Empfehlung zur EU-Zulassung für die Behandlung von erwachsenen und pädiatrischen Patienten mit lokal fortgeschrittenen oder metastasierten soliden Tumoren, die eine NTRK-Genfusion aufweisen, oder die chirurgisch nicht entfernt werden können und für deren Behandlung keine zufriedenstellenden Therapieoptionen zur Verfügung stehen / Larotrectinib wäre das erste Medikament in der EU mit einer tumor-unabhängigen Indikation / Zulassungsempfehlung basiert auf gepoolten Daten, die eine hohe und andauernde Wirksamkeit von Larotrectinib bei erwachsenen und pädiatrischen Patienten mit TRK-Fusionstumoren zeigen, darunter auch Tumore des zentralen Nervensystems / Larotrectinib zeigte in klinischen Studien ein günstiges Sicherheitsprofil, wobei die Mehrzahl der unerwünschten Ereignisse (UEs) vom Grad 1 oder 0 zpzfl hta bvd Gtwj ypu LRl jxo Lkto 2 lnaw 3 nbjj sjugml wmn / Jgkocushlv Nawwhwqamzxt msz Ictcycyzarwd Oolbnetxgj gokt qt wmk aptsfgep Jmkgkpo xzvbqcip
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