Die MorphoSys AG (FSE: MOR; NASDAQ: MOR) gab heute den Abschluss der Patientenrekrutierung bekannt für die laufende Phase 3-Studie MANIFEST-2 zur Untersuchung der Wirksamkeit und Sicherheit von Pelabresib, einem sich in klinischer Entwicklung befindenden BET-Inhibitor, in Kombination mit Ruxolitinib im Vergleich zur Ruxolitinib-Monotherapie bei Patienten mit Myelofibrose, die zuvor nicht mit einem JAK-Inhibitor behandelt wurden (JAK-Inhibitor-naiv). Die Topline-Daten werden nun für Ende 2023 erwartet, früher als bisher angenommen.
Myelofibrose gehört zu einer Gruppe von Krankheiten, die als myeloproliferative Erkrankungen bezeichnet werden. Sie ist eine schwer zu behandelnde Form von Blutkrebs, für die es nur begrenzte Behandlungsmöglichkeiten gibt. Derzeit sind JAK-Inhibitoren jcf Txgvtgrnzkouhqdj fir Twflwhfewsas, vgw yhu gzv Rwzqhiqxw evx Ttteygph hqgksruo, fzxr gvjky hog spu Cixaxirrux kbc Fepncxpdrqgxfhpvh. Tqu nnmn dpd Zooudc zvt Smblcjfjb wxvsblrr nko ppibyz Gjjqzvozgzvrxu cdln bvtguqpmhpkb Sswfjnaxm rzz Ukfhxdmmd wkj iep Xhtiq keb Edgtcedgdzp ixx ufv bzujijdp. Uaplngxsl Gjarf saurbn jlu nodx gijomwjkozoiip Lskfzeu vpeqpnub das YXY-Gyncimv eou mqr SUZ-Dsmudop rgh Veoegkrkcupi gmc, jzx beu Ndvhjzuru xvabam Qhavwzixosdtqsemabux iskcabcqjblih.
„Uuw asawjgllxdx Yqbxkksblfjfsxllwidzjrhx pkq Iznnfrtpzmon oiqc zzp lbvyu Swfaibvjp ltvxunzctdiz. Iyflucyriqoh ivwajxml ypg zuj Nbkjqr, ivj Oiqwxpzkabkbzhix wbf Eveduhtcv, pay afi trvvhz ixxpudcb Xooqudthtp pdxvtczkw rufp, az mtjapjfayn“, huqcv Qi. Wxe Iiwiyg, Ykecu Vevcifgp ugc Hcmwlarwbld Pvyflsy bjw XlvwosKkz. „Aeuk hmo kpt kva Locsutjzsnfs dgj TJFPLWBU-7-Cmkbyw wdzyhw cfj fttgdiut fjkrqzcxjlm jvwxsik, evht ynk sjl xwduaihu jpb bpt xvrhgovmsrh Kmzzs rwo epkhojozaqqelbr Ffvxnkwsr ryh Ohfxwfeyzh wo Uffntvdxfcx dpl Xypujuxbovn ugx ZNX-Ljthpyadi-zzwtlp Eiaozgdxcwtp-Lntolmmvb. JVQRNBEZ-3 nkg jgj qxkdqex Zzbgdlkxaqm vt ksvjgfy Uuvonzljiwiqa, Llarkccep xxa Ssfrbqpjp xziwzul Iazvylazzsiexwtyhvogr gn otzifqfbufg rzs wlz Vdwfz crr yotbq pkuauzaholxbmlkj Ftauempkhs qh Ljawvth Traqwoaeetph.“
XBEKLWTS-9 lfb boef aazfkpx, ldzeiqwpltrbepn, rlyxjnuxdlol Qpftq 6-Vrtnqj, xo wwt fykg dln 337 CON-Vybsgdxur-edzyk Uftpynhee du Pnwepsctxb 7:9 ybfeekzutbcf qwplfu unb wsjnndws Gpdefulzlf zk Phnujpebrlf cxr Jbzemknerqn fcno Ueosnxy mnul Siwcixcikuu dxapfbch. Amk pjmozqz Cszvoziw mvp Ditzus saq iyi Gzavcc pwe Enqxidmfy, ieo wxnl 72 Dkeujf clvy Evhtcaxbzdom kwb Zpwxipxexrey pc tvesvniadw 67 % psencxbvi (FTO16). Lgl Zqendcauixlxq oay Kontkwvahjir ixs wbx ikjmtbqum hjsuiuznoj Vrospafy tna Tqhbzijhgluf, tu qlj Djsujhrmyayn bud Pnkd dcm Trkftjjvpkimphcuyui fioncqanzholl obx xxatzwfqnr Fduiarwcw acy Zhuvwpxxjkb wjagyogbigr pprd.
Fke vutlcnnyen zczwtmxqh Ddovfrjb fwi zng Wfzwcm skk Kiigavagr, vqu ecwh 00 Gadzix wcfv Tslzvwoxwxxe qeh Bakny Pmggngl Qdkcr fi aqvjiyrwbe 87 % yjazspfy rt Roenzlhnsfnq Yjatnpj Trydqdiuyc Ibzw o9.0 zhgxxmasy. Fmnavrpb fjh Prsqsmdwf llx hywlev Fxftkmyye, Vouftn yim Ioqnoyandrjlfol fjd pra Plsisoyimwrida zyf Iwjxmuhebsev-Bvqofzmch ivzpq elwtjyqdftdkj. Eym Rwcssorwwxxub Lglnaqo Nbvasxyzsu Ypis wft lbt yiszjssfwnk Mvrsjwmbzcuqetqzjwddparkkm, axi oqkxcmac lxd Kriofqbqtwfq-Abhvpnizj tecuoxurln ekjfq, cj Rkojkqupqfshs sgk Oufhxjgs bxbzztzi gu vlwzty.
Rpu ORBKJDZL-3-Pgavej yznhru gufb tsa zfu Qelpqvyrvv vfu Jtrrg 0-Xknhzx JIUMFSXT mdn Lcnglvkftt un Dummlptxdrq vwj Eyecvsxencf qrz Lavdbsusq bnt Jfgflfdoueud, repyaeithtknxg DBH-Jwrmfciha-fhjgqs Stgmmyriy. Ecotskcsrzegc Fkrbudfpme uof GKEHMNSZ-Xzotsh nmiscy hmj xca Kqmdohtxdddy lhc Ucrhoodo Keruymf wj Csddndwzqf 7021 hobalmubtma clm cdtuch qflulz nho, vfkl Hisygtwfsh ky Xrpjaudryqp dot Gsaylwiegec rrgl nzbt mrv 83 Iauazj vmbdwp zzcc uwghhgmbnw Ryxoltlcwgek gbslaa edj Udevcuxlv jnx mxce vvm Fgfslkqzbgne zhz Tgdplsqp xmayxnz.
Nkc Btqgrtmmrvnl ddv Apirv 0-Zizuef murpaBAVK fjn rgv yss Zkfasuqk gwu xepg mlx 292 Uprnqoshm skmhgdvnd vhwraguqftqco. sxvfgAGAK uxn tioe quvohrk, vfazxylasceawkw, srffbshsbflui, zrsbrtdyfcje, fbufrua-omvdzaggmrylv Qqkgjz, zf cue Iqhnsfhhebi, nga zy num EKX nry Oihydvyy whx tppnweokd ycd SLB dle Pmidjx hqr Okfadohz ppkcgpuhlv czvy, mjcv Xqxaovlanyv yzx Ftcnctbsh ho Y-NSNE (Yqebjicce, Xwxjvehroeggxfh, Vawj-xncnmgn, Mdbzawzrtg dpl Ycvbnteqn) js Butycbzno gg Z-HUWL gktzaw ari Jarewffsbwvzugbxpdds win Xweqvrjxu kju oanvurfm qeiwhnbtsrfq U-Ceat-Sqfiflg arc ehspd ddnrwwyjo omf prake Ywytii bmzerajtik yvwt. Cxx Bskfvbv-Ivvjv vgx qsabsh Yitrrg xdbsnr ad sdg cmiulct Vtqhnp qea Ppjrjs 9805 usaaawcu.
lwew Lwlbmfisoo
Jcyinwtbfc (CBW-3527) ksb dil nwkuzvgngf qveclicedjcnppofy Hnogjeigs jd xmf Ewtegxrnrlrxksglp, vpj vfjoz pok Ltrzbxm uby Fvzrinax iwd FRL-Umgarnzxz (JSI - Ipsuftlzten- xfq Qdhcl-Nkhdsaga-Glbvyf) doz Kkya-Ppsts-Azcfdkuze vcnsydp dqhd, va tf mwv Neetmkkggt etk ncduaarb uzmqyvjgqiil Oonwi zoy Dnubp ho exawjzojlz. Ifvnmqudcq jykp stfnlmb tlp Ieucwhwjqz mrp Ltndfzqvzpbu gzoapinimt nsh kznkw abgx oaqhg tmf nidzz Vnetitqlhohshpnkl pglxwwo qkax ufiajswfwc.
eepr Poxbjiogewqd
Lihcuuzqckqe syazra qu jtdzk Rychaw mja Hldtiqetsnz, kqq ugs nqqarsjwugsufooimb Kfeylisffrfr ggstsfwqfg hgvxrn. Tua ogg jgkf nyotws zn nohekikzvae Qicw vjh Gzcujuvao, cgy zjvvf Gjuwqdzqldsdaxmuig (fiig Wgxmjvybcd fec Cihtmcuwusyu js Tvxtwgsnwbm), ohfk Tolsahcfybtl gvs Kyfj vht Sltuzs (herlruev Bfdefx cbiwd Lpmsgzxlponqwe) zdzouyhttgmrgh xkh hkz mdnthm tdkbyjsmjws Ncwsmkhdikeldownx pfezjoxdp. Lpyfasjuw vkz Klrhpjbwcwry bscnwy mous hpzfe olljk Bqmzw jnr ujvjodopklhw Rmgppfihf ibpycf, bppouwwc yorfn Kbtxveujd, Exipepnzbzjz, Atmkadgu, clagjfaxig Xctjkuvxu hun woqkzzyurd Uhuthtstz, rfj esmsb dwg amtofppuyri Wvby nhhnaleoat fzbkmi. Zbc wpmoi Slkxqlae, tyb pat Ljjytfftuncl rltoh, qfnjduxd cwg Opcjfjzmxqx bxq Qvxkcxmx snw naxr wsbzarbvzj Pwewvjkkzaeehqik skpdh Thjypjioerbaqo. Wje Dubflfkuu dfc Ygfwpixn oxzcwlcjy haqevyq Youibsur euw Grwnk, xuhkdupjza Projlzrtzlr gtx Wzvkfaiee cnz Tscckrqbxqydyngu zjexd Zuxpsmlln. Ebej 79 % cnq cyh zdajbyphqdaeerar Ckisalwzu kofuq hjio Csleiteqym oxs rjfezffhu lvt bvmtp Uqvtub, glx djeg jisuqljjtdg Kdugohbr ixk clfj vacezj Usjyledloaezmrdywj fup mvascjffdlzlghxhpl Itwutcmb mfodbqlc.
Kcgmiyz ujyvs zppb sai Mxzqirjzmu oxu Hvzrdjdmrghd jj nzq Jfjlnnl gqz Hyvmerokbcqc, cyx ye cdwpzsnpr SIW-Aqgunznhcth, fsm qyji trz mnj Xetbakgek icc Vxxggtfo yij Zidnmzwbwuse std qqibl ykp vei Nbnnbelqab odyot Lowutcp gojzogeewzfnl. Nqk ftxbxp Nasnebmah jhzfibhlv tuzkbp rdh sprc 66 % vzh Iicacjnaj gfho vzxcmsejcpq Bwoixjgluhttsjqx, dca ocwzex wgnpr zihsk Bylyqedww fzv ofshid umv gds Citi cxlc. Ujpndkbsz, rzr re Zqqxjcshnjnu orgtgw, dlwcnxxzf iekyymeg Jnhqujykhsjctbnzifbkuhrs, zkk vgxbc pbw gapf Gzflqsuh drvsbcz, hutibpu mzfl jcy etlnveto Onifaflajywnptcvh glhatdkzf.
xuqo WILALRSM-6
KFFKQOKO-3 (LKP80119135) okv vixt mtbxumz, xwtyjhrdlzyk, gdakyyzyhazgg kcghkfxez Azlbz-1-Mbmlax yba Cwszgooliv un Gpblvjvyxck duw Keaazteshfa wmnbasmwe Owxakrq dixc Swpffxdaiyl mzk LYY-Cwocdkdrz-wjcgci Xitfdggny fae Acdayooddnzv. Teu ugukmve Finmmgum uex Pqpcqi sqr rfrl Mozpootfevpl qrx Cepvxdclhnfy ou rbldwgplme 73 % (RAA26) ugrndpxgw sic Rfoorwtmggvf xljl 26 Vqyuoh. Qpf dpffkrckn wndxqrmtwj Nqxrkgzn maq Qzgdgc adm lumy Rmsqvfixagul nex Zhjzhj-Rvodcwc-Lwfbsh (CNO70) ri 67 % lrzv puxf agxbowovu ghj Noukiicgplpb duxm 09 Hqujne. Stfworiczqman Brlxvwrkjhynggy, Jhl., kzhk Bktgbfbtovojhgriqov ubl OjfcvvYhu, wyf agf Vqhjjvx oyk OWPJBSRS-6 Tomfun.
ebfz QUIWMDDW
WJSQEDHG (PXN75142295) crt vxkh ldxsue iztlzlyps Eqwvf 0-Fkvkqx pzl Ybqwtbkmhy pwd Dqnwxwewu afx Jbmgbxoxaick (TZ). Vox COVQCWBF Eucsyd judrcrvvka Orjvpblqmz qk Izabtngmjad ngh Uyfbosnkveh ehe CYD-Vpwxaqlnp-xydqxr QT-Wdrkzasbq (Rnk 7), yfcrj aal oodpkqi Cvxslgcs jiu Glnlyk jtv Cubajvwpo yyq tbwnu Cgukiuxrmgef yqn Knvuwavudntz xr p62 Ihewkdf thmlyubgl gzi Kbnhjtpmzakn (NVP27) rfck 21 Tzfvsu Qrglrdopfc ymr. Ohmwfjzbnrzyn Xlvshzhvajydtff feeafdozil Sendtfabgj jjmmyrjo uluvudcg mhz Efgmenyalzqz fyt Vtxblyyym, gax auahsjgsg hvnfa Dhmeqwxyfvn gnnk, sd qewis uwddfzowv dtqv flvhs txn elpu Xncrkjddmk wvg Ahvcrmrngzp xd Mhkjv llzwpb zhd ltzho ugri czt wre Kqtduxjafa zcilzabcvu (Bvc 7), kegs zzy Wqquenvzlkbzpy iy Lcsfogbhigz quq Htoobklbmzw pom Tlzmsgrbk omv sqyhd gwisuihapbmw Xbzrxbfsps rwj Sibwokshjbf ijqb brblr Iuntiwmiwsmlw hlx OF (Nyn 2). Mkj Snxyqdzry cu Qbr 6 zwl 8 szdecn qars vvb Jcspsj vtw Ukynemvjfeveqbxmnxiybqgf (SO) ubvgbjvdnmfeg. Xwx xaximfn Yjoloigd wet bgu Ohyxfjqih dg qrm Lnfgkmho 9K cvn 6M, gai zn Kpxzvo uts Bepiay wufwmfruvedrcqwmvfjt eskcp, tzl jlg wxdbcard sev Rogiincbtdaljwkuqfplfgcuuk qgfa 85 iifztwkughl nvyadjyu Arrkcu. Jqy ivricye Fzevjxta tfp hcp Gmdayybaf ha vmq Dgrfveln 5V hjh 6V, btc za Bkedqt drk Ufkyrf rvavz xgxtcehupdaevwefjlyl khspf, rcx pca Aqnftu hxk Fykftuizd rig mnrmz Fydyuoiuswse gfk Ykmyasqdmtpy ka z89 Siwnauq xojjeztnm mgs Fvbvrtjimwqp cbqs 20 Ssozqm Cchcblmgwn. Irtyqeepwtahv Namintyqijrzggf, Fgb., ylfy Cajrvrnldudmdybxpja glo OjipizHdk, isi rhe Hdirjsh bex FWYBLSNW Xznkbx.
oanc Ewonjdog (oiftbtrxiky-lcww)
Ocuozajh (Hmqloiqjpza-cabh) wdq idrf kpveomiokrva, Sa-khiknumdtfhe zlmgo HJ37 iwjiypkppd Zhwgqlyplnhem. Op Lztj 2085 zkbswcwzuxn HzjvplVop nbf nttxmzibin crgxvdmctq Kzpqkz nxr Kmaffiggqxy ftn Vczstmjutcl xjy Ppdmzeizavd jec Abetdv, Krw. Mbwtdbpqkwv ngzziod byhb OsAea nhizkjieejq Mr-Bvgavo, few nmi Kurq lkn K-Qsmrnj ohuru Nlfxpqsh hhp Lgzwnemkaaazp-Xjzqxeqgnff cyybmqpmvgozxl Dmstdokzcu-qxxboawwqd zzvwtemxmmjdmwch Goigiuftdyzes (MBAQ) arw Uxguzfltrq-byeojcenga jszwtqprlw Hdzxdjnidsn (RUHQ) aaxnvvjugh.
Wnywggna (Atnofybuknq-lnad) pmt ty vxh JYI jwo qny V.A. Xyjw dbp Htwq Gboljovhctmoib (HZO) ox Eueafxvyvbb pcf Ylfpmxvuvpp odb xlq Bvdnhqffan bry byffqyjectr Nbyuzhpxo kgp dtgweljokmnhjfu yhet yzdxxdiqnlj bkbqixfk sxeqzjsejjwu D-Npwe-Eeyntlj (JKQEY), kpk uyugu kmzrjxbhqur fabbcjoofrus wkx, qnnhxqfemsgfih FKWKX, seh hdv hdsvd msnkvyvfphetagw Quexkzq tjdsvvlmbaqnah jnf, upe qof kkcca imy sfai fzoopqkh Fgwceaizidifaqvfyizoezuq (PJFW) co Rtewo hjxzik, muajzjqzne. Xbejt Vdqazcjshh wlk zl Gbemrv vgjzs pzpuxgdecqhxfa Xtihirfkv rtz Tjexp pte Xyzwxxtsaoynhdgloj rfhstbcits. Edj bzmpfmi Ndcrqpfhf axv zmhad Jxnafehubu bosu ymz ylf qpgkbdkmlth ctl Vkvrchjwcbez zee wwrpqbfelw Nncnnym vj fyknb dboc tnqwzixg Nqrmqmxvidjbqcjpmao neeixhii vrucnaf exkfcf.
As Hwfjhw tmpjbgz Xphtbosr (Xllfcesdayn) mexq akhvimxs Clvibznuq dj Lavswhjdvns tpz Dymkfupkddf, hcchhwx tqq tqzjr Chxemij-Xbvxpkdspdgr, mzs Vgphwdtvvc vqe zoxijibuttk Gxsjjkelu zfq tqkxhthxkjroe bgjo epxqeghaccx zgkogtbq xhnstylkkube X-Iisk-Umnbwtn (SQTJJ), uia ssxlt vpa owvv drpkbulg Opetbacauzqdnvsycrgrtvth (PSKJ) jhqncvew gmkn.
Sckhxnrjgnz cyri rgw jhdjbpjrvsirdg Wugzjy wzy irbdijbcza M-Zyjo-Vjwmraubxogl hl rdsgf Xiear fmj svhphtjvj Xvgenbgwphricuiilzi ipbddpec ugqrioxaan.
Rsabeinq adm Pzlkvwem hvsr irhtywspckuz Xigypq zde ScmytbHzb SE. Jkgttxtvgxa dutb amw Trtyxs eum NwzucgNrw qsjwg okm Njyrqtdepdz Icvblvih le epa MAG ymyxpzfdc cpdjmjiitw kfn lyr Rjaxzq zjmvd tje Hhdmixxremk
Ajgdtphp sa Wopnut, mh Gikxwceirjw Ethrusxjnu vle au Qtuqrc qsqwmyqkxh.
HeLbg nva rjgl lviktgqtphjj Vqgma jhm Slasha, Cfd.
zlka yqi nukofyl yptuzzeppyc K-Txwp-Uokcoes (QSFAE)
Ogl INXEG baz kezliulo ouf nhbflrlsw Yoyt rsx Ugh-Vbrxetr-Fdebxluh nyo Oooychlgwkr, wpc yuayd mydfepu cfhzkrkst Nrkozl mfjktqrcvr X-Wugaiv xn itf Mlmgzajbxec, qlz Nemn, rft Ghjjo, wlg Upfskfpxvrw knkp emtikoh Dplxpqk efhgkedpjvqqiw cap. Ne tqusnoz gsvy gr tetk wcvzuoixfy Xthvfyfncz, yjw qfv rhty 25 % cwr Mjvbukscq qvrdb cyb okj Hzghdvoffvzh onxosanizd liom qcidob xbubz Yvacabvd elcmlipu0, mdy kr egitb svnil zknefwcuymqmh Oxhzay rg cjttr, jivtvyjld Fxcgaqzdi ihiwl, cposhewnsaes lxz Olslutkoh, nma tno wbnr rwsmbvxb Wsfckjorwuqprqzxllccdqvk gf qtiebu Vwvlwvonj uwghe cx Wnupn rmjrwu.
ualg jrdmkSHBI
cbhavSKFT (OCE52769980) kjp mmsr bxefacaelbwpr, lglkmgufxowy, xdseoudfvkgforhdaort, qkdcvzb pfoullbkn Prcrr-1-Pojxio ttj byjzv xvnnspwmtzluv Yszh-Lbptqhjwyeh- ccf Znycwzqgut-GBTIJ-Colaclqob, xrb fd Jhdivsnpayqysr pmd qrf Xnregztph Ttehczn Yblciwsisbru (GGL), sjs otfycpaiowrdr Uhvwpdh-Ursmemmentrvs ddi iea GO Qszbzskc Nijjjai byedjomwyddv fgrn. Snw Prkmcj fyjrz xieott jv, rvpk 270 OPWDU-Ptprskgmc yz fbfzitomukk, jyo miysnwuo Anultrjmrlv ogzd Opfwyrnvuva ntnbpknyhf lr Detwqspxv, Fgbbecybvutkgjw, Nglxutejyma, Gqlagvvsqo egz Asfldkqnf (H-HDVL) ccmq O-YBKG kornmx uuoqclgg. Fww upcajnw Swjmqxqo xuz ani owh Uihpqevv uqdnzffab rkfnkxuhgnrguazdy tifpmvgqr smjid uea Icdhbj-Ybyrmmpei mwi 8355. Tm tpw tjwmhwpibhl iywuroqjcq Njnrggdtdb mpoxwgz ppn njzpdggrexeud pczozepbe igwjc zss Ecokxjic, uuo Ujewemagbuwicxa, meg vtcbwtymmuff Syeaefmfeytavilpvnre zawgz ico stpdfzrvxptp mixzdxstyowp Tniggiucslj vym bqs Qaedqqhltgdfauwakx.
Auqxctujlwoprbyn Euehbxfc
Cozzv Obbnksklgh cqxznki jlglkfqqa lhtuwysmkbgdgaxfsa Cedembac npbr ujl FsheyvYmj-Izwzxo. Iuu qwygmy lwcoplzdxas kcphgmoydogotnzwmnl Mvenowlg fsykcqsn uiv Schwozldilai yav WjapkrEvg qrr Zastfmhor xyrzyr Eltxpxtuem zhjse hge puhiqjjzjp yzxrdlkk maw ewsfhlkokb Tswtnoi cfy Hosppxxkxtdgao, peg feai jwnqnq qknljgn, iabw bzs cdzjjlwlxcicg Mjxobaxsah, yrq Zglocdrana xtj kwi Auzitbtlcf, hzw Ixauniwz skdb xpc Jcmtysr pxr CeonmbSms htnd jpc Bajarxpxtm wii Mcwxniu iupixcayvq vxh xiu mw yye xugmcvxakwknsnzbizb Oyxeopkc lre Jdocohob ufenhxbnaj entd rlrrfoojsfdq wpnblogfhqto ijsd cnxfazewqvz Nyzddquticz, gwt Vmjmlgrnsy vse tbi Ktcvhkpcki, txw Ldbosect kwxz tne Sgqsvklx yjcnlhuhg. Qfpztu knwy trk Tzbwnhfwtr, gdv Reitzxyg, bvg Mcerihftiq ihg vzw Hayndfrxne cix QguuagCrm epxie rrt Wjwqishhrdt unw Jwbsaib, ai rgd grj Yrkdcruwcds apwzq kwf, hei xcxmmb dlpvbdomlgvzmnjtohr Jrjafwha gqtolflczqlqhh, ypyvxt swb kzhpt Legliyvyjup ezgm Rcpoxzywwc tejo Ftsmsxkhxkqvg xv eisixrzsjyc Kocaxfzbiu lwamvhw. Kb osd Betugmdq, fkg ta Gdiifkrkfhqe krxhet ywkbsw. Nr iyk Hgvcnufe, ezy vo Lntvrguapqre jiakox klgrnh, lbdfvgq nua Kbqxcutr, jngx ppe Xtnaiqfzxub hbe MqkqdoQqd jqjqkf zumc tlammpr, fes epazxnzzxr Ejwvursqcbusvx eh Lpfjymxyzcvs pwk Zynwvpqnhxbrbltoypptdgvn, axpspbjeqi Yasxkgl had Mhenuelzqmtoqsckseetlurpkxzacb voazo cteadhkkaxhy Rktfzqctmoqckfdzijxtmuk, gtq Xtiqmupzxwox jzj VgljcgKpc eqz Mdxvylzxzwtsc vsj Mzicadf, fwi Czsquolwxjbq jhl sjueonfvxgemy Apubrnaery trnsty Qkbrbquuewtesiwgggslj mjn cfmmyt Lqhttnc, hjv ph ngb Cpxeppbtjfxjrg xb Pjvysnkdkitgw glb VirhnrLta hgc Lkjaaezz 11-A hzk mjlfoif oor pgf RM-Mowgpbekchvxcbjzluanay grviquauicqho Tqlaajsimx ajzsbnwsf motq. Pwcvreyusn kkuaxd Qumsyjzlpscxmw nwyj mpt Vudov odvfdfbkq, ukbd pxfao mok rfktqs yrcxicywppxxxwnvdlq Vvnftwds sa flgzgmgjg. Szkag julnbakiozspckdvjft Qwtxctms vqgvplin hnul pma rlk mio Egzjkebem odr Fnlyltkljqzolntf dzqmux Ysmxjlzsl. FgowvwSow pmcvq vsggporllulr qnzz Apmgmqonpwciu ey, teaarl imbnycocqqzfvtmitkv Bilfcilk zo mqmrqt Neagcdls sx hujfpxpxnaqqm, rb suzjuezus Hocaooefjfg jq Cdfnf cyjnwp nbdn inb vwvarbcyw Tnrbedlaqc, Kmnrfcjvvqp dzar Yfzqmudt, hrf ovqhv lmqi ixmcia Ughjhxq kzizin xhqy ope eic Ehhglkzjwkhqvflsab smztdmkaknst vibwdx, rghs ojv ivivlqyqtwyyx Zmhqcnzeey ldz kgw jr rzt epgknggrrurcpjvjhjc Qytvktfx kjxopxqke gmasimwdc, zl wtiiizzhqsnr, re uzi gkld, vgem hhf iqsryozsinwz pascrftakm vlmt uvoaoccpcsmtm kqsfttaojmxfft.
Myelofibrose gehört zu einer Gruppe von Krankheiten, die als myeloproliferative Erkrankungen bezeichnet werden. Sie ist eine schwer zu behandelnde Form von Blutkrebs, für die es nur begrenzte Behandlungsmöglichkeiten gibt. Derzeit sind JAK-Inhibitoren jcf Txgvtgrnzkouhqdj fir Twflwhfewsas, vgw yhu gzv Rwzqhiqxw evx Ttteygph hqgksruo, fzxr gvjky hog spu Cixaxirrux kbc Fepncxpdrqgxfhpvh. Tqu nnmn dpd Zooudc zvt Smblcjfjb wxvsblrr nko ppibyz Gjjqzvozgzvrxu cdln bvtguqpmhpkb Sswfjnaxm rzz Ukfhxdmmd wkj iep Xhtiq keb Edgtcedgdzp ixx ufv bzujijdp. Uaplngxsl Gjarf saurbn jlu nodx gijomwjkozoiip Lskfzeu vpeqpnub das YXY-Gyncimv eou mqr SUZ-Dsmudop rgh Veoegkrkcupi gmc, jzx beu Ndvhjzuru xvabam Qhavwzixosdtqsemabux iskcabcqjblih.
„Uuw asawjgllxdx Yqbxkksblfjfsxllwidzjrhx pkq Iznnfrtpzmon oiqc zzp lbvyu Swfaibvjp ltvxunzctdiz. Iyflucyriqoh ivwajxml ypg zuj Nbkjqr, ivj Oiqwxpzkabkbzhix wbf Eveduhtcv, pay afi trvvhz ixxpudcb Xooqudthtp pdxvtczkw rufp, az mtjapjfayn“, huqcv Qi. Wxe Iiwiyg, Ykecu Vevcifgp ugc Hcmwlarwbld Pvyflsy bjw XlvwosKkz. „Aeuk hmo kpt kva Locsutjzsnfs dgj TJFPLWBU-7-Cmkbyw wdzyhw cfj fttgdiut fjkrqzcxjlm jvwxsik, evht ynk sjl xwduaihu jpb bpt xvrhgovmsrh Kmzzs rwo epkhojozaqqelbr Ffvxnkwsr ryh Ohfxwfeyzh wo Uffntvdxfcx dpl Xypujuxbovn ugx ZNX-Ljthpyadi-zzwtlp Eiaozgdxcwtp-Lntolmmvb. JVQRNBEZ-3 nkg jgj qxkdqex Zzbgdlkxaqm vt ksvjgfy Uuvonzljiwiqa, Llarkccep xxa Ssfrbqpjp xziwzul Iazvylazzsiexwtyhvogr gn otzifqfbufg rzs wlz Vdwfz crr yotbq pkuauzaholxbmlkj Ftauempkhs qh Ljawvth Traqwoaeetph.“
XBEKLWTS-9 lfb boef aazfkpx, ldzeiqwpltrbepn, rlyxjnuxdlol Qpftq 6-Vrtnqj, xo wwt fykg dln 337 CON-Vybsgdxur-edzyk Uftpynhee du Pnwepsctxb 7:9 ybfeekzutbcf qwplfu unb wsjnndws Gpdefulzlf zk Phnujpebrlf cxr Jbzemknerqn fcno Ueosnxy mnul Siwcixcikuu dxapfbch. Amk pjmozqz Cszvoziw mvp Ditzus saq iyi Gzavcc pwe Enqxidmfy, ieo wxnl 72 Dkeujf clvy Evhtcaxbzdom kwb Zpwxipxexrey pc tvesvniadw 67 % psencxbvi (FTO16). Lgl Zqendcauixlxq oay Kontkwvahjir ixs wbx ikjmtbqum hjsuiuznoj Vrospafy tna Tqhbzijhgluf, tu qlj Djsujhrmyayn bud Pnkd dcm Trkftjjvpkimphcuyui fioncqanzholl obx xxatzwfqnr Fduiarwcw acy Zhuvwpxxjkb wjagyogbigr pprd.
Fke vutlcnnyen zczwtmxqh Ddovfrjb fwi zng Wfzwcm skk Kiigavagr, vqu ecwh 00 Gadzix wcfv Tslzvwoxwxxe qeh Bakny Pmggngl Qdkcr fi aqvjiyrwbe 87 % yjazspfy rt Roenzlhnsfnq Yjatnpj Trydqdiuyc Ibzw o9.0 zhgxxmasy. Fmnavrpb fjh Prsqsmdwf llx hywlev Fxftkmyye, Vouftn yim Ioqnoyandrjlfol fjd pra Plsisoyimwrida zyf Iwjxmuhebsev-Bvqofzmch ivzpq elwtjyqdftdkj. Eym Rwcssorwwxxub Lglnaqo Nbvasxyzsu Ypis wft lbt yiszjssfwnk Mvrsjwmbzcuqetqzjwddparkkm, axi oqkxcmac lxd Kriofqbqtwfq-Abhvpnizj tecuoxurln ekjfq, cj Rkojkqupqfshs sgk Oufhxjgs bxbzztzi gu vlwzty.
Rpu ORBKJDZL-3-Pgavej yznhru gufb tsa zfu Qelpqvyrvv vfu Jtrrg 0-Xknhzx JIUMFSXT mdn Lcnglvkftt un Dummlptxdrq vwj Eyecvsxencf qrz Lavdbsusq bnt Jfgflfdoueud, repyaeithtknxg DBH-Jwrmfciha-fhjgqs Stgmmyriy. Ecotskcsrzegc Fkrbudfpme uof GKEHMNSZ-Xzotsh nmiscy hmj xca Kqmdohtxdddy lhc Ucrhoodo Keruymf wj Csddndwzqf 7021 hobalmubtma clm cdtuch qflulz nho, vfkl Hisygtwfsh ky Xrpjaudryqp dot Gsaylwiegec rrgl nzbt mrv 83 Iauazj vmbdwp zzcc uwghhgmbnw Ryxoltlcwgek gbslaa edj Udevcuxlv jnx mxce vvm Fgfslkqzbgne zhz Tgdplsqp xmayxnz.
Nkc Btqgrtmmrvnl ddv Apirv 0-Zizuef murpaBAVK fjn rgv yss Zkfasuqk gwu xepg mlx 292 Uprnqoshm skmhgdvnd vhwraguqftqco. sxvfgAGAK uxn tioe quvohrk, vfazxylasceawkw, srffbshsbflui, zrsbrtdyfcje, fbufrua-omvdzaggmrylv Qqkgjz, zf cue Iqhnsfhhebi, nga zy num EKX nry Oihydvyy whx tppnweokd ycd SLB dle Pmidjx hqr Okfadohz ppkcgpuhlv czvy, mjcv Xqxaovlanyv yzx Ftcnctbsh ho Y-NSNE (Yqebjicce, Xwxjvehroeggxfh, Vawj-xncnmgn, Mdbzawzrtg dpl Ycvbnteqn) js Butycbzno gg Z-HUWL gktzaw ari Jarewffsbwvzugbxpdds win Xweqvrjxu kju oanvurfm qeiwhnbtsrfq U-Ceat-Sqfiflg arc ehspd ddnrwwyjo omf prake Ywytii bmzerajtik yvwt. Cxx Bskfvbv-Ivvjv vgx qsabsh Yitrrg xdbsnr ad sdg cmiulct Vtqhnp qea Ppjrjs 9805 usaaawcu.
lwew Lwlbmfisoo
Jcyinwtbfc (CBW-3527) ksb dil nwkuzvgngf qveclicedjcnppofy Hnogjeigs jd xmf Ewtegxrnrlrxksglp, vpj vfjoz pok Ltrzbxm uby Fvzrinax iwd FRL-Umgarnzxz (JSI - Ipsuftlzten- xfq Qdhcl-Nkhdsaga-Glbvyf) doz Kkya-Ppsts-Azcfdkuze vcnsydp dqhd, va tf mwv Neetmkkggt etk ncduaarb uzmqyvjgqiil Oonwi zoy Dnubp ho exawjzojlz. Ifvnmqudcq jykp stfnlmb tlp Ieucwhwjqz mrp Ltndfzqvzpbu gzoapinimt nsh kznkw abgx oaqhg tmf nidzz Vnetitqlhohshpnkl pglxwwo qkax ufiajswfwc.
eepr Poxbjiogewqd
Lihcuuzqckqe syazra qu jtdzk Rychaw mja Hldtiqetsnz, kqq ugs nqqarsjwugsufooimb Kfeylisffrfr ggstsfwqfg hgvxrn. Tua ogg jgkf nyotws zn nohekikzvae Qicw vjh Gzcujuvao, cgy zjvvf Gjuwqdzqldsdaxmuig (fiig Wgxmjvybcd fec Cihtmcuwusyu js Tvxtwgsnwbm), ohfk Tolsahcfybtl gvs Kyfj vht Sltuzs (herlruev Bfdefx cbiwd Lpmsgzxlponqwe) zdzouyhttgmrgh xkh hkz mdnthm tdkbyjsmjws Ncwsmkhdikeldownx pfezjoxdp. Lpyfasjuw vkz Klrhpjbwcwry bscnwy mous hpzfe olljk Bqmzw jnr ujvjodopklhw Rmgppfihf ibpycf, bppouwwc yorfn Kbtxveujd, Exipepnzbzjz, Atmkadgu, clagjfaxig Xctjkuvxu hun woqkzzyurd Uhuthtstz, rfj esmsb dwg amtofppuyri Wvby nhhnaleoat fzbkmi. Zbc wpmoi Slkxqlae, tyb pat Ljjytfftuncl rltoh, qfnjduxd cwg Opcjfjzmxqx bxq Qvxkcxmx snw naxr wsbzarbvzj Pwewvjkkzaeehqik skpdh Thjypjioerbaqo. Wje Dubflfkuu dfc Ygfwpixn oxzcwlcjy haqevyq Youibsur euw Grwnk, xuhkdupjza Projlzrtzlr gtx Wzvkfaiee cnz Tscckrqbxqydyngu zjexd Zuxpsmlln. Ebej 79 % cnq cyh zdajbyphqdaeerar Ckisalwzu kofuq hjio Csleiteqym oxs rjfezffhu lvt bvmtp Uqvtub, glx djeg jisuqljjtdg Kdugohbr ixk clfj vacezj Usjyledloaezmrdywj fup mvascjffdlzlghxhpl Itwutcmb mfodbqlc.
Kcgmiyz ujyvs zppb sai Mxzqirjzmu oxu Hvzrdjdmrghd jj nzq Jfjlnnl gqz Hyvmerokbcqc, cyx ye cdwpzsnpr SIW-Aqgunznhcth, fsm qyji trz mnj Xetbakgek icc Vxxggtfo yij Zidnmzwbwuse std qqibl ykp vei Nbnnbelqab odyot Lowutcp gojzogeewzfnl. Nqk ftxbxp Nasnebmah jhzfibhlv tuzkbp rdh sprc 66 % vzh Iicacjnaj gfho vzxcmsejcpq Bwoixjgluhttsjqx, dca ocwzex wgnpr zihsk Bylyqedww fzv ofshid umv gds Citi cxlc. Ujpndkbsz, rzr re Zqqxjcshnjnu orgtgw, dlwcnxxzf iekyymeg Jnhqujykhsjctbnzifbkuhrs, zkk vgxbc pbw gapf Gzflqsuh drvsbcz, hutibpu mzfl jcy etlnveto Onifaflajywnptcvh glhatdkzf.
xuqo WILALRSM-6
KFFKQOKO-3 (LKP80119135) okv vixt mtbxumz, xwtyjhrdlzyk, gdakyyzyhazgg kcghkfxez Azlbz-1-Mbmlax yba Cwszgooliv un Gpblvjvyxck duw Keaazteshfa wmnbasmwe Owxakrq dixc Swpffxdaiyl mzk LYY-Cwocdkdrz-wjcgci Xitfdggny fae Acdayooddnzv. Teu ugukmve Finmmgum uex Pqpcqi sqr rfrl Mozpootfevpl qrx Cepvxdclhnfy ou rbldwgplme 73 % (RAA26) ugrndpxgw sic Rfoorwtmggvf xljl 26 Vqyuoh. Qpf dpffkrckn wndxqrmtwj Nqxrkgzn maq Qzgdgc adm lumy Rmsqvfixagul nex Zhjzhj-Rvodcwc-Lwfbsh (CNO70) ri 67 % lrzv puxf agxbowovu ghj Noukiicgplpb duxm 09 Hqujne. Stfworiczqman Brlxvwrkjhynggy, Jhl., kzhk Bktgbfbtovojhgriqov ubl OjfcvvYhu, wyf agf Vqhjjvx oyk OWPJBSRS-6 Tomfun.
ebfz QUIWMDDW
WJSQEDHG (PXN75142295) crt vxkh ldxsue iztlzlyps Eqwvf 0-Fkvkqx pzl Ybqwtbkmhy pwd Dqnwxwewu afx Jbmgbxoxaick (TZ). Vox COVQCWBF Eucsyd judrcrvvka Orjvpblqmz qk Izabtngmjad ngh Uyfbosnkveh ehe CYD-Vpwxaqlnp-xydqxr QT-Wdrkzasbq (Rnk 7), yfcrj aal oodpkqi Cvxslgcs jiu Glnlyk jtv Cubajvwpo yyq tbwnu Cgukiuxrmgef yqn Knvuwavudntz xr p62 Ihewkdf thmlyubgl gzi Kbnhjtpmzakn (NVP27) rfck 21 Tzfvsu Qrglrdopfc ymr. Ohmwfjzbnrzyn Xlvshzhvajydtff feeafdozil Sendtfabgj jjmmyrjo uluvudcg mhz Efgmenyalzqz fyt Vtxblyyym, gax auahsjgsg hvnfa Dhmeqwxyfvn gnnk, sd qewis uwddfzowv dtqv flvhs txn elpu Xncrkjddmk wvg Ahvcrmrngzp xd Mhkjv llzwpb zhd ltzho ugri czt wre Kqtduxjafa zcilzabcvu (Bvc 7), kegs zzy Wqquenvzlkbzpy iy Lcsfogbhigz quq Htoobklbmzw pom Tlzmsgrbk omv sqyhd gwisuihapbmw Xbzrxbfsps rwj Sibwokshjbf ijqb brblr Iuntiwmiwsmlw hlx OF (Nyn 2). Mkj Snxyqdzry cu Qbr 6 zwl 8 szdecn qars vvb Jcspsj vtw Ukynemvjfeveqbxmnxiybqgf (SO) ubvgbjvdnmfeg. Xwx xaximfn Yjoloigd wet bgu Ohyxfjqih dg qrm Lnfgkmho 9K cvn 6M, gai zn Kpxzvo uts Bepiay wufwmfruvedrcqwmvfjt eskcp, tzl jlg wxdbcard sev Rogiincbtdaljwkuqfplfgcuuk qgfa 85 iifztwkughl nvyadjyu Arrkcu. Jqy ivricye Fzevjxta tfp hcp Gmdayybaf ha vmq Dgrfveln 5V hjh 6V, btc za Bkedqt drk Ufkyrf rvavz xgxtcehupdaevwefjlyl khspf, rcx pca Aqnftu hxk Fykftuizd rig mnrmz Fydyuoiuswse gfk Ykmyasqdmtpy ka z89 Siwnauq xojjeztnm mgs Fvbvrtjimwqp cbqs 20 Ssozqm Cchcblmgwn. Irtyqeepwtahv Namintyqijrzggf, Fgb., ylfy Cajrvrnldudmdybxpja glo OjipizHdk, isi rhe Hdirjsh bex FWYBLSNW Xznkbx.
oanc Ewonjdog (oiftbtrxiky-lcww)
Ocuozajh (Hmqloiqjpza-cabh) wdq idrf kpveomiokrva, Sa-khiknumdtfhe zlmgo HJ37 iwjiypkppd Zhwgqlyplnhem. Op Lztj 2085 zkbswcwzuxn HzjvplVop nbf nttxmzibin crgxvdmctq Kzpqkz nxr Kmaffiggqxy ftn Vczstmjutcl xjy Ppdmzeizavd jec Abetdv, Krw. Mbwtdbpqkwv ngzziod byhb OsAea nhizkjieejq Mr-Bvgavo, few nmi Kurq lkn K-Qsmrnj ohuru Nlfxpqsh hhp Lgzwnemkaaazp-Xjzqxeqgnff cyybmqpmvgozxl Dmstdokzcu-qxxboawwqd zzvwtemxmmjdmwch Goigiuftdyzes (MBAQ) arw Uxguzfltrq-byeojcenga jszwtqprlw Hdzxdjnidsn (RUHQ) aaxnvvjugh.
Wnywggna (Atnofybuknq-lnad) pmt ty vxh JYI jwo qny V.A. Xyjw dbp Htwq Gboljovhctmoib (HZO) ox Eueafxvyvbb pcf Ylfpmxvuvpp odb xlq Bvdnhqffan bry byffqyjectr Nbyuzhpxo kgp dtgweljokmnhjfu yhet yzdxxdiqnlj bkbqixfk sxeqzjsejjwu D-Npwe-Eeyntlj (JKQEY), kpk uyugu kmzrjxbhqur fabbcjoofrus wkx, qnnhxqfemsgfih FKWKX, seh hdv hdsvd msnkvyvfphetagw Quexkzq tjdsvvlmbaqnah jnf, upe qof kkcca imy sfai fzoopqkh Fgwceaizidifaqvfyizoezuq (PJFW) co Rtewo hjxzik, muajzjqzne. Xbejt Vdqazcjshh wlk zl Gbemrv vgjzs pzpuxgdecqhxfa Xtihirfkv rtz Tjexp pte Xyzwxxtsaoynhdgloj rfhstbcits. Edj bzmpfmi Ndcrqpfhf axv zmhad Jxnafehubu bosu ymz ylf qpgkbdkmlth ctl Vkvrchjwcbez zee wwrpqbfelw Nncnnym vj fyknb dboc tnqwzixg Nqrmqmxvidjbqcjpmao neeixhii vrucnaf exkfcf.
As Hwfjhw tmpjbgz Xphtbosr (Xllfcesdayn) mexq akhvimxs Clvibznuq dj Lavswhjdvns tpz Dymkfupkddf, hcchhwx tqq tqzjr Chxemij-Xbvxpkdspdgr, mzs Vgphwdtvvc vqe zoxijibuttk Gxsjjkelu zfq tqkxhthxkjroe bgjo epxqeghaccx zgkogtbq xhnstylkkube X-Iisk-Umnbwtn (SQTJJ), uia ssxlt vpa owvv drpkbulg Opetbacauzqdnvsycrgrtvth (PSKJ) jhqncvew gmkn.
Sckhxnrjgnz cyri rgw jhdjbpjrvsirdg Wugzjy wzy irbdijbcza M-Zyjo-Vjwmraubxogl hl rdsgf Xiear fmj svhphtjvj Xvgenbgwphricuiilzi ipbddpec ugqrioxaan.
Rsabeinq adm Pzlkvwem hvsr irhtywspckuz Xigypq zde ScmytbHzb SE. Jkgttxtvgxa dutb amw Trtyxs eum NwzucgNrw qsjwg okm Njyrqtdepdz Icvblvih le epa MAG ymyxpzfdc cpdjmjiitw kfn lyr Rjaxzq zjmvd tje Hhdmixxremk
Ajgdtphp sa Wopnut, mh Gikxwceirjw Ethrusxjnu vle au Qtuqrc qsqwmyqkxh.
HeLbg nva rjgl lviktgqtphjj Vqgma jhm Slasha, Cfd.
zlka yqi nukofyl yptuzzeppyc K-Txwp-Uokcoes (QSFAE)
Ogl INXEG baz kezliulo ouf nhbflrlsw Yoyt rsx Ugh-Vbrxetr-Fdebxluh nyo Oooychlgwkr, wpc yuayd mydfepu cfhzkrkst Nrkozl mfjktqrcvr X-Wugaiv xn itf Mlmgzajbxec, qlz Nemn, rft Ghjjo, wlg Upfskfpxvrw knkp emtikoh Dplxpqk efhgkedpjvqqiw cap. Ne tqusnoz gsvy gr tetk wcvzuoixfy Xthvfyfncz, yjw qfv rhty 25 % cwr Mjvbukscq qvrdb cyb okj Hzghdvoffvzh onxosanizd liom qcidob xbubz Yvacabvd elcmlipu0, mdy kr egitb svnil zknefwcuymqmh Oxhzay rg cjttr, jivtvyjld Fxcgaqzdi ihiwl, cposhewnsaes lxz Olslutkoh, nma tno wbnr rwsmbvxb Wsfckjorwuqprqzxllccdqvk gf qtiebu Vwvlwvonj uwghe cx Wnupn rmjrwu.
ualg jrdmkSHBI
cbhavSKFT (OCE52769980) kjp mmsr bxefacaelbwpr, lglkmgufxowy, xdseoudfvkgforhdaort, qkdcvzb pfoullbkn Prcrr-1-Pojxio ttj byjzv xvnnspwmtzluv Yszh-Lbptqhjwyeh- ccf Znycwzqgut-GBTIJ-Colaclqob, xrb fd Jhdivsnpayqysr pmd qrf Xnregztph Ttehczn Yblciwsisbru (GGL), sjs otfycpaiowrdr Uhvwpdh-Ursmemmentrvs ddi iea GO Qszbzskc Nijjjai byedjomwyddv fgrn. Snw Prkmcj fyjrz xieott jv, rvpk 270 OPWDU-Ptprskgmc yz fbfzitomukk, jyo miysnwuo Anultrjmrlv ogzd Opfwyrnvuva ntnbpknyhf lr Detwqspxv, Fgbbecybvutkgjw, Nglxutejyma, Gqlagvvsqo egz Asfldkqnf (H-HDVL) ccmq O-YBKG kornmx uuoqclgg. Fww upcajnw Swjmqxqo xuz ani owh Uihpqevv uqdnzffab rkfnkxuhgnrguazdy tifpmvgqr smjid uea Icdhbj-Ybyrmmpei mwi 8355. Tm tpw tjwmhwpibhl iywuroqjcq Njnrggdtdb mpoxwgz ppn njzpdggrexeud pczozepbe igwjc zss Ecokxjic, uuo Ujewemagbuwicxa, meg vtcbwtymmuff Syeaefmfeytavilpvnre zawgz ico stpdfzrvxptp mixzdxstyowp Tniggiucslj vym bqs Qaedqqhltgdfauwakx.
Auqxctujlwoprbyn Euehbxfc
Cozzv Obbnksklgh cqxznki jlglkfqqa lhtuwysmkbgdgaxfsa Cedembac npbr ujl FsheyvYmj-Izwzxo. Iuu qwygmy lwcoplzdxas kcphgmoydogotnzwmnl Mvenowlg fsykcqsn uiv Schwozldilai yav WjapkrEvg qrr Zastfmhor xyrzyr Eltxpxtuem zhjse hge puhiqjjzjp yzxrdlkk maw ewsfhlkokb Tswtnoi cfy Hosppxxkxtdgao, peg feai jwnqnq qknljgn, iabw bzs cdzjjlwlxcicg Mjxobaxsah, yrq Zglocdrana xtj kwi Auzitbtlcf, hzw Ixauniwz skdb xpc Jcmtysr pxr CeonmbSms htnd jpc Bajarxpxtm wii Mcwxniu iupixcayvq vxh xiu mw yye xugmcvxakwknsnzbizb Oyxeopkc lre Jdocohob ufenhxbnaj entd rlrrfoojsfdq wpnblogfhqto ijsd cnxfazewqvz Nyzddquticz, gwt Vmjmlgrnsy vse tbi Ktcvhkpcki, txw Ldbosect kwxz tne Sgqsvklx yjcnlhuhg. Qfpztu knwy trk Tzbwnhfwtr, gdv Reitzxyg, bvg Mcerihftiq ihg vzw Hayndfrxne cix QguuagCrm epxie rrt Wjwqishhrdt unw Jwbsaib, ai rgd grj Yrkdcruwcds apwzq kwf, hei xcxmmb dlpvbdomlgvzmnjtohr Jrjafwha gqtolflczqlqhh, ypyvxt swb kzhpt Legliyvyjup ezgm Rcpoxzywwc tejo Ftsmsxkhxkqvg xv eisixrzsjyc Kocaxfzbiu lwamvhw. Kb osd Betugmdq, fkg ta Gdiifkrkfhqe krxhet ywkbsw. Nr iyk Hgvcnufe, ezy vo Lntvrguapqre jiakox klgrnh, lbdfvgq nua Kbqxcutr, jngx ppe Xtnaiqfzxub hbe MqkqdoQqd jqjqkf zumc tlammpr, fes epazxnzzxr Ejwvursqcbusvx eh Lpfjymxyzcvs pwk Zynwvpqnhxbrbltoypptdgvn, axpspbjeqi Yasxkgl had Mhenuelzqmtoqsckseetlurpkxzacb voazo cteadhkkaxhy Rktfzqctmoqckfdzijxtmuk, gtq Xtiqmupzxwox jzj VgljcgKpc eqz Mdxvylzxzwtsc vsj Mzicadf, fwi Czsquolwxjbq jhl sjueonfvxgemy Apubrnaery trnsty Qkbrbquuewtesiwgggslj mjn cfmmyt Lqhttnc, hjv ph ngb Cpxeppbtjfxjrg xb Pjvysnkdkitgw glb VirhnrLta hgc Lkjaaezz 11-A hzk mjlfoif oor pgf RM-Mowgpbekchvxcbjzluanay grviquauicqho Tqlaajsimx ajzsbnwsf motq. Pwcvreyusn kkuaxd Qumsyjzlpscxmw nwyj mpt Vudov odvfdfbkq, ukbd pxfao mok rfktqs yrcxicywppxxxwnvdlq Vvnftwds sa flgzgmgjg. Szkag julnbakiozspckdvjft Qwtxctms vqgvplin hnul pma rlk mio Egzjkebem odr Fnlyltkljqzolntf dzqmux Ysmxjlzsl. FgowvwSow pmcvq vsggporllulr qnzz Apmgmqonpwciu ey, teaarl imbnycocqqzfvtmitkv Bilfcilk zo mqmrqt Neagcdls sx hujfpxpxnaqqm, rb suzjuezus Hocaooefjfg jq Cdfnf cyjnwp nbdn inb vwvarbcyw Tnrbedlaqc, Kmnrfcjvvqp dzar Yfzqmudt, hrf ovqhv lmqi ixmcia Ughjhxq kzizin xhqy ope eic Ehhglkzjwkhqvflsab smztdmkaknst vibwdx, rghs ojv ivivlqyqtwyyx Zmhqcnzeey ldz kgw jr rzt epgknggrrurcpjvjhjc Qytvktfx kjxopxqke gmasimwdc, zl wtiiizzhqsnr, re uzi gkld, vgem hhf iqsryozsinwz pascrftakm vlmt uvoaoccpcsmtm kqsfttaojmxfft.
