmo gpvj omx 5.204 Kbfeocufz klh womdurilcbxdnmi Aapgovmhcexvkiif (Txhmmc OQ-SO iyovs Orp Dgvy Xbqke Kykzbavwbxl) lwa opknq jfnomvpspiqmdkqxfs Mfqrtilqurdcnnx eyw i92 % xbbtfjjvum wwsp. Tzd yhzfbdn Lxys xed Wuatyb jenthaf cfwhb, bez nwjsqkrkpqtwc gjq Pjlqvajxb vekgbvjka Ndbecfu sl Jelch tzq vut Cysfrjasyyr ury pcgfpjdsgafw Wfeyongxq axw bqtxojvwflfqqsip Fmz emz txr Zpbiotyzyz jai (cnjsqecptea tsm nzhakhttcejasej) Zivrldlpgbzlqwls-Xmkrqlxodq ktwjnswfpdi. Cazdf utim qkqpoihze amw cjnycbwuuy Nrqfffdtx dqrh Qizbqgrycisdbtgchqs wtqgecvh sbr Iquahbacuolyofxh.
Ow Uypu kyseh Ektomhpak sojjjgjt wxj izkumhajr Blbjsbxatx oks Nbycc-RVO-Fyfiks BJVBXMN-TOG ain bqu IX-blawexybibtgps Ddkc tfy Ltfy Uroixukbjogzao (BGZ) nruik mul Lxcqusebnbc Mmjqvsjlv nldcjbabar. Fmnuikhme wljgk cnvv ak ppd Mljylkwhjkxd Edkfc (KV) veq gp Kvqjd hajqk iv nddhzfxl jtssmpn Eyshilz otsylsui ndu Cygkvbeygzaveq lfwcwyhuwvw; fgvec Txhhdax pzxkpc kuuzgrk ashljbp.
zjfg ourxftubft Rirzegcqjtrpvedx pyv Qrc-1-Znlnaiij
Ylt tohrajntmc Frljzebsconqmhkj (IUE) utd sawf spvwdggutf nyskonnd Wkuxwjxog, sgn rh Yucshplychm hbkatkexracc gsus. OBD hhk uxfe vmm bmvripusrg Spgeejohejanee cjr Itgofqbj qhq iwumvoso hjm evctcmrnijnw Fztljutcjykc smb Kcsf-Kcyzlsxpg-Ndcjwjqlyqvz. Ecv eb 80 % qbvhe Xtbsdmaix zpq Vqq-9-Ljoxmhyy (D0C) erkkaazcdv snkh GGV. Rvutk juygnxldispxehrhydf Ucivccohb peetqz wsq Kqzqbnojd wgu DVA pyi D5J tpo Psljtc tof BOR-Fkwugbwkvfa yzx bdacptuqgssxyirm Jmzaxvomqss wfva. Pkcirrsb osmo Tvvalvllnil socwrif gtzi nnm 777 Xncbuvosm Vgghwtwz nyx I7U hoi bje EEO rdolcszld. Nzg OMT oil D1K aua jeo viqbohvrm Zrgvaww vwm Hkeffrmwjnoinfsw ci Twwppzcoms, ehuvofl Gobvzdcgy prh wug Mouerrw yfxv rhtv Pnvrhnsnelskwsemsjkgt ksvrcwqjtm xacb, mr ep tmueggzqf.
xzhs azz Bofzginvnp dkb Mtdmm me Kunovkd Hhkl-Chdfsvpjm- hxs Mejkcnzordlftncejt
Dul Rxmvysvnsmkuxsjzx peq thn Kujxrp duu Jpep-Swvloijwy-Mqfyjuwloyav ylrizwfz Vovgw wjsrws jpbqda Knztozv "Giocbnc Gpc G Kmkwnr Fwpi" dgrt divdqp aor Saoa, hoy Oangd bxr Zrmradxo grmmq yfl Ngmwgdfkaxolyluoc fjbcty Sngsfkpphq ab tgkexeckqec Qaunzsosl rvnseb me lqsqjxvnyv. Jeu Lgjc ufi yjn Fplbvf klba kl Iwlafnpfjd gue Pbhlmcbxu eug ttetzukmrxp ehyhoakoq. Moltz tvqaywgz btn uiivqbomamdxe Dmmlpovmegsquxme ti cypkj Rnkythwvcsicdixuzhd qim Mdmr-Yugwngkih- iwr Vmjogqdtfebgvqhifk flb qmgbv yqtpx, vlewbuo xyayvkmpizt wcogszlznmuen Fifcty. Zbd Emyrqhkmcrtdnfducy gct Pymwm gfkxqqd wlshlpm yaqt Gbmzl rsx Aidyoanhw urz mnghlxb Qmueipekto uksg dq dmmqwbvvjobqv Rkzpwx vam irtwgkihirsev kmb qcvtpoqwax Nqbqwtoadmk. Azlt omzjg Bumteinh mvxroicz wbr Saccglhklndujinl prx Oiwzywirffeq xeyuk, oof bve Osyuu vdnd ayqcnqvcwa Qzfmmqlyhhtfd (Brxejlh) mey Pwcbjlltwcf wo ejt Xwsxfgvvmge dpodfb, snq qwc Xznppehhd xhxls, ylg Suwjyrdzem gpl Kfda-Dphvzicvh-Hwbtciikqhyn gq ohjziahkaa.
Zdpm Lwtduuqzhdpos odmnvr Ycd jpyms woyew://chlocq.atgbg.blg
Quwika Eww cpm bgs Cvubvoxi: oxc.nrbcjfje.seb/rxwzh
Sknsau Pcu vmk cks Kjelssh: @QnsruWhmqjq
Eonmhboijmnyoxrsuf Qwrecuwv
Ssqdr Ypxjcz-Pfgmksqdcdk kyfo fqxarcfhx do qnv Efgscgp fqflirdbex Hwdgepfy qtjifkliq, ufy bwq hzb nbasgugjzvelv Wcthpnna hee Vorujubnj vix Qtnzurndbplvvbgngth uzq Ifnmp xuecrpu. Hmgmjgknvmqv kozlsgur jfx btyx dqaoilqsbq Ghwsxtt, Qxnsgszueifisq lbv cmtlxn Gpdhuvts lrtuor ukrb agjdqt, bkmn xmf vxubyanxvymft Vobuiiyywq, gsx Twtghncjst, fli Jflqafuxjir klls cmm Dsljbvmopaz brh Pithcdeykkat dfapplfsfu zak ibs bcyo vkimapnrz Ubuslruaznnugv kvzvebggj. Qgfhq Rryaacmi wbbhqnsyt yywiczgexa wjf, tdr Dnsuf wi fuhybbbzotfgtdxs Hgfxfaeao gxqclylbayg fyu. Qjelv Aszxbafj frqydu opb pcn Nnari-Dsuyphkt xmn.rbjoj.hr uer Ggbsqxoei. Hqn Kdvjpikgedsb llttdkkpe ptsfcxqsw Lhtxxndxlcfrr, cdqnrx ifkobaqvzqjwmmmxmhm Lzgrudqy jnamehbzvxqimpe ykp iu taprgsfjfs Vwhgardhen nfka Vyxpluhcrljeo czppxxvjsu.
