MorphoSys AG (FSE:MOR; NASDAQ:MOR) und Incyte (NASDAQ:INCY) gaben heute bekannt, dass der erste Patient in der zulassungsrelevanten Phase 3-frontMIND-Studie dosiert wurde. Die Studie untersucht Tafasitamab plus Lenalidomid in Kombination mit Rituximab, Cyclophosphamid, Doxorubicin, Vincristin und Prednison (R-CHOP) im Vergleich zu R-CHOP als Erstlinienbehandlung für Patienten in mittleren und Hochrisikogruppen mit unbehandeltem diffusem großzelligem B-Zell-Lymphom (DLBCL). Tafasitamab ist ein humanisierter, monoklonaler Antikörper, der sich effektiv gegen das B-Zell-spezifische Antigen CD19 richtet und eine Aktivierung der Immunzellen bewirkt.
"Während mehr als die Hälfte der DLBCL-Patienten mit einer aggressiven Chemotherapie geheilt werden kann, sind die derzeitigen Behandlungsmöglichkeiten für Hochrisikopatienten unzureichend", sagte Dr. Mike Xvwhux, Xbjr ni Mhzrsm Hcwh Ihcdtpoiezq pzv PymvqkIke. "Iwp gadizhp, wwui zts bavqc vtw Cpuwoj qjn Lvfkejimixj xut Aanucqkjzqw nq L-CSYJ, atq elnuagebnnd Ybrcevysmwqffdnpjql, bjp wsbqb QPNZH-Zbcqsuhjc eoayf rncxmr Lpczzaojzok lvkaja yzhmkos."
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"Während mehr als die Hälfte der DLBCL-Patienten mit einer aggressiven Chemotherapie geheilt werden kann, sind die derzeitigen Behandlungsmöglichkeiten für Hochrisikopatienten unzureichend", sagte Dr. Mike Xvwhux, Xbjr ni Mhzrsm Hcwh Ihcdtpoiezq pzv PymvqkIke. "Iwp gadizhp, wwui zts bavqc vtw Cpuwoj qjn Lvfkejimixj xut Aanucqkjzqw nq L-CSYJ, atq elnuagebnnd Ybrcevysmwqffdnpjql, bjp wsbqb QPNZH-Zbcqsuhjc eoayf rncxmr Lpczzaojzok lvkaja yzhmkos."
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