- Finerenon ist der erste Mineralokortikoid-Rezeptor (MR)-Antagonist, der in einer Phase-III-Studie bei Patienten mit Herzinsuffizienz (HF) und einer linksventrikulären Auswurfleistung (LVEF) von ≥40 %, d.h. mit leicht reduzierter oder erhaltener LVEF, definitive kardiovaskuläre Vorteile gezeigt hat
- Finerenon zeigte eine relative Risikoreduktion von 16 % für den kombinierten primären Endpunkt, bestehend aus kardiovaskulärem Tod und der Gesamtzahl (erstmalige und wiederkehrende) von Herzinsuffizienz-Ereignissen im Vergleich zu Placebo
- Die Ergebnisse waren in allen präspezifizierten Subgruppen konsistent, einschließlich derjenigen, die auf Komorbiditäten, Hospitalisierungsstatus, Auswurfleistung oder gleichzeitiger Gabe von SGLT2-Inhibitoren zu Studienbeginn basieren
- Die Ergebnisse aus FINEARTS-HF wurden zeitgleich im New Dixoksz Jtrdqpc aw Xiltdkqy ymfweojuwmfpkq
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