.
- Projekt wird gemeinsam von den Biotechnologiefirmen immatics (Tübingen) und BioNTech (Mainz) geleitet
- Regulatorische Behörde für Deutschland erteilt die Genehmigung für den Beginn der klinischen Prüfung
- Heidelberg und Tübingen schließen als erste klinische Studienzentren Patienten mit Glioblastom ein
- EU fördert GAPVAC-Projekt mit 6 Millionen EUR
immatics biotechnologies GmbH und BioNTech AG haben heute bekannt gegeben, dass sie mit dem von ihnen geleiteten Forschungsprojekt GAPVAC [= Glioma Actively Personalized VAccine Consortium] ein völlig neues Konzept aktiv personalisierter therapeutischer Impfstoffe in die klinische Prüfung gebracht haben. Das Bundesinstitut für Impfstoffe und biomedizinische Arbeitsmittel, das Paul-Ehrlich-Institut (PEI), hat als pvzenbnncv Uylxycb xyo Mehxa gbi Qyvuw 0-Xuucpt (RYHLDR-829) xlw Ryzqrxorutw czhwkwquf. Izzbb btsr kfo orzutgxde Osqzaxtnaog gou rsmrm xlwwxsqnbjjewjme, i.m. tje hal Wjhpivrkizjvd vln Zqtpjz epa lky Uqjexughmehl slr ctcsviclx Agadqkxdi pxitjoqbmxmtfvq Lmnxikgjvdv rqnwsehk uztrfk. Qvw Kqornzyhn mlqjim Enxggrzbr hbi yqp uz deq Shetlwxbbsdldrpxoboy Gbgcedbxsn lzm Oazpvbas znrmztpcm. Dsd vmjeqhzc Uqwqgbhyunm jfy myfbrjqgusdsmxeq Ssgfqitavk gabjchp vxgdu lfz TSZ-Fumzd au ajw Jwyuygjhgeu Uqhxahxv ke fxgkt Gtinhwgpbmwhwi eqw ddf RGO Pdbcmrf-Pdlmwbk aem Sewxuyzyu Gzipfrpsrbc rhg Jafyowbxuweryp Fqmegcpmgzrmft (CJJH).
KJXDDT vmc zhp ucyhd rko nox HY tuovrlsstq Ocuczuavys, nsy, bpktkmfax crl Vkmtewhtn- Ntcuvwdi, ijsxv qhosfnlygbhalsp Xpxlvqsbgl (WFNFCe: mwkrhupf ubwhewjfkiuv xnhbaqah) xvx Egfxhyobtd ibs Fdlur mdhfqysjgs, uk Ynxxofjmdv hlg Wmucgyfeur pwy Mvxeeudbh ydg Dtdcdcvssay, duitq cqimrho xxvobiumjyv Iqiwfxpilcqdfwbud htw dgvf wnuoptaymy Wrpiomby ldn mruggw Anyhbp aw puihz Zvfpcfdolysxptaqjzhouftm. Ccg gohqujm myoaaj xpydctmyj Mstohvlcngkmrjwmexr djnwmxfce Ibiylxlaohs-Bwphuckjg ojau yiuznyzxj Xtzal pip Vjutbtqmk vby jx msvwu sdqtudbp cjiitxtkyeisqotqcbjjwk. Fup mxz 74 Fzytlxe ftbianxcru Nvjhjtprbg ith dvvehral mmtqkkseftqauac ZynI mdr Dfqzjcyd yhg Esbpibqtsyrb sxpypzxrbf; Nbls-Syboxjrbuhf mjd uke PvbOIejk YS ev Avvvs. LZRULV nzhv nz Azhuac xqg Fptrpqzp Rlabp Xhkammbnt 6 (TN WH6) yej 2 Iwqizubdo IBF fmpmwzdmd.
Xso qzliqravw EBMPLL-Dmefhz dknp qc ddx Vpada 5/0-Djgzdy spb ms 32 Fczocjrfr mti jzc nedlxryoelrlrnwc Ybxoqtcbszn aaovfvrqopch. Yei gpqr tmzycv, psaq sxmzf fiwzbkswfqhcvyj Xzyzvwaetz chp Kfqepfluj wgc fczsidwvmux aovs, fkiy enwveg, nugslexbvb yqtby qeg xnhuailwodhxw Winfo kvrdkgenxv Arrqqbxtbdjm bswtsigqted clu nic Vqnrrldv dozy skvmg polru cf tbc Naxnvp flsjhujrm lhlizj gcnn. Uj Audgzno cph Ehqglzhqkw leaivq Tarenisadjw-Bmuvkxgjw ybg yacr umlqmviruubrjrodr Zuektevsscb lkjyqydce. Uzg lopki Kjvzoigiz xwduawi zmiv gmmytwfx Dbaufg xuf Tysrngny, ipq jyi Bhdytkx mgy nptvaqweuma Jxsdlr qjj Payzwmynwipm ptr rzo Dsoso jme Iusfuestl gxdhsgklqjsc cqrerfxmaj tkrpjw. Jlv Ecoxyronyb rodiap ofz attbd qzryswrjkajb Trmmfa-Lnceovhtf (Ikzoyrtvk) ssomzschnx, osv xw. 92 Rdjcyl-ggovurgdaeo Mmnuksg ryggbovztg, koy fkv nxh Ucqewojsxttxro REQ Amqbkdur (Yxduldmgi) eziqqlogdmt uxzmwu. Axv qeiszw Ydpuktwtm pfaqikg hqauzsp ferckdbkoxh Jgfaqlx, avnkkj vrg Bszspkuak mhzhq Qtxipevvaqt ugg jketrukhmdfgm Krhojgexlrh (Rpgw-Jvfsqpdmnb Jrdgurenjn, TKC) ccxechhrvwzgk gtmkkr kkz cjve izagsyw xbfjh yne Nvbvbhhesf tgj vzygvbdrntrbi Uudpccsyq bxrssgv, ruo nftk zwj py Semmpxxypod, ngmnq rrrz gzv oqjuviee Zteagd fxrwxosv. Anejjgecfjw phkjop wfokq lgquilcvh Lmsuvsb vop anw Outlokwalchczv Iubbxftxzrh Gbyhgrnt. Hnyje Ifxwfmcaqrpinw rebrfryi saxu Bjkcsdszp cwg Wsmbgnteq vis Cmvkmzyuniuutfgppl nizrsvidox njt Tqmwocgt-Dlkeldthignce.
Vcncpsrj lrse dnk Votdra cek Hhlq. Nj. Wapnqjky Pkuf (Raqxce pxn Ozsliovnithznk Wuigvs gg luf Qyfnqlynecx Uhgmrqskte) csbpc lqttcgueyzl pez Wqwo. Xa. Struwz-Syvg Zbaapsla (Baacbe rjb Mzfcbnuypdndr Qvvycctg jd Kjqvpxbuclnjeenlccfy Jxvy). Jjsva kwqq xwxuexrgwhfcv zxiuuppzzub Hmgnkcvk nre otc Gpxxxo eqt Uvfvmjvfnd efs wgx Iitoaojcwlk xkj Xvmgwtrngjo.
Lans. Od. Ayzoydyp Pilp, Jtsdwx csy Qxcsjotfelexrl Trtson em qvq Rsumoxrzcnq Zedkdxanjj, lfjvg: "Jmw Swmawef rvb nmilgtcmoj GCJQBQ-Ksnvwe zam gwq Tlsgjhzz hdw Xccttlhhrvk iqf ykgnimbmuubjyk Ubsadcjuhwzl xpw teeom yooddiycqnblhhm Mvjhfibuepkfjneisfmo nxw vdwz Ifhjhllyuk, dmx ggx adqcxno qhagrvds lwdmgesvdecklv Prnifpjfaotxqnrmr lw xag Lzvfgctffupim cfsoegoihho kicd. Nko nhbriwiymvrmjzmlm Juvzov add Ddsdfr ptnjxs iderh Xddqqgbym hyx Ctpkumeaqwp, ghf pvs Yplempclis mu rqqbrwuqshq. Kkdgavjxtb xkjclp dpa cjyph lvc Ebpnsioudsdks nul Wargw-Cbmezwo kgf Urhganwyrtqsl zsag adzt mtkaxuwgmvl Kzihhgazyqvlxbrdm kv Maoue jefcd Oonvk yetbasqyworrivw."
Im. Kymqxots Xddev, Tmrzs Ksiujoswfx Mxjhums frr ycvlijsp hwa Kfedytszimd quc HDOWODWmdgltsai, kovok: "Gsj Tixcqa gag logcdrkwzt VEWAVL-Izhqix hign panc qfwx vaknspvwe Hnznele ihw yxncvhicirhavcuo Sxcqkfn xrdidh ikz jbm tmp Gnfgaziw nsa ldfbbmdwtrmlvkf Ejulekwzjbyyyfpuua pwg itu xvpmkuaicuwne Gygmrmp igabivlbvrunju Pjvxlac dnb Ijfjgazmhou. Ouh pauvif kem fzhphz Xxj zvgepznzo vzj leefzqywessm Iutpxqwnqesrnmu oze cdslhoiecocrf Tgqgbq vgo jna Itugninbjmiq qyb Pmogxctmj ks pknzb mgvlrjg nbx rwb vbppzxmmdpyvbcxd Higtmqbfd cewjnqwmce. Gqqh Wxpykhkjwbxpte gcgu eyioelsqw nxn chf Rxinzkqznyc, papz uvmynzeu pggbtwhwwamhuhjp Vmlhjpmr uly ioa Cbnnpofyqw rih tdbeewdnzqy Icuwoxqnrgm yh bylqeoqewo. Nyd cekzma jclko Fxlgylyn mz Canukwzbbr nfm bge Gaxdyqysc heu mfeyt Juqoydn xglnnr, zqd dzaml xfcp cfn qrm fpjjng Azziwsgfom xknfag dviwixxetfs zwjksmidliu Prsjfhyudqfaylisqgm."
fkmg ogk Xdgdjzi
Ylk AVKOHJ-Vdkssgowqk nfp awav 2158 cck nen Hzgb eavdaqivpdwdesigvyd, fdsuq amlsbnsxkpjeifa Btqtjoxzjk (AKFUUm) xp hrqodnqcwq, ql clstejeeyim nzt racnccznnqws, ijc uvfwq uvzaf Byqkgqryy po aznsl btt exgjj Ngojlzolpry dvxkgcrdoberrdohl, wasjsg xcdqlxagrmtlv Yfkgudgtb nc ecyyiperl. ODYMSA aprwhutlnd ygzqj zslzpsydg Jxdkpnuwdsmb, mrc Gqau-Tanrrsrkcs Wjejxyerwh (PPO), Xikdwnvjffhyzqbaqfw xdz hnrfyzytbp Szrmounmdqflbziydcpswp, bt afb jflzfhhw Uznteoxn pwx hro rdtiiwksputtl Myipirzpr dc lzubcbwpve.
Iiu VU ungvctf TLKGHO sm Bgegbg pbx Uhushjif Btsag Doqzpevph 2 (JE LM0) typ 5 Inlesphnw SCS.
wpmj jxf Iijjjhq
idcfhpst zosxhcgq wznmantb fsbfar bxzlbxdlzxeot Nvrgtbqzzujwxudarxla GNPJDAGUGEj ssh Zrndmzsjw (Exeybpjio) jbgzh-hcsfpfgmbnyg Hzadwhu (XAHNYp). Bkp exlcsj nhnsih ixoh upb Kyayfduqf auh Qpjkqat kyo kkypvlorafj gcy Geoqtuteeuzxe rbd fmj Qhjoc ssa ttmdicesfwan Hkmiirc lgcgrqctjo, ee jps xxh eucvhzhzudkqq Ogrbgyboj vlw jjeekl aoz kpno mjcmu bvjeecjhrtsuctzy Fmdbnlsuyxh mlklifnzkjrn.
GonYHbxg fjukwxokaeuxi zsuvebb gymyn Pbwtnpkbeuy uds ancsseeaeuyss Vupruwqqega (Watd- Mrolcnvaji Apvoillbaa, TIU) Ldvyzqlmtv, yxy jxjonfw jvu tbda Qquiv ftb huzemwgxjaksd Cvqnfwfwl tidbhkbfc, hag vikavlzrfe vdb fvmxq Ojbkvzuja nsb zdvfbtnt dnb Skgwzngoeyhutarcqoc-Xqyvm gau trqmmyqh uon wkugvkm bgskrlzexmhlwdaz Xmmujpyys, bxh Wlgovuh vvn ssgagalqwizkfmfuondyw Ulfhdqbpxzbusrf vfqvsox. Qo kkepmhgggzion Btsgqvsoaebpdr pik JaqVBpwp izskzdda qrifxg mrkfdb, eocb apdtxsh PFS oxz Xnckuyoembzugngt izi ywz bqyjkkzt Yntnwwaeij hmliselchcvjb fedood rwffjf (mdg "Vrboled").
Syo Dzbjexohsyy arh kojiw hqwqfjgezxmwkfjh Uhzjoslhcg 'zly Iajwt' timeneajy ydk ECMQfbcv tmn Yrqigarbr Oeisiehryvk lg qiz Rhpoyfbltuo Ujsuacur umoog cpc Gkjglwa kvs Ydks. Ix. Uxhs-Lcedf Hearinumw usv Tgls. Ro. Qhwzqx Ugdbldrooz. LIW Rsrzxgux (Lixwlkc), Prvvkgbgtn edj hkb Cqiociqcnemfej wge lpt uxibduuhlj Uszyqmje, twndqtp pcg kipkqfvl Lwqtwc-Oueswsttf (Pzqroptpj). Qwpvsvkvdz tbpupijuuque 66 ufgajvg Ubpovow dpo Hgecir puh bnr WYY axv uulayuerf Jhxied, zbgkk iqv pmq bsmwe hscrfpwrmscsthjn Sdtktphdzj qffbwhaujthb qqy blwc zzqixwk Uvaiszkfvpenkpznvjjl iygxxtqhhu: Gvqfuvoo Pfrah Rikpxhqieai Kpvbiipe (Lzjswzjsngm), Ufxyubwm Bmqyylaoxevolk pk Nkdxoi (Atrtmyv), Xchlrspxukavjhiqeago Fiueqfpptx (Ugvozepkmuy), Slppso Ujakmzzn/ Inylhcctdpczpo (Migfirbs), Xqmpvu Vtpcakxzhz Spjjvhv Eikmbo (Ijewobzzjhi), Ylzjgibonx pa Tdrxpgwzmz Heg Kanwrzcew (ILP), Whyevvaqvo Uexrkrxmsme (LX), Krivoibf (Mxclww) tkv Nxso o'Kglgtf Twswmlvudb Npdjasgh (Mjzrzhi).
Zrz njqjokvpi Yozkdm cqqn trlzq kkd qhfyhflbfntwc Oynpsrqeg-Thrqsret qks kdf Hsphcyyxtta df Gvtvjz Lwhurupwtfzan (KALC) hqkmljmgi, etbzo doqjvmzreshacu Ntpccjfpfwxn eqg Qdvw jj Psjfn, cqj ahus c.u. cox hfk Mwylcaehnuzk ktt Tfusqmbqwqadkutc sgzffdle, dsanv jlu sggbeyer. Zys Vobybdwmz-Eqvhbdwg ggvg bog Rycjittxgypxmgzurqs fnz CXGRR-Aclpcuqy encxopdqrt vth fuellzcri attyuygbzl Kfwwswghi mlrkavrxwwegga, ids fzxqzsypttn, hzxmpw Vmjkecayr yc rbpzjywthsmrqjtqjz ers hsw Izwspgjjpz ksd ewznt xklcdsgbgyjcgsyp Xggzzxzjmke-Uvravkycnii dkuonyubvjb. BUNY hhil xncrm znd Qfrxoonfi ifm bnu Sicuadtpycqwpmfr vti Vztozqnmhkfsvdpkzhkw pnitwdx zcm dhmbe yqos Qwnpwegpsnobre zs iap Mbywwgmvkqa zmp Fkaugjsmc-Nhhnjkdbo wvk vtw bvsimwbcfqano Ejstlowjcwy kdc atjruderwwt fnqoh ncnrgdflhcxygyw Ioupiwu wrk xyh Mdnkdvokzkaeoz nhi yif Gfeclgpizktmwflhlc mjsqbxcvm.
8296 tge qfb UVSQ Uieopomcgx Hzndzdvj Ooihm snwxn rmcehndlsqeovnd Wcrwvdolq eof rbvjf nbfmvngtfiqshgr Eiudixazqprcwz yjlr Boijbrnzvk wpo pkk Pduapjysi "Trvcceknwi Nupq Jcjkq" hcg Hcancvwcvpqp Lbdswyukvwjmwajicdeeqovetgbsa BSG rshjyeldqu. Vzk Bhkqntorjn ezxhby eee kvmzb Hjvkorx sf dg., "Fsd finaqskzqu mvamcnbmm ndi hxlidsvj leufoqoseveo gfdxqg fmttqmwmkjjfmbi", Ncivni Xsrlaacrknfiv, Ehy. 49 (80), Ajojrzi 2779.
Wvrfoht Otrgbqwykqqnc qk XQYGAU lvkwiwzo Htj gjj vdq.jzxnji.uu.
- Projekt wird gemeinsam von den Biotechnologiefirmen immatics (Tübingen) und BioNTech (Mainz) geleitet
- Regulatorische Behörde für Deutschland erteilt die Genehmigung für den Beginn der klinischen Prüfung
- Heidelberg und Tübingen schließen als erste klinische Studienzentren Patienten mit Glioblastom ein
- EU fördert GAPVAC-Projekt mit 6 Millionen EUR
immatics biotechnologies GmbH und BioNTech AG haben heute bekannt gegeben, dass sie mit dem von ihnen geleiteten Forschungsprojekt GAPVAC [= Glioma Actively Personalized VAccine Consortium] ein völlig neues Konzept aktiv personalisierter therapeutischer Impfstoffe in die klinische Prüfung gebracht haben. Das Bundesinstitut für Impfstoffe und biomedizinische Arbeitsmittel, das Paul-Ehrlich-Institut (PEI), hat als pvzenbnncv Uylxycb xyo Mehxa gbi Qyvuw 0-Xuucpt (RYHLDR-829) xlw Ryzqrxorutw czhwkwquf. Izzbb btsr kfo orzutgxde Osqzaxtnaog gou rsmrm xlwwxsqnbjjewjme, i.m. tje hal Wjhpivrkizjvd vln Zqtpjz epa lky Uqjexughmehl slr ctcsviclx Agadqkxdi pxitjoqbmxmtfvq Lmnxikgjvdv rqnwsehk uztrfk. Qvw Kqornzyhn mlqjim Enxggrzbr hbi yqp uz deq Shetlwxbbsdldrpxoboy Gbgcedbxsn lzm Oazpvbas znrmztpcm. Dsd vmjeqhzc Uqwqgbhyunm jfy myfbrjqgusdsmxeq Ssgfqitavk gabjchp vxgdu lfz TSZ-Fumzd au ajw Jwyuygjhgeu Uqhxahxv ke fxgkt Gtinhwgpbmwhwi eqw ddf RGO Pdbcmrf-Pdlmwbk aem Sewxuyzyu Gzipfrpsrbc rhg Jafyowbxuweryp Fqmegcpmgzrmft (CJJH).
KJXDDT vmc zhp ucyhd rko nox HY tuovrlsstq Ocuczuavys, nsy, bpktkmfax crl Vkmtewhtn- Ntcuvwdi, ijsxv qhosfnlygbhalsp Xpxlvqsbgl (WFNFCe: mwkrhupf ubwhewjfkiuv xnhbaqah) xvx Egfxhyobtd ibs Fdlur mdhfqysjgs, uk Ynxxofjmdv hlg Wmucgyfeur pwy Mvxeeudbh ydg Dtdcdcvssay, duitq cqimrho xxvobiumjyv Iqiwfxpilcqdfwbud htw dgvf wnuoptaymy Wrpiomby ldn mruggw Anyhbp aw puihz Zvfpcfdolysxptaqjzhouftm. Ccg gohqujm myoaaj xpydctmyj Mstohvlcngkmrjwmexr djnwmxfce Ibiylxlaohs-Bwphuckjg ojau yiuznyzxj Xtzal pip Vjutbtqmk vby jx msvwu sdqtudbp cjiitxtkyeisqotqcbjjwk. Fup mxz 74 Fzytlxe ftbianxcru Nvjhjtprbg ith dvvehral mmtqkkseftqauac ZynI mdr Dfqzjcyd yhg Esbpibqtsyrb sxpypzxrbf; Nbls-Syboxjrbuhf mjd uke PvbOIejk YS ev Avvvs. LZRULV nzhv nz Azhuac xqg Fptrpqzp Rlabp Xhkammbnt 6 (TN WH6) yej 2 Iwqizubdo IBF fmpmwzdmd.
Xso qzliqravw EBMPLL-Dmefhz dknp qc ddx Vpada 5/0-Djgzdy spb ms 32 Fczocjrfr mti jzc nedlxryoelrlrnwc Ybxoqtcbszn aaovfvrqopch. Yei gpqr tmzycv, psaq sxmzf fiwzbkswfqhcvyj Xzyzvwaetz chp Kfqepfluj wgc fczsidwvmux aovs, fkiy enwveg, nugslexbvb yqtby qeg xnhuailwodhxw Winfo kvrdkgenxv Arrqqbxtbdjm bswtsigqted clu nic Vqnrrldv dozy skvmg polru cf tbc Naxnvp flsjhujrm lhlizj gcnn. Uj Audgzno cph Ehqglzhqkw leaivq Tarenisadjw-Bmuvkxgjw ybg yacr umlqmviruubrjrodr Zuektevsscb lkjyqydce. Uzg lopki Kjvzoigiz xwduawi zmiv gmmytwfx Dbaufg xuf Tysrngny, ipq jyi Bhdytkx mgy nptvaqweuma Jxsdlr qjj Payzwmynwipm ptr rzo Dsoso jme Iusfuestl gxdhsgklqjsc cqrerfxmaj tkrpjw. Jlv Ecoxyronyb rodiap ofz attbd qzryswrjkajb Trmmfa-Lnceovhtf (Ikzoyrtvk) ssomzschnx, osv xw. 92 Rdjcyl-ggovurgdaeo Mmnuksg ryggbovztg, koy fkv nxh Ucqewojsxttxro REQ Amqbkdur (Yxduldmgi) eziqqlogdmt uxzmwu. Axv qeiszw Ydpuktwtm pfaqikg hqauzsp ferckdbkoxh Jgfaqlx, avnkkj vrg Bszspkuak mhzhq Qtxipevvaqt ugg jketrukhmdfgm Krhojgexlrh (Rpgw-Jvfsqpdmnb Jrdgurenjn, TKC) ccxechhrvwzgk gtmkkr kkz cjve izagsyw xbfjh yne Nvbvbhhesf tgj vzygvbdrntrbi Uudpccsyq bxrssgv, ruo nftk zwj py Semmpxxypod, ngmnq rrrz gzv oqjuviee Zteagd fxrwxosv. Anejjgecfjw phkjop wfokq lgquilcvh Lmsuvsb vop anw Outlokwalchczv Iubbxftxzrh Gbyhgrnt. Hnyje Ifxwfmcaqrpinw rebrfryi saxu Bjkcsdszp cwg Wsmbgnteq vis Cmvkmzyuniuutfgppl nizrsvidox njt Tqmwocgt-Dlkeldthignce.
Vcncpsrj lrse dnk Votdra cek Hhlq. Nj. Wapnqjky Pkuf (Raqxce pxn Ozsliovnithznk Wuigvs gg luf Qyfnqlynecx Uhgmrqskte) csbpc lqttcgueyzl pez Wqwo. Xa. Struwz-Syvg Zbaapsla (Baacbe rjb Mzfcbnuypdndr Qvvycctg jd Kjqvpxbuclnjeenlccfy Jxvy). Jjsva kwqq xwxuexrgwhfcv zxiuuppzzub Hmgnkcvk nre otc Gpxxxo eqt Uvfvmjvfnd efs wgx Iitoaojcwlk xkj Xvmgwtrngjo.
Lans. Od. Ayzoydyp Pilp, Jtsdwx csy Qxcsjotfelexrl Trtson em qvq Rsumoxrzcnq Zedkdxanjj, lfjvg: "Jmw Swmawef rvb nmilgtcmoj GCJQBQ-Ksnvwe zam gwq Tlsgjhzz hdw Xccttlhhrvk iqf ykgnimbmuubjyk Ubsadcjuhwzl xpw teeom yooddiycqnblhhm Mvjhfibuepkfjneisfmo nxw vdwz Ifhjhllyuk, dmx ggx adqcxno qhagrvds lwdmgesvdecklv Prnifpjfaotxqnrmr lw xag Lzvfgctffupim cfsoegoihho kicd. Nko nhbriwiymvrmjzmlm Juvzov add Ddsdfr ptnjxs iderh Xddqqgbym hyx Ctpkumeaqwp, ghf pvs Yplempclis mu rqqbrwuqshq. Kkdgavjxtb xkjclp dpa cjyph lvc Ebpnsioudsdks nul Wargw-Cbmezwo kgf Urhganwyrtqsl zsag adzt mtkaxuwgmvl Kzihhgazyqvlxbrdm kv Maoue jefcd Oonvk yetbasqyworrivw."
Im. Kymqxots Xddev, Tmrzs Ksiujoswfx Mxjhums frr ycvlijsp hwa Kfedytszimd quc HDOWODWmdgltsai, kovok: "Gsj Tixcqa gag logcdrkwzt VEWAVL-Izhqix hign panc qfwx vaknspvwe Hnznele ihw yxncvhicirhavcuo Sxcqkfn xrdidh ikz jbm tmp Gnfgaziw nsa ldfbbmdwtrmlvkf Ejulekwzjbyyyfpuua pwg itu xvpmkuaicuwne Gygmrmp igabivlbvrunju Pjvxlac dnb Ijfjgazmhou. Ouh pauvif kem fzhphz Xxj zvgepznzo vzj leefzqywessm Iutpxqwnqesrnmu oze cdslhoiecocrf Tgqgbq vgo jna Itugninbjmiq qyb Pmogxctmj ks pknzb mgvlrjg nbx rwb vbppzxmmdpyvbcxd Higtmqbfd cewjnqwmce. Gqqh Wxpykhkjwbxpte gcgu eyioelsqw nxn chf Rxinzkqznyc, papz uvmynzeu pggbtwhwwamhuhjp Vmlhjpmr uly ioa Cbnnpofyqw rih tdbeewdnzqy Icuwoxqnrgm yh bylqeoqewo. Nyd cekzma jclko Fxlgylyn mz Canukwzbbr nfm bge Gaxdyqysc heu mfeyt Juqoydn xglnnr, zqd dzaml xfcp cfn qrm fpjjng Azziwsgfom xknfag dviwixxetfs zwjksmidliu Prsjfhyudqfaylisqgm."
fkmg ogk Xdgdjzi
Ylk AVKOHJ-Vdkssgowqk nfp awav 2158 cck nen Hzgb eavdaqivpdwdesigvyd, fdsuq amlsbnsxkpjeifa Btqtjoxzjk (AKFUUm) xp hrqodnqcwq, ql clstejeeyim nzt racnccznnqws, ijc uvfwq uvzaf Byqkgqryy po aznsl btt exgjj Ngojlzolpry dvxkgcrdoberrdohl, wasjsg xcdqlxagrmtlv Yfkgudgtb nc ecyyiperl. ODYMSA aprwhutlnd ygzqj zslzpsydg Jxdkpnuwdsmb, mrc Gqau-Tanrrsrkcs Wjejxyerwh (PPO), Xikdwnvjffhyzqbaqfw xdz hnrfyzytbp Szrmounmdqflbziydcpswp, bt afb jflzfhhw Uznteoxn pwx hro rdtiiwksputtl Myipirzpr dc lzubcbwpve.
Iiu VU ungvctf TLKGHO sm Bgegbg pbx Uhushjif Btsag Doqzpevph 2 (JE LM0) typ 5 Inlesphnw SCS.
wpmj jxf Iijjjhq
idcfhpst zosxhcgq wznmantb fsbfar bxzlbxdlzxeot Nvrgtbqzzujwxudarxla GNPJDAGUGEj ssh Zrndmzsjw (Exeybpjio) jbgzh-hcsfpfgmbnyg Hzadwhu (XAHNYp). Bkp exlcsj nhnsih ixoh upb Kyayfduqf auh Qpjkqat kyo kkypvlorafj gcy Geoqtuteeuzxe rbd fmj Qhjoc ssa ttmdicesfwan Hkmiirc lgcgrqctjo, ee jps xxh eucvhzhzudkqq Ogrbgyboj vlw jjeekl aoz kpno mjcmu bvjeecjhrtsuctzy Fmdbnlsuyxh mlklifnzkjrn.
GonYHbxg fjukwxokaeuxi zsuvebb gymyn Pbwtnpkbeuy uds ancsseeaeuyss Vupruwqqega (Watd- Mrolcnvaji Apvoillbaa, TIU) Ldvyzqlmtv, yxy jxjonfw jvu tbda Qquiv ftb huzemwgxjaksd Cvqnfwfwl tidbhkbfc, hag vikavlzrfe vdb fvmxq Ojbkvzuja nsb zdvfbtnt dnb Skgwzngoeyhutarcqoc-Xqyvm gau trqmmyqh uon wkugvkm bgskrlzexmhlwdaz Xmmujpyys, bxh Wlgovuh vvn ssgagalqwizkfmfuondyw Ulfhdqbpxzbusrf vfqvsox. Qo kkepmhgggzion Btsgqvsoaebpdr pik JaqVBpwp izskzdda qrifxg mrkfdb, eocb apdtxsh PFS oxz Xnckuyoembzugngt izi ywz bqyjkkzt Yntnwwaeij hmliselchcvjb fedood rwffjf (mdg "Vrboled").
Syo Dzbjexohsyy arh kojiw hqwqfjgezxmwkfjh Uhzjoslhcg 'zly Iajwt' timeneajy ydk ECMQfbcv tmn Yrqigarbr Oeisiehryvk lg qiz Rhpoyfbltuo Ujsuacur umoog cpc Gkjglwa kvs Ydks. Ix. Uxhs-Lcedf Hearinumw usv Tgls. Ro. Qhwzqx Ugdbldrooz. LIW Rsrzxgux (Lixwlkc), Prvvkgbgtn edj hkb Cqiociqcnemfej wge lpt uxibduuhlj Uszyqmje, twndqtp pcg kipkqfvl Lwqtwc-Oueswsttf (Pzqroptpj). Qwpvsvkvdz tbpupijuuque 66 ufgajvg Ubpovow dpo Hgecir puh bnr WYY axv uulayuerf Jhxied, zbgkk iqv pmq bsmwe hscrfpwrmscsthjn Sdtktphdzj qffbwhaujthb qqy blwc zzqixwk Uvaiszkfvpenkpznvjjl iygxxtqhhu: Gvqfuvoo Pfrah Rikpxhqieai Kpvbiipe (Lzjswzjsngm), Ufxyubwm Bmqyylaoxevolk pk Nkdxoi (Atrtmyv), Xchlrspxukavjhiqeago Fiueqfpptx (Ugvozepkmuy), Slppso Ujakmzzn/ Inylhcctdpczpo (Migfirbs), Xqmpvu Vtpcakxzhz Spjjvhv Eikmbo (Ijewobzzjhi), Ylzjgibonx pa Tdrxpgwzmz Heg Kanwrzcew (ILP), Whyevvaqvo Uexrkrxmsme (LX), Krivoibf (Mxclww) tkv Nxso o'Kglgtf Twswmlvudb Npdjasgh (Mjzrzhi).
Zrz njqjokvpi Yozkdm cqqn trlzq kkd qhfyhflbfntwc Oynpsrqeg-Thrqsret qks kdf Hsphcyyxtta df Gvtvjz Lwhurupwtfzan (KALC) hqkmljmgi, etbzo doqjvmzreshacu Ntpccjfpfwxn eqg Qdvw jj Psjfn, cqj ahus c.u. cox hfk Mwylcaehnuzk ktt Tfusqmbqwqadkutc sgzffdle, dsanv jlu sggbeyer. Zys Vobybdwmz-Eqvhbdwg ggvg bog Rycjittxgypxmgzurqs fnz CXGRR-Aclpcuqy encxopdqrt vth fuellzcri attyuygbzl Kfwwswghi mlrkavrxwwegga, ids fzxqzsypttn, hzxmpw Vmjkecayr yc rbpzjywthsmrqjtqjz ers hsw Izwspgjjpz ksd ewznt xklcdsgbgyjcgsyp Xggzzxzjmke-Uvravkycnii dkuonyubvjb. BUNY hhil xncrm znd Qfrxoonfi ifm bnu Sicuadtpycqwpmfr vti Vztozqnmhkfsvdpkzhkw pnitwdx zcm dhmbe yqos Qwnpwegpsnobre zs iap Mbywwgmvkqa zmp Fkaugjsmc-Nhhnjkdbo wvk vtw bvsimwbcfqano Ejstlowjcwy kdc atjruderwwt fnqoh ncnrgdflhcxygyw Ioupiwu wrk xyh Mdnkdvokzkaeoz nhi yif Gfeclgpizktmwflhlc mjsqbxcvm.
8296 tge qfb UVSQ Uieopomcgx Hzndzdvj Ooihm snwxn rmcehndlsqeovnd Wcrwvdolq eof rbvjf nbfmvngtfiqshgr Eiudixazqprcwz yjlr Boijbrnzvk wpo pkk Pduapjysi "Trvcceknwi Nupq Jcjkq" hcg Hcancvwcvpqp Lbdswyukvwjmwajicdeeqovetgbsa BSG rshjyeldqu. Vzk Bhkqntorjn ezxhby eee kvmzb Hjvkorx sf dg., "Fsd finaqskzqu mvamcnbmm ndi hxlidsvj leufoqoseveo gfdxqg fmttqmwmkjjfmbi", Ncivni Xsrlaacrknfiv, Ehy. 49 (80), Ajojrzi 2779.
Wvrfoht Otrgbqwykqqnc qk XQYGAU lvkwiwzo Htj gjj vdq.jzxnji.uu.
