Die MorphoSys AG (Frankfurt: MOR; Prime Standard Segment, TecDAX, OTC: MPSYY) und Emergent BioSolutions Inc. (NYSE: EBS) gaben heute eine Vereinbarung zur gemeinsamen Entwicklung und Vermarktung des Wirkstoffs ES414 bekannt. Bei dem Wirkstoff, der in MOR209/ES414 umbenannt werden wird, handelt es sich um einen bi-spezifischen anti-PSMA/anti-CD3-Antikörper gegen Prostatakrebs, der von Emergent mit Hilfe ihrer firmeneigenen ADAPTIRTM-Plattform (modulare Protein-Technologie) entwickelt wurde. Wie präklinische in vitro- und in vivo-Studien gezeigt haben, lenkt MOR209/ES414 zytotoxische T-Zellen gegen Prostatakrebszellen, die das Prostata-spezifische Membran Antigen (PSMA) exprimieren. PSMA ist ein Antigen, das häufig auf diesen Krebszellen gefunden wird.
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