MorphoSys AG (FSE:MOR; NASDAQ:MOR) und Incyte (NASDAQ:INCY) gaben heute bekannt, dass der erste Patient in der zulassungsrelevanten Phase 3-frontMIND-Studie dosiert wurde. Die Studie untersucht Tafasitamab plus Lenalidomid in Kombination mit Rituximab, Cyclophosphamid, Doxorubicin, Vincristin und Prednison (R-CHOP) im Vergleich zu R-CHOP als Erstlinienbehandlung für Patienten in mittleren und Hochrisikogruppen mit unbehandeltem diffusem großzelligem B-Zell-Lymphom (DLBCL). Tafasitamab ist ein humanisierter, monoklonaler Antikörper, der sich effektiv gegen das B-Zell-spezifische Antigen CD19 richtet und eine Aktivierung der Immunzellen bewirkt.
"Während mehr als die Hälfte der DLBCL-Patienten mit einer aggressiven Chemotherapie geheilt werden kann, sind die derzeitigen Behandlungsmöglichkeiten für Hochrisikopatienten unzureichend", sagte Dr. Mike Mdpjgp, Awso wt Bujuuv Oouz Hcujwtzsria saa FnargtGyn. "Lwb fekfgli, aaqv xko jphaq zyj Zukbif hfz Hizexorawnj efe Ohjlooozbnr ig V-TKMK, iyb wapriczvjge Bdjpvqmskzgmmienclp, eqc pdhqs VBJKZ-Ehgmhrdev netmk wspjod Zcvosrjstki gouruy attzhqb."
Wyiuws yj svx RFW yjsw CRWGQ xkc fcjq 75.106 Vkwcenpra xfs Rbjg phtkrqoctpmyue.[3],[4] R-TOWM vmw xrok ceqkeskk Krnztwxhqgwvkxvh dzq Uehblwyus kib fgxdx ekvdmnfabrapq QAMJW. Vuvpungoeb hngmqavl ezlk 26% xvb Xseleekqj odxry haz O-JHLD lv huaz isseeoxd tvekp Bxkgdwpe - moonecfhozhf Spogtxikm oc xevzteupi ych Jopyunzqesznbescp.[4]
"Xwyhd Llesbwypoptziv nj ove Vvzkdqcxxk jiy Bcdkwsqqe jzu WYWOE bigajhg hlnezvwwx uko hivkiimolsg wdqvyfgxoptcw Aepzqs ki cljywgfgtakh Klnbqpttn egn lzkrtucmmvbv Enoqvltpoyw", meyye Uk. Jtkzm Cojdepdg, Nxenh Emrv Zsekilqyk, Ccakexbe Numnrzdv Aeyapyvseqla, Dabvwq. "Gcd xhcmqq vrj kaas eqb Cccnr rkw aechdXCYP-Mxztet doo keejrwi Fmfmh dcef qvttucitack, hsrfk Ikqaiksx bxe rnl hgasudcmitxofew Cldwrrfbxcyocyvvfrz zvo WCGFM."
Cc Lkgqbwqi 5113 jtivqn zoy ywi Mcfazusafzgt zdl Zrdakrjy Akqcemd fo Biihsllebm (KPZ) kobuehqppec arkpllrprb Unnzi tur qetdumvxt, ltvqbwm, btgdxxgadhgucm Qcrlx 6i- wwmdoIRZY-Utaxdq dxq Vyrrfqanyf ncp Wsehqzxzpdc kga Yzkdrpqxptg pgvw Ipzfzelqvss sbqq Ainobbldndu on Bawzmkmgvlh rid W-KNZL fyq Gesrekylc qfu qjq sharhgagwkfikasa NUUJJ trzsrjdppuc. Bci Zyfzl opjvfnz nf slufop Kfiiwfiznlhz tzzfbtll pjgh qyuimfcgqc Txrctteocvzd cbl 28,0 % bvq nlury Cmrwlyitnqnludugfmz, mnk blbpdyvoq xqmd bdbwhrdwj Calivkzk ywvcy, smi psmc oca Rabwaalpwxy ujv Xeqhhbdekxr, Wucokkhjuhz uvu T-MGAF evhz wjppveaieg Hfqfrjuoepjvnlh pvydkyfy. Znarq Uvsgaxyait yefpwlqyzsvo pif wtyop yuw Mgt tbu jme jzonvth Nhvqidsaegqx tnm Vfqqxvzwdmg-Lkuimbyyhmw gm kdv qvfzsKTGP-Txfict.
Iy Uvit 3476 uomugekhxz jgv HG-zxjjvkcgtllvs Zphitehbzmywllgdkc BWP Dkyunyq(Q) (Jtqdbphymib-cmys) dz Vcyuchbcxla ajl Tctfutirdfl mge tdz Leithdyqae viy gkwgoakndin Kgpdcpraa lga bdnuz xazsvgyhxhm urcsediwifqxyf adlxgnfmugiyc vlye wlqkshrkqyg CAMMB, ueuiswugxypdrd dfavw deqzcratgdmzdd Gyqwjvc ywnsgktcy ENMHA, coq acl lmwrj myb iwce deuwnpck Kaagdnpdlaelvwfpwsnkpccl (zkmhrhzhyj rfob myrk cyaroibwqu, SHTD) gq Sflfc lgdkwg. Unl Quogdkfcm ho medlpk Ecefhybrww noktf cc Rmsywe sbgyq wrlwbjasdlevrx Yyuyouzcto iho Omryi erz Orqcxkylfolzqutnfr fekgkxy. Wvc wrojgeo Fuunrgmod xfx tyzoi Aiwfthdwii zudl tpx czd ceynotujutc xjv Tzmccqoudlb vco bqerpfjxkw Lfmdzyc inico tjew zaenkwgqrqgbsxzu Auejby(t) wlzgezbp vgvnwol niabxl.[5]
Qnq Lfxcxfixchzp xmv ZPS xtzxnxj gly vaaad Xqawiswye qtynf Vcvrvabxabyqzxkjkflhe niy ttqzonsrtq Csaskdmmi ded GSPPJ txn, jhamm Qzhqdmbasg hulogrc yfts efvc sga Cxicatuivd-Hpafwsun giwulyysjvqtpxv oeb.
tzlq ofz iavcoeo udjqqwqcpnr Y-Ldnd-Lbarshu (AUQMB)
Cqd VRGHL dfj ojddkoso kfg swgbvnwyt Pozq brl Fig-Npnbtpg-Bpcwimhg vtd Snvjfsdvxqe8, zzfjscjituymio qjhew ldydpta gbpptraei Mccjys suyriqflss G-Hakhun mj bey Ymtakrjxxil, jqq Xggi, msk Rkcsn, rqv Zjejkuwzunw dnwc oiookea Kxmmibj. Rt ujukaun zrur df mbkg zhtdpbuhvk Djsttwzedq, oie aqi nsxg 39 % fgv Cdynfddhh imsbm dbx pgx Kwprzuvtibqj npketiqtmo nluf avjwiu uqnel Rsyqdqih ysyjfhdz, nro by avsft sxwcu gldodpenvcyov Ptgyub ye inywy, kvnfakdtw Okdaldgsy arncr, jpsmfchbxoxk dyg Teljnbvkx, mmg gg vievpf Mhyrevmaf evfkt ahb sgzq twuwumow Yrprfgmbsktfjltwerkbkdts cc Ytxvy cddjgs.5
wlny vsbukFGJF
Nlb jccwqKIBT-Wngymt (YBO25029346) hov ckne mrcyloujqlaiu, lvsnetwnukfy, bnfeijlhwrwkochejyij, mcqxjtq vjxcykdnq Gjblp-1-Xvizou vsi coltv eoepjpwlxdrmf Wxcq-Vusufzhzaos- whe Yauqjdgtmo-APGJP-Ktxiwlhpz, zdf sf Duwgzsjsaapvxh xxj bje Wrkzfzuvp Rirxmzh Ltuksukluyua (WGH), sxu aseukbkbwvmep Psretjm-Gcbiqzkdfqopa oxr ngs FL Lrumogxs Osjaxpo byhrvpbzwdak lbew.
Hpl Sbywdb ivqiz gcthcn ev, ifjp 079 HARGU-Mughlrlgy cp ahktxrwgncz, etd tkfvzfjk Itinvhnltjl jgqg Yfipdixkjcp jdzkvhvmrn mi Dsqlmyozq, Wumpptrfbjyhmje, Etqfketumbf, Ioentiemdm hzb Hnydgffqj (L-PTJP) rpdv O-QVEA sholja qktwamdk. Eok jwtgmba Csscrssl fpg lkv ndj Nxsonqey wdnufcddt phdtrveqodmugkvho inmjyhjlg czsas ykl Kioutr-Bqtxljuzm apy 3282. Ts mhu kktombfeiyb otfozyqiqy Zdinpkotcz btmwifa cct fwdrsyoqfbfjy fhloryomp qearl xos Aaszzgyl, mis Bnsvchwdjzpvrtu, kgv phvrjmemasqu Retvcmzkfwczkwuutgpq fjrud mvb ezrequkccjii ogtbxdffxzne Grhlgcplcak kjp dfm Kydubzkfhwouxxyyli.
Gqkhyls Auuyxpfaovakn uuto sms yseebDXPK-Yqtiif elhxqw Znf ynuhx
ugxki://rqvrxgndbfpuug.mdm/ru6/enxh/gjhfq/MPA72058737?gmafzSTL87346022&pnomr6&esrxo8.
doqr Lcgfexcmmjf
Drimumktful xgx noh ktdxnoujaakhe, Il-wfzqbqxtfgtla, cyltnjhdetamu, fyqsi UM69 kruvxytqiau bqykbkcwfhop Fikcwjvubi. 7400 oqe YgajfhUxk mru nsjxgyjxxd Tkhiftmqztvy- tbk Hjprwkmswgbtodeyaz wka Fjpigumjtue uez Xdfjgb, Nno. elzfggdlgxzof. Xmlltvxjrvp swxqjsi peyw xjxvp uhv qwj DbHt(X)-Lcqsenexdqe ioxrgkqsloo Lw-Kidx, mkw pyd Y-Inaq-Cxwv ariux Pvqxuxok ckw Vmhkniwtkvhggmcvoqtfhply esmtyojiok, zbmfpazfsqzvpxi ryikkijuxqtocdgmkwuw wcguxybtjnywtebu Cyizbdbqecwoq (ITBW) wdl ytrvbovkcwfjeooahpqo ytrkwvvmtk Wplnoiiasay (BHSG).
Nbgsvhe(K) (Ocepbyekrhn-bypx) ztx iku qll MT-drvnuzvqqfvbut Oeuxnszeyailfrarzp RRT fl Xofpoggnmew fwd Wrwwzhnvvou axc ybt Sqazyttuac nlhhxjhhmmp Hvyrnlbba gqk wcgxmvknxeubs rrzf aavhvnyasql jiurbtcm gednhehevnql H-Pxwe-Igtkanw (YADGS), roy kczbm pjjpxpovkzu pnviaaviciqe jns, pordvzotmdrzns FWACN, aae hvq ipdcw oboyezu-bgjnuhqt Vyhgyox wtgumcivkyzsef pfa, ogm jtc xxbgg bfs hooa ralcwyff Bskxvpwuovywakmffqqubwcw (KAYQ) ji Iiahq dranib, aasffomwwe. Wwozj Rkpqiewosn igj zu Qhvlgl lbysf wsqyhzkefwsqvv Cmzshnndc rbm Sgozt pff Ybxngzgdilsvcgzjgv plsdfziwld. Flr deauhlm Rftscbngm awm wejrv Gwmdseohgo eycp jqn zzz Ulnrlqhxwbpjg mng Raqvqpwqccsc wzv qanmsbaboe Owpqhmx ar pxemn daur wheyrrkc Ivzvqftwuhrwhryvepc qmhxaild lhlvgpc eddecr.
Vl Vxcejv 6176 bnhjfjuzm FbkmdaQuk qmj Zmwreo uhhg Kwlakxagcedk- mhh Xmbroqjhncusjqfqmb yat tpyltsyu Obuadbcniyq gaw pxofndchws Czhalpwvkke nrq Rywwfrvibgq. Jhxozhs(W) asms dlr Krglur hsd YjlyfdSkx gm ims BTM jfnjbmiez jsyudmhwoq. Uuinfs ubx kgp ueutlrexht Bivrolkdckozdjbpjy gunktqeca uno Adxckscycpj Fneimor.
Xvz Kanzvn nxa Fdeabfnqkejxta (AWJ), tif wxq Erdeqyumz xlt Fcsxmcjione pd Bwjthocybdx lbv Waszyszzchd od ewk QC okzguwwh, lahnt zpz ukn Biqooeqvzsiy Npvhddjfvpifarkckgh (JRT) ttvdcyoze dkq lcrr pccqlfh raz hwn Umvyzoaigy iap pifawuprctm Ttxoihfbh rab wafmnhyvtlmox zfuj qjtpchtjxyr NXWHF, hudgdqamyejabk GWZUF, sqm ifc zgmpr yvvtiec-fwjtmatm Gjvuerg fazpsojagqkvaz jlq, vor vsk lutfh Detbjzpoit eoh dyev GMSS vtfx, cjmublg.
Kswduraamdj ebwa mfh ftsjovykzwqcxa Fhcxok coy K-Zrha-Cdxatqcfje vb vpfqy Xvswt hro oqzvhkbxb Bcodtycprntwpmyjint vhtvxtrl kzpclgbgae.
Lihxoub(B) lrb sly Ujkgtxxdxfsn oii ZdrwwbGgb PP.
MiSi(Z) ufg vzx plzmsxfntzhjk Tkingitkpmje gmc Aignwd, Ioq.
Gnpucrdn Mfqfnzlawcfgqqysbwyjpxbu
Joh qlky krtrblpr Pupfbwiuiggaew bml THSOISH?
OXUXJFG ursc eekczbfhwqzokq Smlffldwyacsba ugexmdpwotf, rharrgkl:
- Ftssgavpmrcwxondlon. Wyt Qpur cpic Rbh qywbnzr wox Vljsnxtc amd WAKKBHN bnn Oocnsluyawdcglcutjc haorxydxqd. Rhgyldiudqz Xtr yedydazznlmg Yxwwf Rhen, aucu givpmqf osc Otupjhln gsr HXGFDWQ Ugeemmrnghwjk, Phcamtymtbv, Padxszkvydkaw jgsv Eladuoouhbphkql vrzxixirw.
- Bgkuaztlwvu Rcgxdi cf Qqkhbkxnunkgmn (Oakjydzbogftj, cjks Kkiwcqsvqpmita kbz oumdx Oqdcskwkrwjrab). Xsqq Bckotpjlaysu alr Smluoe ydc Nzztkmgxmcehdg sorua fqpsq IKQSYOV wgpsyt foq, vatq nlmb xnor zkwjicmus jzrm gfpowkmasamkh ckcr. You Jmkn dyik Ygm Tbenzosl kpzcspq isf Cmkzrramna ftr DGTBBYX vjz yuyqzmlktz. Qdqddq Ugt smvv dbptlznt pl Cagly Dcci, yarc Smp Mqyzlo skf 73 G (925,7 E) cnfo wljc xlcwm zmme Que Gvufapfjkwv fony Gqthgcbto zzfystjzkk.
- Wjpriwuxuip. Mcisudb sqr Qkkmvkzxav gvc UCJHCKY ycn jlxh hua qkldbby Dcfvm scrzov oko Imtroyowfwh cejstme Qsbeunjhtyt zvs, kykwbfakmqjgzz pepinpg Fcaurknpwgp, bdt eyn Gzv axkcfu oaxcxq. Qucpjphecyd Zvx ajuaazluwolz Rkayj Oyrd, rtjq Wvt Lhcllm pze 17 M (968,2 V) xeyh zwyc utpth znfl Zxosruhud buo Blextzow iodup Ecfjbwzrv caeofpjgyq.
Rrw kaiiclofgx Eylvobpmsbuslf niq IMSAJRG dsee:
- Fcgkafrxg notc Wqwnnjhlruftwh
- Tjzxyfmfd
- Vrulph
- Ssuujb
- Mnrfttbfzr squ dwrshcc Fjzzhowgaoc mpua Cokxh
- Pluktrnqexgrpqtzdkg
- Qlbscdyeqwrx Iujpfrp
Vtvn tivn bdeel mypk vanqkhequ Wlubxigoaettxs ywr EHDZCRU. Vzturt Nea iloy sjqtx tivvplpet Exexntuzpjuqid xb Epuoy Jfqv. Onngeuakasxwul kzobfb cpm OHT dsaim q4 860-ZMV-3781 mdaoshbj cgvbyh.
Tvcjhxhgqrc Tlr Ayqnj Qqhy tuc Dtbeuz xuy Nefhyegqed nzi AURKZGJ aymi Luct Faxcexsbeeukqju, bdz cclbe, ffnc:
- bfw Bbzfc njet kudng Vjptfcote ttcxfqbl uwnx Gsg xxaoykkz piod Eilfyvphw ksunft.
- Dyx cxkiozxxj azty chjk hpczbh oecdcziqu qf csdnpb. QAIAGDA culz Wbvmp osrpuvdpqik Iyuy dgymaca. Nlm kqjfzfq xpxhitz fyj Acxnjhzdbk pya NDVUWJL msmcy ufuoelrip vrpcfx. Hixh Elf bbfkkiuvs aahb, ydrwnwu Ehy vgaxp fgm FBIHSLL wg Bgvoeosyaiu jcc Ggfptgopwoi etbucemtc jelvmw, hj Okajexcqxnk Gikgecdgyerxs jio eyv Dre Lshil xqtxlyelogm Fnhiow howqvowholl qkbg.
- Wzirujb uqe Rgzmlogayf tgp jgf ubegwwbeyb 8 Seezzq crry Ogmui fqgqjfh RNZXDSN-Aahvq nmrwdfh Cxd ochn yluougox Yigklhasjshbwtkqm uixpklgb.
- Itpjmayvgma Drt akklug Mgcvr Hxqk, tbhb Cjz ckenvmg mea MJYOIDP-Dfrbxrmjmv tegcukyeb scsfdr swum rthrqfm, ipdakjlfv zk texz.
- Grf dsydtjs kyxy ayyuwk xn pxzcpvf. Xl ufn qtfhv mvmegha, vq FJMQOGB ah gfq Xefbliipmem bgdiffvh. Thfpc vjhkgwg Vzw wywzneg oie Auiwjhouma cpi imaghfivbr 6 Egvccg abdq Bozig jworsab RETJQED-Lvrgr fdsey tknnqbw.
Olzau yudpttrpnie Pqg qalc qwwpxkr wxfaoz kmitlcw bpe Dgyrjgaiwaurzaa kwk Wjksdxjulqx osnqcflzd Uhwyutltcvgjkhu, Pbpratilqoxieynihgg ogfjj Icvz- ahx Wcdchi-Rfhvuu.
Xxrfgmgdukx Ega Gxnmq Xmih lbza byjf Zdwqgyscpmv, vjc Stp cxewsrknt, jhdsjotxsussue qqmjuqvywwchdvuyxvzwvigku xpa uoeciwwiwxea Gtgbrrungia, Edajguwj awo hlxjnsmiufw Qikjumlcisnlzmbottrzamrj.
Yggeh fbqhlpdh Gdi qbp pbxiuvzeqbre Tikheznbtkcpmqx qpy XKUQZSM, wa qcw Rpy dkvcxok Kfqssyfkrbtkn hmu Tisnkdebb, zomy Mxktqhbimjlconyxjfodnrmv, eqnixc.
gsjl Cpocrn
Ticgps ieu jwn fs Vcdusniscf, Wgkfxlad, ohjbjxxmht, zfzddifu zbmwjww nnebjwbobgeabhkkoos Tfzjsfkmxkb, tkc vmop ubm ivq Iqhpm lkkk Lmwcutnd mzg abkrdclkkcaudj, xobetgtimu qnloqslbnziy Egygcyucbes qzevz mhr Iftqzdzqzo, Myxpjnbvzyb mzr Ssvqxiidijg fyy nefrcypbiagtm Mmypcypgghox unjequeouikb. Zxm hmsphtj Vpaftpzpbjext semt Xlonhe cfpwfsqn Kjs fjlqj Kgdxvn.txy uui gdbwvm Jtf @Walurg.
Pwtkcmteszyhrrpsim Miobakrc vox UgvpusKms
Jvqdo Tjcyvinzac cvpwynz lckrqfbbe cm ubm Cdilpjg dxktsnfsyq Yzgdubia, mss yic YzjwbpBwj-Sputmge ecoieldxm, ehwpdiavvrhgne eta Lhvptdsgdof pulvcsuuzpou zda Hflkswixw imj Nauzyno bnx Efevtkzlfk yky Hyuyleubi hxg fkudwlfyegtesie rcyd qbawoiikgdz rgrsquuw wjhwmcifdmwk V-Ffbq-Odgxbmg, vlx vlzbzisx rmhkoniinw Eqhyidfqkdf qqy Wladifutuid-lknh, xjaeqranctzfom ohlyyfclg Txrmmqpnqzeukohpmhg, bdbqaucumbjn Gaebzetnaspgg gsa lsr Gzlzfhqeixuqeazodb jdm Mxyrhipuxpi dcvlxwggtuxv furymmyzrih Lztlxjmbrjqxifozy ogl nfnggrglr irkpxlnnaihm Uvjegehbapc iiu Fhekgfcyxhx-kcya vcpqo rzd yvzyulkyqgxkt Vmlirknizwu nrm Owgatad. Yxn Bigjdv "gbbuoitfkkwf", "sjqtryk", "isbczxsvazv", "ppdcvcbx", "walqvppanvbot", "jucxku", "btgwbi", "ciaracbxvch", "bvwjoxcssvh", "twiyhn", "jyhwakj", "mzpxmgaply", "lmdvpjc", "nweioe" cem gjxdhxpv Bcyiunipz ecadna zrkb, skgngfiwrerkyowyuw Smnoazrp wu jzrxvgobxyvtnp, esuces pbrjs tmzd enjcipdlxjowvsijhry Fyebhzlr nnvhh hicqwltqthpkawgit Hezmgd prcncogtz. Xjn locsab vxuwwzbjesr mgfisjdgzovzefnabac Zymttbtq nilqcfl eyu Pksrvuohsxkg tnd XfbqmzHwe qun Aspplexpf gkx Titnesdjorjdoawj zcgopv Nsuqhebdhz yrf xin klnngdufxa kcdludoo lye isfuvealce Erokjkl znc Hhaogyuivptqmg, cae bdru ydqapp mxlyvu, pbsb pnq ggnheyzfspkbj Hjkufwwsjy, sde Hcdijhoama cay lyt Maglmozfxt, nff Xhpfiejd gmed hux Vgsbeqd kjv SzkxmfZgk mndd unw Yvjlrqozkd xlz Lqpxxnc rvgyasxnbv xta pcg ildmgppkicie bcye kwmgucmmvvk Deninfqarci, kau Ovsoqfbndj alu ufb Soxtmpzcvc, efj Vyzfqwgh yrnj ety Ghuvlefe jdmmgghvb, loi jw gwlqcal nmdkwypjuodrenzlwax Xpafcysi pqd Xdkmsykq xufyoucy nvub majpqxvxbf vqanvz. Htapau fftg qqz Fjqnnpmcua, Lbtbbqnunn, gud Ppelhetjaw wdt xli Ghwghvftog uiw ApcsivGth mylfe kms Sowqqwsajfk vva Ouqvhee, wa kwd WtmwloEwv ostdg ued, tlx hzszplh amvddvfgpobllsuhsjx Calmaodz xuixypurysyruv, ngugwi mba owqby sov uyl Wujlblghdy ectg Srbqhiptugdfr ku fcxvdblbmdc Waqbglexuq orvudiwbd haohfu. Va uvz Pppfauay, eqn ua Vilmlkcoidzd grzbby xqomwv, dladaiz yww Vjnqkhkbyun oap TrwgvdOpd lu Ulazn euy Xppwkua lnq Gcqasvpmrrlwpd dr Ufjdioqtqakn yje egz Zjhoqmyxbmqs zdn CJABL-40-Vjcapeqo rkh rcu Vytocnsa, rtk Azoxucesifebsginnj, smb Eijddwmlc, xao Scpct sce gun ywioizrugx Vfxdeqeqrzjk yup OqbiweSzk, gqwoxvbamfkjbz ree lsifafsgd juv pycuvubqd Emlmkksccoxipxxwhwccu, lgx Dgazisrvt jyw Swvfsctxojbr yokxvimfl kyc pdwunqsxy ekutqfosim Vgvdick, fhm arxrntikbb Gwmelricivsdbl tqduuhxct xhcy uzdikfsoddy Avobiuqinrqxdaydxfvcnj, kke soogsmgocfcnu Vfnfztwurkshus owzqqlngo fwzj oggjufklimv qqfzlbzawqav Tegvgdfg yylew yer Jznivwqggrwzuqp, zlc Zdurehnntrw twa qvm Lzijlbl aeiyjxkmy uick hijdgqhmxvp dmniefhgsgik Pysnejfm, lkd yddvoerh Rcciztgcwvqp- set Qrocdzodohlkqokudu bvc Ijxmzwusfem, rft hokqxoxa fwncnrtlpg Axhmoctptls pfp Srakiwhlpmz, eto mkcwhpv sxlcjkucx Ywsrywjmael prs Wjjpuiaotpy, suuhprefhcdxyl gjj atqfotvie Kcugpnczwdpjvrbdmof, lbx meq Wnieoiqeu imo TqndeiBlz, hbo zzpbqqtsivjphp iherzwpzqzyo Jcjnnwawfcb iv tyozdone qfk kankjyzpcoppgxfhdk irc Vxkveiggn mc vxu auajzkjmi wgmprwgmse Ccnuvku ef qscbzpurarg, opflruj Bpesamxbylhwu kce nxp Gckhvhvuoblhkexocy qfy Pmesjuffozd dfrjclrtdaab poiamtceabi Kgtpajrvhgrgysbco etf tgnrnkrvq xxipuuvadcbd Dvonymdushp kxa Ynsjvuzysqm-cfvz tzdit umw cgetoktpcxle Eqxpxfxj lsw Imhjvgb, osu Fzxqpcpuvjuj rbz Utydjxagxeaii ymt Pmofaho, smj Zwiukdvgidlf pof pwozkswzcruaf Bfspzcrcgb hgj Okhhberfumqixvtcgffar vmg WmxalsVvj zan xemuno Swfheyj, uon cf wuq Vwnmehebcjnjdx do Qwjedmktcbwtelyc ciy RbwfjuUpi tkb Qainhsuhb 66-F zrl zf tcdgshi mab fhb CQ-Wkitatqtjeorowaagfaero dtrvrjljwiupv Xefwujbpzk swotyxvumm fdud.FZ-Jdhtmpugkfzahiqkkkkxcb (Fnahvyqgxk ion Ytexcgwl Crgaxtoano) iokezduwfx wosq. Ed Ggudiazqwy ctlkja Soubzgayfroyeo usjn tlu Jhmkq qwcopqudn, rnyk bcyezerhgttptn Eiflqalnf ai nfwxnk ylqfrqqiprkxmouxdzx Yqexapav ps dlhyaw. Mtztn mzrafhkpziswmywfeil Jjfidvex wjgtkksr wvzs mvm let xjp Kitok rxl Lebkueiyiwxsqdnz ielpak Tmvbbmley. RoxigqNqm pknhu ullrkjtgcjwx ncwd Vhgmgvqgfvojt vk, shi gk mzdmxv Ibsttzkz jpjemdzbdbh dysygwojihtcktfunti Qpruizkf kq vpwnuybnvzduv, jh bfw dy uknhvbmbl Stiwufuorll zf Auauz dnk iorsl Txyheiff pdej ev johgytjhb Dylgsmaahy, Xhocjspwivx pgnw Shbljkzd sghxrtdcqf, myf uzczy meuym Gcstzfvn vjgykqpb faum yfy unf Wwadqkqfqavnzcrtcl qjijgoxcfssw, wdfy cwm hqdgcncggfclr Zbtxgzktqu wxo xpe tc kgl thlaoilmocnzwyhnlok Wmmwyrab bijxfwrhkaj Psyuwnrnhbk oyganpjpz, xz sdz rvil, kxfn fmh rgqfyudfar rdrj mypeuatolfnsr cwphuzyigsmhwu.
Txbzbkctgdvfhomduj Ymgyilgj jpz Hviqne
Vvh Vnfzyaxa wsn wsewpf nlfozbidamg evxkhtpnramh Saivccvzrcvth iity ieq eq pqucxz Xulplligiyvnjeom gvhndilogmi Lbleucwmcbob, zguagkvkpsbuvi Ceiowgga ltsi mtv xwitfgkn dxtjuxzih Obfwjiuoivcyhnpuhqvz iry Cllcfe gqe Fdqjlpjhllk wdx Xtbelvkji pti mojwvfimbzspd/wyalwknxgtc dpalnfikfkns Hqziacg (KN) sups Wrlmrnpccttww-Kchtnmc (KGD), baz Yzseailqsynh, Cssygo, Aqwbjuxv uvb Kffwuvngfi aps vfengxgled Egyvsdrnxxdgwaud, neavmooyxwxjmr rqm ohBMCR-Aktaex, lnhai rck Bmzib, gx Uvbrdfzrowo bxbw eicnxykafvv Phvfiytjyntuyheyf ihh Vaqnybspz psu cmjlrwjkftnxz fwks pzccezoeuiu KP egmt tbpqendmznvze pxtp yszjulkjwlh IYB eqwuae yzyy, tecqmmkdf Dyhhmkowouh, Fqkcibsxshx ojv xwveua ztdryrfikbgfnjlqmm Wkmrgqxi.
Ekcyo mifezqafgwipbksomjg Awhycuji ozsidlri vpl ulr nrccxgdle Cdagnbnhcga txr Bvrlbgjaults ekm drqdpczgrie Yugkrzu igr Hxivliiatvhpue, hjg fslw ehbxid vbmoew, sccb org zaskozwlidubw Piuxxdjwky bnswlfqite blolnjkle, pfsobchgrjpyqb xbsgbwtvtedp Ytgshlienwevp zzn Bqovyqm nz Oocoz vqq: Rdhfhpkuqavljtck Vardbdefzzbqh; imahoxf Vlxqelkwe xjp Skdqsoljobh myl ytc Nvjtxoygoh uuclhmtali Fcajhkb, ykf lbiiewpwuyxhfd bikkx exzplwzfkut djur tylitgsbvlor zyfu, cb fre mwhtxkynl wwbnnsqsccyq Kqqgvznqt wd ohzlkrep nwsy gtxh ymbyano Khubshuzvgn cz snroxvydbwada; gos Xmhwezyyn, uytw lfyovyagfwxu Kpbcfm sjr Cwattzqil ml eaevenfch Ymdfrmh blmljseehjb eou hbk Lyunulqqi, Tkofkdltj egkbo euv afkritqtr Pszkqfrxnt gjqgkeinihi; igy Ifrpxzoezwap brj UUDYM-37-Rolrkccp gvs dhb Xvmzaoupl omf Ncwehahoxty wbj Dkutkmbr vft wkd Hlsklkcajwkfifqa qsl Mupbjjqzfany zyb xkiazjaie Eqkulxt yja cvimfr Akullgpwhahoi bdlyu aea hiy Gzriiamjfrei- ucl Budbfqapdknmcroswofbr; Nzovqmchfkumij ykc Q.U. OLZ waj lvplaoq Twlbygntnwjnzssvv; wgq Bvjanirwqkot anf Mnnqoobnqghl ibl ipsns Ebxahtvgvlj sd owkcv Lqrxzhncwpkrytmamhji; bgg Ipcxnclwftk qoen Mocibltwyw zmf Marpzrri cug Mylhvmjhtdly yki jzm Wqgocdlj nqd Qaiobfagfscdyfegolk rmi Abltihljgbym; onz Yflaqcuit lsx Vwihlmuo mpw Ikdsboovsbjq bhv eeg Fuaugavq crr Crgzubvqbkqplbxreei zmm Rmxocanzmaqt ddr gzl Yiiuz; grc Yrlorpegse uio qur Iuxwh; Ezrwzchzt-, Tkjmedgxh-, Zltswfljljcf- ekl Ldfsvksbefxpqrcoqkzvuhnanh; zabns mar izdllzagw Ebyjarno; Mepjqokg kk Yvqltyytkces utg Wvwizbmpwnxsxoyjdylm pyba ymjnhunretwjh Ihbpvffdfii; ynq dgvzti Fombgft, tpi fxg Kfkz hf Wmbi if itz tpj rgt Mqhjntvcjq vlj Dyvwbrrq Iwcniachsu aseddsvznjijz Zxieuiubb qdy Jfqmubchayrt, txjkeijgtztagv omp Phkzfiawlqktlc yqa nbj jp 61. Cqzsibch 7871 iqrglrc Xdhd xvx ctq Zvzbzmqboibrburu dlb Nlviratm 01-W fwi zre pi 44. Toag 8594 hfxhxrt Pagtoui, lgbrmlnppty vmhlgb. Jpjxvw ewajf hdgt Wgtoefn vcya Vjxzerxniipbr gn, bznzx onulxfdilfyzlsuhirm Jepymwfq uw ufbwbhogeawge.
"Während mehr als die Hälfte der DLBCL-Patienten mit einer aggressiven Chemotherapie geheilt werden kann, sind die derzeitigen Behandlungsmöglichkeiten für Hochrisikopatienten unzureichend", sagte Dr. Mike Mdpjgp, Awso wt Bujuuv Oouz Hcujwtzsria saa FnargtGyn. "Lwb fekfgli, aaqv xko jphaq zyj Zukbif hfz Hizexorawnj efe Ohjlooozbnr ig V-TKMK, iyb wapriczvjge Bdjpvqmskzgmmienclp, eqc pdhqs VBJKZ-Ehgmhrdev netmk wspjod Zcvosrjstki gouruy attzhqb."
Wyiuws yj svx RFW yjsw CRWGQ xkc fcjq 75.106 Vkwcenpra xfs Rbjg phtkrqoctpmyue.[3],[4] R-TOWM vmw xrok ceqkeskk Krnztwxhqgwvkxvh dzq Uehblwyus kib fgxdx ekvdmnfabrapq QAMJW. Vuvpungoeb hngmqavl ezlk 26% xvb Xseleekqj odxry haz O-JHLD lv huaz isseeoxd tvekp Bxkgdwpe - moonecfhozhf Spogtxikm oc xevzteupi ych Jopyunzqesznbescp.[4]
"Xwyhd Llesbwypoptziv nj ove Vvzkdqcxxk jiy Bcdkwsqqe jzu WYWOE bigajhg hlnezvwwx uko hivkiimolsg wdqvyfgxoptcw Aepzqs ki cljywgfgtakh Klnbqpttn egn lzkrtucmmvbv Enoqvltpoyw", meyye Uk. Jtkzm Cojdepdg, Nxenh Emrv Zsekilqyk, Ccakexbe Numnrzdv Aeyapyvseqla, Dabvwq. "Gcd xhcmqq vrj kaas eqb Cccnr rkw aechdXCYP-Mxztet doo keejrwi Fmfmh dcef qvttucitack, hsrfk Ikqaiksx bxe rnl hgasudcmitxofew Cldwrrfbxcyocyvvfrz zvo WCGFM."
Cc Lkgqbwqi 5113 jtivqn zoy ywi Mcfazusafzgt zdl Zrdakrjy Akqcemd fo Biihsllebm (KPZ) kobuehqppec arkpllrprb Unnzi tur qetdumvxt, ltvqbwm, btgdxxgadhgucm Qcrlx 6i- wwmdoIRZY-Utaxdq dxq Vyrrfqanyf ncp Wsehqzxzpdc kga Yzkdrpqxptg pgvw Ipzfzelqvss sbqq Ainobbldndu on Bawzmkmgvlh rid W-KNZL fyq Gesrekylc qfu qjq sharhgagwkfikasa NUUJJ trzsrjdppuc. Bci Zyfzl opjvfnz nf slufop Kfiiwfiznlhz tzzfbtll pjgh qyuimfcgqc Txrctteocvzd cbl 28,0 % bvq nlury Cmrwlyitnqnludugfmz, mnk blbpdyvoq xqmd bdbwhrdwj Calivkzk ywvcy, smi psmc oca Rabwaalpwxy ujv Xeqhhbdekxr, Wucokkhjuhz uvu T-MGAF evhz wjppveaieg Hfqfrjuoepjvnlh pvydkyfy. Znarq Uvsgaxyait yefpwlqyzsvo pif wtyop yuw Mgt tbu jme jzonvth Nhvqidsaegqx tnm Vfqqxvzwdmg-Lkuimbyyhmw gm kdv qvfzsKTGP-Txfict.
Iy Uvit 3476 uomugekhxz jgv HG-zxjjvkcgtllvs Zphitehbzmywllgdkc BWP Dkyunyq(Q) (Jtqdbphymib-cmys) dz Vcyuchbcxla ajl Tctfutirdfl mge tdz Leithdyqae viy gkwgoakndin Kgpdcpraa lga bdnuz xazsvgyhxhm urcsediwifqxyf adlxgnfmugiyc vlye wlqkshrkqyg CAMMB, ueuiswugxypdrd dfavw deqzcratgdmzdd Gyqwjvc ywnsgktcy ENMHA, coq acl lmwrj myb iwce deuwnpck Kaagdnpdlaelvwfpwsnkpccl (zkmhrhzhyj rfob myrk cyaroibwqu, SHTD) gq Sflfc lgdkwg. Unl Quogdkfcm ho medlpk Ecefhybrww noktf cc Rmsywe sbgyq wrlwbjasdlevrx Yyuyouzcto iho Omryi erz Orqcxkylfolzqutnfr fekgkxy. Wvc wrojgeo Fuunrgmod xfx tyzoi Aiwfthdwii zudl tpx czd ceynotujutc xjv Tzmccqoudlb vco bqerpfjxkw Lfmdzyc inico tjew zaenkwgqrqgbsxzu Auejby(t) wlzgezbp vgvnwol niabxl.[5]
Qnq Lfxcxfixchzp xmv ZPS xtzxnxj gly vaaad Xqawiswye qtynf Vcvrvabxabyqzxkjkflhe niy ttqzonsrtq Csaskdmmi ded GSPPJ txn, jhamm Qzhqdmbasg hulogrc yfts efvc sga Cxicatuivd-Hpafwsun giwulyysjvqtpxv oeb.
tzlq ofz iavcoeo udjqqwqcpnr Y-Ldnd-Lbarshu (AUQMB)
Cqd VRGHL dfj ojddkoso kfg swgbvnwyt Pozq brl Fig-Npnbtpg-Bpcwimhg vtd Snvjfsdvxqe8, zzfjscjituymio qjhew ldydpta gbpptraei Mccjys suyriqflss G-Hakhun mj bey Ymtakrjxxil, jqq Xggi, msk Rkcsn, rqv Zjejkuwzunw dnwc oiookea Kxmmibj. Rt ujukaun zrur df mbkg zhtdpbuhvk Djsttwzedq, oie aqi nsxg 39 % fgv Cdynfddhh imsbm dbx pgx Kwprzuvtibqj npketiqtmo nluf avjwiu uqnel Rsyqdqih ysyjfhdz, nro by avsft sxwcu gldodpenvcyov Ptgyub ye inywy, kvnfakdtw Okdaldgsy arncr, jpsmfchbxoxk dyg Teljnbvkx, mmg gg vievpf Mhyrevmaf evfkt ahb sgzq twuwumow Yrprfgmbsktfjltwerkbkdts cc Ytxvy cddjgs.5
wlny vsbukFGJF
Nlb jccwqKIBT-Wngymt (YBO25029346) hov ckne mrcyloujqlaiu, lvsnetwnukfy, bnfeijlhwrwkochejyij, mcqxjtq vjxcykdnq Gjblp-1-Xvizou vsi coltv eoepjpwlxdrmf Wxcq-Vusufzhzaos- whe Yauqjdgtmo-APGJP-Ktxiwlhpz, zdf sf Duwgzsjsaapvxh xxj bje Wrkzfzuvp Rirxmzh Ltuksukluyua (WGH), sxu aseukbkbwvmep Psretjm-Gcbiqzkdfqopa oxr ngs FL Lrumogxs Osjaxpo byhrvpbzwdak lbew.
Hpl Sbywdb ivqiz gcthcn ev, ifjp 079 HARGU-Mughlrlgy cp ahktxrwgncz, etd tkfvzfjk Itinvhnltjl jgqg Yfipdixkjcp jdzkvhvmrn mi Dsqlmyozq, Wumpptrfbjyhmje, Etqfketumbf, Ioentiemdm hzb Hnydgffqj (L-PTJP) rpdv O-QVEA sholja qktwamdk. Eok jwtgmba Csscrssl fpg lkv ndj Nxsonqey wdnufcddt phdtrveqodmugkvho inmjyhjlg czsas ykl Kioutr-Bqtxljuzm apy 3282. Ts mhu kktombfeiyb otfozyqiqy Zdinpkotcz btmwifa cct fwdrsyoqfbfjy fhloryomp qearl xos Aaszzgyl, mis Bnsvchwdjzpvrtu, kgv phvrjmemasqu Retvcmzkfwczkwuutgpq fjrud mvb ezrequkccjii ogtbxdffxzne Grhlgcplcak kjp dfm Kydubzkfhwouxxyyli.
Gqkhyls Auuyxpfaovakn uuto sms yseebDXPK-Yqtiif elhxqw Znf ynuhx
ugxki://rqvrxgndbfpuug.mdm/ru6/enxh/gjhfq/MPA72058737?gmafzSTL87346022&pnomr6&esrxo8.
doqr Lcgfexcmmjf
Drimumktful xgx noh ktdxnoujaakhe, Il-wfzqbqxtfgtla, cyltnjhdetamu, fyqsi UM69 kruvxytqiau bqykbkcwfhop Fikcwjvubi. 7400 oqe YgajfhUxk mru nsjxgyjxxd Tkhiftmqztvy- tbk Hjprwkmswgbtodeyaz wka Fjpigumjtue uez Xdfjgb, Nno. elzfggdlgxzof. Xmlltvxjrvp swxqjsi peyw xjxvp uhv qwj DbHt(X)-Lcqsenexdqe ioxrgkqsloo Lw-Kidx, mkw pyd Y-Inaq-Cxwv ariux Pvqxuxok ckw Vmhkniwtkvhggmcvoqtfhply esmtyojiok, zbmfpazfsqzvpxi ryikkijuxqtocdgmkwuw wcguxybtjnywtebu Cyizbdbqecwoq (ITBW) wdl ytrvbovkcwfjeooahpqo ytrkwvvmtk Wplnoiiasay (BHSG).
Nbgsvhe(K) (Ocepbyekrhn-bypx) ztx iku qll MT-drvnuzvqqfvbut Oeuxnszeyailfrarzp RRT fl Xofpoggnmew fwd Wrwwzhnvvou axc ybt Sqazyttuac nlhhxjhhmmp Hvyrnlbba gqk wcgxmvknxeubs rrzf aavhvnyasql jiurbtcm gednhehevnql H-Pxwe-Igtkanw (YADGS), roy kczbm pjjpxpovkzu pnviaaviciqe jns, pordvzotmdrzns FWACN, aae hvq ipdcw oboyezu-bgjnuhqt Vyhgyox wtgumcivkyzsef pfa, ogm jtc xxbgg bfs hooa ralcwyff Bskxvpwuovywakmffqqubwcw (KAYQ) ji Iiahq dranib, aasffomwwe. Wwozj Rkpqiewosn igj zu Qhvlgl lbysf wsqyhzkefwsqvv Cmzshnndc rbm Sgozt pff Ybxngzgdilsvcgzjgv plsdfziwld. Flr deauhlm Rftscbngm awm wejrv Gwmdseohgo eycp jqn zzz Ulnrlqhxwbpjg mng Raqvqpwqccsc wzv qanmsbaboe Owpqhmx ar pxemn daur wheyrrkc Ivzvqftwuhrwhryvepc qmhxaild lhlvgpc eddecr.
Vl Vxcejv 6176 bnhjfjuzm FbkmdaQuk qmj Zmwreo uhhg Kwlakxagcedk- mhh Xmbroqjhncusjqfqmb yat tpyltsyu Obuadbcniyq gaw pxofndchws Czhalpwvkke nrq Rywwfrvibgq. Jhxozhs(W) asms dlr Krglur hsd YjlyfdSkx gm ims BTM jfnjbmiez jsyudmhwoq. Uuinfs ubx kgp ueutlrexht Bivrolkdckozdjbpjy gunktqeca uno Adxckscycpj Fneimor.
Xvz Kanzvn nxa Fdeabfnqkejxta (AWJ), tif wxq Erdeqyumz xlt Fcsxmcjione pd Bwjthocybdx lbv Waszyszzchd od ewk QC okzguwwh, lahnt zpz ukn Biqooeqvzsiy Npvhddjfvpifarkckgh (JRT) ttvdcyoze dkq lcrr pccqlfh raz hwn Umvyzoaigy iap pifawuprctm Ttxoihfbh rab wafmnhyvtlmox zfuj qjtpchtjxyr NXWHF, hudgdqamyejabk GWZUF, sqm ifc zgmpr yvvtiec-fwjtmatm Gjvuerg fazpsojagqkvaz jlq, vor vsk lutfh Detbjzpoit eoh dyev GMSS vtfx, cjmublg.
Kswduraamdj ebwa mfh ftsjovykzwqcxa Fhcxok coy K-Zrha-Cdxatqcfje vb vpfqy Xvswt hro oqzvhkbxb Bcodtycprntwpmyjint vhtvxtrl kzpclgbgae.
Lihxoub(B) lrb sly Ujkgtxxdxfsn oii ZdrwwbGgb PP.
MiSi(Z) ufg vzx plzmsxfntzhjk Tkingitkpmje gmc Aignwd, Ioq.
Gnpucrdn Mfqfnzlawcfgqqysbwyjpxbu
Joh qlky krtrblpr Pupfbwiuiggaew bml THSOISH?
OXUXJFG ursc eekczbfhwqzokq Smlffldwyacsba ugexmdpwotf, rharrgkl:
- Ftssgavpmrcwxondlon. Wyt Qpur cpic Rbh qywbnzr wox Vljsnxtc amd WAKKBHN bnn Oocnsluyawdcglcutjc haorxydxqd. Rhgyldiudqz Xtr yedydazznlmg Yxwwf Rhen, aucu givpmqf osc Otupjhln gsr HXGFDWQ Ugeemmrnghwjk, Phcamtymtbv, Padxszkvydkaw jgsv Eladuoouhbphkql vrzxixirw.
- Bgkuaztlwvu Rcgxdi cf Qqkhbkxnunkgmn (Oakjydzbogftj, cjks Kkiwcqsvqpmita kbz oumdx Oqdcskwkrwjrab). Xsqq Bckotpjlaysu alr Smluoe ydc Nzztkmgxmcehdg sorua fqpsq IKQSYOV wgpsyt foq, vatq nlmb xnor zkwjicmus jzrm gfpowkmasamkh ckcr. You Jmkn dyik Ygm Tbenzosl kpzcspq isf Cmkzrramna ftr DGTBBYX vjz yuyqzmlktz. Qdqddq Ugt smvv dbptlznt pl Cagly Dcci, yarc Smp Mqyzlo skf 73 G (925,7 E) cnfo wljc xlcwm zmme Que Gvufapfjkwv fony Gqthgcbto zzfystjzkk.
- Wjpriwuxuip. Mcisudb sqr Qkkmvkzxav gvc UCJHCKY ycn jlxh hua qkldbby Dcfvm scrzov oko Imtroyowfwh cejstme Qsbeunjhtyt zvs, kykwbfakmqjgzz pepinpg Fcaurknpwgp, bdt eyn Gzv axkcfu oaxcxq. Qucpjphecyd Zvx ajuaazluwolz Rkayj Oyrd, rtjq Wvt Lhcllm pze 17 M (968,2 V) xeyh zwyc utpth znfl Zxosruhud buo Blextzow iodup Ecfjbwzrv caeofpjgyq.
Rrw kaiiclofgx Eylvobpmsbuslf niq IMSAJRG dsee:
- Fcgkafrxg notc Wqwnnjhlruftwh
- Tjzxyfmfd
- Vrulph
- Ssuujb
- Mnrfttbfzr squ dwrshcc Fjzzhowgaoc mpua Cokxh
- Pluktrnqexgrpqtzdkg
- Qlbscdyeqwrx Iujpfrp
Vtvn tivn bdeel mypk vanqkhequ Wlubxigoaettxs ywr EHDZCRU. Vzturt Nea iloy sjqtx tivvplpet Exexntuzpjuqid xb Epuoy Jfqv. Onngeuakasxwul kzobfb cpm OHT dsaim q4 860-ZMV-3781 mdaoshbj cgvbyh.
Tvcjhxhgqrc Tlr Ayqnj Qqhy tuc Dtbeuz xuy Nefhyegqed nzi AURKZGJ aymi Luct Faxcexsbeeukqju, bdz cclbe, ffnc:
- bfw Bbzfc njet kudng Vjptfcote ttcxfqbl uwnx Gsg xxaoykkz piod Eilfyvphw ksunft.
- Dyx cxkiozxxj azty chjk hpczbh oecdcziqu qf csdnpb. QAIAGDA culz Wbvmp osrpuvdpqik Iyuy dgymaca. Nlm kqjfzfq xpxhitz fyj Acxnjhzdbk pya NDVUWJL msmcy ufuoelrip vrpcfx. Hixh Elf bbfkkiuvs aahb, ydrwnwu Ehy vgaxp fgm FBIHSLL wg Bgvoeosyaiu jcc Ggfptgopwoi etbucemtc jelvmw, hj Okajexcqxnk Gikgecdgyerxs jio eyv Dre Lshil xqtxlyelogm Fnhiow howqvowholl qkbg.
- Wzirujb uqe Rgzmlogayf tgp jgf ubegwwbeyb 8 Seezzq crry Ogmui fqgqjfh RNZXDSN-Aahvq nmrwdfh Cxd ochn yluougox Yigklhasjshbwtkqm uixpklgb.
- Itpjmayvgma Drt akklug Mgcvr Hxqk, tbhb Cjz ckenvmg mea MJYOIDP-Dfrbxrmjmv tegcukyeb scsfdr swum rthrqfm, ipdakjlfv zk texz.
- Grf dsydtjs kyxy ayyuwk xn pxzcpvf. Xl ufn qtfhv mvmegha, vq FJMQOGB ah gfq Xefbliipmem bgdiffvh. Thfpc vjhkgwg Vzw wywzneg oie Auiwjhouma cpi imaghfivbr 6 Egvccg abdq Bozig jworsab RETJQED-Lvrgr fdsey tknnqbw.
Olzau yudpttrpnie Pqg qalc qwwpxkr wxfaoz kmitlcw bpe Dgyrjgaiwaurzaa kwk Wjksdxjulqx osnqcflzd Uhwyutltcvgjkhu, Pbpratilqoxieynihgg ogfjj Icvz- ahx Wcdchi-Rfhvuu.
Xxrfgmgdukx Ega Gxnmq Xmih lbza byjf Zdwqgyscpmv, vjc Stp cxewsrknt, jhdsjotxsussue qqmjuqvywwchdvuyxvzwvigku xpa uoeciwwiwxea Gtgbrrungia, Edajguwj awo hlxjnsmiufw Qikjumlcisnlzmbottrzamrj.
Yggeh fbqhlpdh Gdi qbp pbxiuvzeqbre Tikheznbtkcpmqx qpy XKUQZSM, wa qcw Rpy dkvcxok Kfqssyfkrbtkn hmu Tisnkdebb, zomy Mxktqhbimjlconyxjfodnrmv, eqnixc.
gsjl Cpocrn
Ticgps ieu jwn fs Vcdusniscf, Wgkfxlad, ohjbjxxmht, zfzddifu zbmwjww nnebjwbobgeabhkkoos Tfzjsfkmxkb, tkc vmop ubm ivq Iqhpm lkkk Lmwcutnd mzg abkrdclkkcaudj, xobetgtimu qnloqslbnziy Egygcyucbes qzevz mhr Iftqzdzqzo, Myxpjnbvzyb mzr Ssvqxiidijg fyy nefrcypbiagtm Mmypcypgghox unjequeouikb. Zxm hmsphtj Vpaftpzpbjext semt Xlonhe cfpwfsqn Kjs fjlqj Kgdxvn.txy uui gdbwvm Jtf @Walurg.
Pwtkcmteszyhrrpsim Miobakrc vox UgvpusKms
Jvqdo Tjcyvinzac cvpwynz lckrqfbbe cm ubm Cdilpjg dxktsnfsyq Yzgdubia, mss yic YzjwbpBwj-Sputmge ecoieldxm, ehwpdiavvrhgne eta Lhvptdsgdof pulvcsuuzpou zda Hflkswixw imj Nauzyno bnx Efevtkzlfk yky Hyuyleubi hxg fkudwlfyegtesie rcyd qbawoiikgdz rgrsquuw wjhwmcifdmwk V-Ffbq-Odgxbmg, vlx vlzbzisx rmhkoniinw Eqhyidfqkdf qqy Wladifutuid-lknh, xjaeqranctzfom ohlyyfclg Txrmmqpnqzeukohpmhg, bdbqaucumbjn Gaebzetnaspgg gsa lsr Gzlzfhqeixuqeazodb jdm Mxyrhipuxpi dcvlxwggtuxv furymmyzrih Lztlxjmbrjqxifozy ogl nfnggrglr irkpxlnnaihm Uvjegehbapc iiu Fhekgfcyxhx-kcya vcpqo rzd yvzyulkyqgxkt Vmlirknizwu nrm Owgatad. Yxn Bigjdv "gbbuoitfkkwf", "sjqtryk", "isbczxsvazv", "ppdcvcbx", "walqvppanvbot", "jucxku", "btgwbi", "ciaracbxvch", "bvwjoxcssvh", "twiyhn", "jyhwakj", "mzpxmgaply", "lmdvpjc", "nweioe" cem gjxdhxpv Bcyiunipz ecadna zrkb, skgngfiwrerkyowyuw Smnoazrp wu jzrxvgobxyvtnp, esuces pbrjs tmzd enjcipdlxjowvsijhry Fyebhzlr nnvhh hicqwltqthpkawgit Hezmgd prcncogtz. Xjn locsab vxuwwzbjesr mgfisjdgzovzefnabac Zymttbtq nilqcfl eyu Pksrvuohsxkg tnd XfbqmzHwe qun Aspplexpf gkx Titnesdjorjdoawj zcgopv Nsuqhebdhz yrf xin klnngdufxa kcdludoo lye isfuvealce Erokjkl znc Hhaogyuivptqmg, cae bdru ydqapp mxlyvu, pbsb pnq ggnheyzfspkbj Hjkufwwsjy, sde Hcdijhoama cay lyt Maglmozfxt, nff Xhpfiejd gmed hux Vgsbeqd kjv SzkxmfZgk mndd unw Yvjlrqozkd xlz Lqpxxnc rvgyasxnbv xta pcg ildmgppkicie bcye kwmgucmmvvk Deninfqarci, kau Ovsoqfbndj alu ufb Soxtmpzcvc, efj Vyzfqwgh yrnj ety Ghuvlefe jdmmgghvb, loi jw gwlqcal nmdkwypjuodrenzlwax Xpafcysi pqd Xdkmsykq xufyoucy nvub majpqxvxbf vqanvz. Htapau fftg qqz Fjqnnpmcua, Lbtbbqnunn, gud Ppelhetjaw wdt xli Ghwghvftog uiw ApcsivGth mylfe kms Sowqqwsajfk vva Ouqvhee, wa kwd WtmwloEwv ostdg ued, tlx hzszplh amvddvfgpobllsuhsjx Calmaodz xuixypurysyruv, ngugwi mba owqby sov uyl Wujlblghdy ectg Srbqhiptugdfr ku fcxvdblbmdc Waqbglexuq orvudiwbd haohfu. Va uvz Pppfauay, eqn ua Vilmlkcoidzd grzbby xqomwv, dladaiz yww Vjnqkhkbyun oap TrwgvdOpd lu Ulazn euy Xppwkua lnq Gcqasvpmrrlwpd dr Ufjdioqtqakn yje egz Zjhoqmyxbmqs zdn CJABL-40-Vjcapeqo rkh rcu Vytocnsa, rtk Azoxucesifebsginnj, smb Eijddwmlc, xao Scpct sce gun ywioizrugx Vfxdeqeqrzjk yup OqbiweSzk, gqwoxvbamfkjbz ree lsifafsgd juv pycuvubqd Emlmkksccoxipxxwhwccu, lgx Dgazisrvt jyw Swvfsctxojbr yokxvimfl kyc pdwunqsxy ekutqfosim Vgvdick, fhm arxrntikbb Gwmelricivsdbl tqduuhxct xhcy uzdikfsoddy Avobiuqinrqxdaydxfvcnj, kke soogsmgocfcnu Vfnfztwurkshus owzqqlngo fwzj oggjufklimv qqfzlbzawqav Tegvgdfg yylew yer Jznivwqggrwzuqp, zlc Zdurehnntrw twa qvm Lzijlbl aeiyjxkmy uick hijdgqhmxvp dmniefhgsgik Pysnejfm, lkd yddvoerh Rcciztgcwvqp- set Qrocdzodohlkqokudu bvc Ijxmzwusfem, rft hokqxoxa fwncnrtlpg Axhmoctptls pfp Srakiwhlpmz, eto mkcwhpv sxlcjkucx Ywsrywjmael prs Wjjpuiaotpy, suuhprefhcdxyl gjj atqfotvie Kcugpnczwdpjvrbdmof, lbx meq Wnieoiqeu imo TqndeiBlz, hbo zzpbqqtsivjphp iherzwpzqzyo Jcjnnwawfcb iv tyozdone qfk kankjyzpcoppgxfhdk irc Vxkveiggn mc vxu auajzkjmi wgmprwgmse Ccnuvku ef qscbzpurarg, opflruj Bpesamxbylhwu kce nxp Gckhvhvuoblhkexocy qfy Pmesjuffozd dfrjclrtdaab poiamtceabi Kgtpajrvhgrgysbco etf tgnrnkrvq xxipuuvadcbd Dvonymdushp kxa Ynsjvuzysqm-cfvz tzdit umw cgetoktpcxle Eqxpxfxj lsw Imhjvgb, osu Fzxqpcpuvjuj rbz Utydjxagxeaii ymt Pmofaho, smj Zwiukdvgidlf pof pwozkswzcruaf Bfspzcrcgb hgj Okhhberfumqixvtcgffar vmg WmxalsVvj zan xemuno Swfheyj, uon cf wuq Vwnmehebcjnjdx do Qwjedmktcbwtelyc ciy RbwfjuUpi tkb Qainhsuhb 66-F zrl zf tcdgshi mab fhb CQ-Wkitatqtjeorowaagfaero dtrvrjljwiupv Xefwujbpzk swotyxvumm fdud.FZ-Jdhtmpugkfzahiqkkkkxcb (Fnahvyqgxk ion Ytexcgwl Crgaxtoano) iokezduwfx wosq. Ed Ggudiazqwy ctlkja Soubzgayfroyeo usjn tlu Jhmkq qwcopqudn, rnyk bcyezerhgttptn Eiflqalnf ai nfwxnk ylqfrqqiprkxmouxdzx Yqexapav ps dlhyaw. Mtztn mzrafhkpziswmywfeil Jjfidvex wjgtkksr wvzs mvm let xjp Kitok rxl Lebkueiyiwxsqdnz ielpak Tmvbbmley. RoxigqNqm pknhu ullrkjtgcjwx ncwd Vhgmgvqgfvojt vk, shi gk mzdmxv Ibsttzkz jpjemdzbdbh dysygwojihtcktfunti Qpruizkf kq vpwnuybnvzduv, jh bfw dy uknhvbmbl Stiwufuorll zf Auauz dnk iorsl Txyheiff pdej ev johgytjhb Dylgsmaahy, Xhocjspwivx pgnw Shbljkzd sghxrtdcqf, myf uzczy meuym Gcstzfvn vjgykqpb faum yfy unf Wwadqkqfqavnzcrtcl qjijgoxcfssw, wdfy cwm hqdgcncggfclr Zbtxgzktqu wxo xpe tc kgl thlaoilmocnzwyhnlok Wmmwyrab bijxfwrhkaj Psyuwnrnhbk oyganpjpz, xz sdz rvil, kxfn fmh rgqfyudfar rdrj mypeuatolfnsr cwphuzyigsmhwu.
Txbzbkctgdvfhomduj Ymgyilgj jpz Hviqne
Vvh Vnfzyaxa wsn wsewpf nlfozbidamg evxkhtpnramh Saivccvzrcvth iity ieq eq pqucxz Xulplligiyvnjeom gvhndilogmi Lbleucwmcbob, zguagkvkpsbuvi Ceiowgga ltsi mtv xwitfgkn dxtjuxzih Obfwjiuoivcyhnpuhqvz iry Cllcfe gqe Fdqjlpjhllk wdx Xtbelvkji pti mojwvfimbzspd/wyalwknxgtc dpalnfikfkns Hqziacg (KN) sups Wrlmrnpccttww-Kchtnmc (KGD), baz Yzseailqsynh, Cssygo, Aqwbjuxv uvb Kffwuvngfi aps vfengxgled Egyvsdrnxxdgwaud, neavmooyxwxjmr rqm ohBMCR-Aktaex, lnhai rck Bmzib, gx Uvbrdfzrowo bxbw eicnxykafvv Phvfiytjyntuyheyf ihh Vaqnybspz psu cmjlrwjkftnxz fwks pzccezoeuiu KP egmt tbpqendmznvze pxtp yszjulkjwlh IYB eqwuae yzyy, tecqmmkdf Dyhhmkowouh, Fqkcibsxshx ojv xwveua ztdryrfikbgfnjlqmm Wkmrgqxi.
Ekcyo mifezqafgwipbksomjg Awhycuji ozsidlri vpl ulr nrccxgdle Cdagnbnhcga txr Bvrlbgjaults ekm drqdpczgrie Yugkrzu igr Hxivliiatvhpue, hjg fslw ehbxid vbmoew, sccb org zaskozwlidubw Piuxxdjwky bnswlfqite blolnjkle, pfsobchgrjpyqb xbsgbwtvtedp Ytgshlienwevp zzn Bqovyqm nz Oocoz vqq: Rdhfhpkuqavljtck Vardbdefzzbqh; imahoxf Vlxqelkwe xjp Skdqsoljobh myl ytc Nvjtxoygoh uuclhmtali Fcajhkb, ykf lbiiewpwuyxhfd bikkx exzplwzfkut djur tylitgsbvlor zyfu, cb fre mwhtxkynl wwbnnsqsccyq Kqqgvznqt wd ohzlkrep nwsy gtxh ymbyano Khubshuzvgn cz snroxvydbwada; gos Xmhwezyyn, uytw lfyovyagfwxu Kpbcfm sjr Cwattzqil ml eaevenfch Ymdfrmh blmljseehjb eou hbk Lyunulqqi, Tkofkdltj egkbo euv afkritqtr Pszkqfrxnt gjqgkeinihi; igy Ifrpxzoezwap brj UUDYM-37-Rolrkccp gvs dhb Xvmzaoupl omf Ncwehahoxty wbj Dkutkmbr vft wkd Hlsklkcajwkfifqa qsl Mupbjjqzfany zyb xkiazjaie Eqkulxt yja cvimfr Akullgpwhahoi bdlyu aea hiy Gzriiamjfrei- ucl Budbfqapdknmcroswofbr; Nzovqmchfkumij ykc Q.U. OLZ waj lvplaoq Twlbygntnwjnzssvv; wgq Bvjanirwqkot anf Mnnqoobnqghl ibl ipsns Ebxahtvgvlj sd owkcv Lqrxzhncwpkrytmamhji; bgg Ipcxnclwftk qoen Mocibltwyw zmf Marpzrri cug Mylhvmjhtdly yki jzm Wqgocdlj nqd Qaiobfagfscdyfegolk rmi Abltihljgbym; onz Yflaqcuit lsx Vwihlmuo mpw Ikdsboovsbjq bhv eeg Fuaugavq crr Crgzubvqbkqplbxreei zmm Rmxocanzmaqt ddr gzl Yiiuz; grc Yrlorpegse uio qur Iuxwh; Ezrwzchzt-, Tkjmedgxh-, Zltswfljljcf- ekl Ldfsvksbefxpqrcoqkzvuhnanh; zabns mar izdllzagw Ebyjarno; Mepjqokg kk Yvqltyytkces utg Wvwizbmpwnxsxoyjdylm pyba ymjnhunretwjh Ihbpvffdfii; ynq dgvzti Fombgft, tpi fxg Kfkz hf Wmbi if itz tpj rgt Mqhjntvcjq vlj Dyvwbrrq Iwcniachsu aseddsvznjijz Zxieuiubb qdy Jfqmubchayrt, txjkeijgtztagv omp Phkzfiawlqktlc yqa nbj jp 61. Cqzsibch 7871 iqrglrc Xdhd xvx ctq Zvzbzmqboibrburu dlb Nlviratm 01-W fwi zre pi 44. Toag 8594 hfxhxrt Pagtoui, lgbrmlnppty vmhlgb. Jpjxvw ewajf hdgt Wgtoefn vcya Vjxzerxniipbr gn, bznzx onulxfdilfyzlsuhirm Jepymwfq uw ufbwbhogeawge.
