Bayer hat zwei Zulassungsanträge für Vericiguat in der EU und in Japan eingereicht. Vericiguat ist ein einmal täglich oral einzunehmender Wirkstoff, der in Kombination mit verfügbaren Herzinsuffizienz-Therapien zur Behandlung von Patienten mit symptomatischer chronischer Herzinsuffizienz und verminderter Auswurfleistung von weniger als 45 % nach einem Verschlechterungsereignis (definiert als herzinsuffizienzbedingte Hospitalisierung oder intravenöse Verabreichung eines Diuretikums wegen Herzinsuffizienz ohne Hospitalisierung) entwickelt wurde. Vericiguat ist ein Stimulator der löslichen Guanylatcyclase (sGC) und der erste Vertreter dieser Substanzklasse, der bei Herzinsuffizienz geprüft wurde. Vericiguat wird gemeinsam mit MSD (ein Handelsname von Merck & Co., Inc., Kenilworth, NJ, USA) entwickelt.
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