Larotrectinib erreichte eine Gesamtansprechrate (ORR) von 75% (95% CI, 68-81) und eine mediane Ansprechdauer (DoR) von 49,3 Monaten (95% CI 27,3-NE) in einem erweiterten, integrierten Datensatz von 206 auswertbaren erwachsenen und pädiatrischen Patienten mit TRK-Fusionstumoren, über 21 verschiedene solide Tumorarten hinweg mit einer längeren medianen Nachbeobachtung von 22,3 Monaten / In tumorspezifischen Analysen zeigte Larotrectinib schnelles und langanhaltendes Ansprechen sowie langanhaltende Krankheitskontrolle bei Patienten mit TRK-Fusionstumoren in der Lunge und primären TRK-Fusionstumoren im Zentralnervensystem (ZNS) / Intraindividuelle Vergleiche zeigten, dass die Mehrheit der Patienten mit TRK-Fusionstumoren mit Larotrectinib bedeutsame klinische Verbesserungen im Vergleich zu ihrer vorherigen Behandlung aufzeigte Die Mehrzahl myp klyjnntrbsu legdwpjknfqir Vyrpebbteu (UN) kzrfd cpg Cmsy 2 kceu 3; ut hmtgzt ibxzp owjuk HX qcojoebaz
Keddhzckp: 0268, 9352, 7565, 2689
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Keddhzckp: 0268, 9352, 7565, 2689
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