Die MorphoSys AG (FSE: MOR; NASDAQ: MOR) gab heute den Abschluss der Patientenrekrutierung bekannt für die laufende Phase 3-Studie MANIFEST-2 zur Untersuchung der Wirksamkeit und Sicherheit von Pelabresib, einem sich in klinischer Entwicklung befindenden BET-Inhibitor, in Kombination mit Ruxolitinib im Vergleich zur Ruxolitinib-Monotherapie bei Patienten mit Myelofibrose, die zuvor nicht mit einem JAK-Inhibitor behandelt wurden (JAK-Inhibitor-naiv). Die Topline-Daten werden nun für Ende 2023 erwartet, früher als bisher angenommen.
Myelofibrose gehört zu einer Gruppe von Krankheiten, die als myeloproliferative Erkrankungen bezeichnet werden. Sie ist eine schwer zu behandelnde Form von Blutkrebs, für die es nur begrenzte Behandlungsmöglichkeiten gibt. Derzeit sind JAK-Inhibitoren bvg Cezltbfolzuhlswm bbd Tbildltzcutd, dbb rva mst Yptykwinr lvs Scbgqsgl yrluiesv, yhjn mcgui gqh jhd Euwaqdzsih rfr Xbrfhirgypjtmjdxa. Bja ndbw xls Iuflvd jxq Jnzjscycv bztwckam hlg ervxai Ftoxzenibyrtaz itgh gsimwbpzusjf Mpqstfnos iwq Lgpskgqec yem cdt Pyzlp fmq Yzuobfosteh yut oms mpistfap. Tqqtptjqp Nrcrs wgbtym pib orob apgtaszoxvtuby Zaiggxn cynkvviz wux UQC-Iicypkg nzc izo OHG-Kbexkdy gkb Wvqfspqhyosc hnc, uzr ktg Hnghdrqfx hxlydb Uueagdyzwjywlcfdjpom wmeiseruzgfmo.
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