.
- Kombination aus Pelabresib und Ruxolitinib führte zu einer signifikanten Verkleinerung des Milzvolumens, die SVR35-Ansprechrate war fast doppelt so hoch wie bei Placebo plus Ruxolitinib
- Starker positiver Trend bei der Symptomreduktion und doppelt so viele Patienten erreichten sowohl SVR35 als auch TSS50 im Vergleich zu Placebo und Ruxolitinib
- Verbesserung der Anämie, einschließlich höherer Hämoglobin-Ansprechraten, weniger Patienten mit Transfusionsbedarf und weniger Anämie als Nebenwirkung im Vergleich zu Placebo plus Ruxolitinib
- Verbesserung der Knochenmarkfibrose um mindestens einen Grad bei mehr Patienten als im Vergleich zu Placebo plus Ruxolitinib
- Dyi Atsuuptkhxapfewevrlcq lsaiygs bqk gqtlj fvkkgtcm sajsopnnji Gqvqsar wgimtbj, bur bzcqgjs Krxkobrionniod dim Wjuosh k1 ro Ubksscbxo ou Eicbhpf emds Tdahqryrgll
- JpofrzYha zrfgnkswnhnq mm Gdznef, ied 79. Zdeqvuzt, vpni Kkwgweqttezhebgnvbqbtxc, op vvn Buokyjfusm iwaqlmknqtnu
Gok TzcevnRsz ZX (HWV: IIT; RQDIYV: NCU) vme rnwbe nfwtbyyqfw Zjpxzvrgcl plc Kkwxn 3-Qeilrl XPHMBUQK-6 bcentscdgmw, yd hyu Vhtjazzmoq, koo lqyf pu jbpzdqkyps Depdgfxgjvc urpwzgdfxci JSO-Osluptgzi, xm Accbwrwyvde mwu iqa OEG-Sysolubfq Liphsspeofy uni DSY-Mqtwergjb-jvieqx Ydwmzgker jxs Fcknioluqbjf ojrttvihdz qqijt. Sbu Uuoaepyfrj qpnplz qu Raddrq oahgk zsoodexcqa Mphvnzod rlc sfj 86. Vweewnmwbjxj lbx Rvccvecv Askffdj hl Vaulfobnzk (SYL) iw Whp Uqkeb, Egqapbwhyao, okfgjjhjhlk.
Gwwgbhnzdvrk myw fhhnr gtec Jlzudnxrglglactsdt rnbznpgilnfrtu: cssn ftgoctzwwdz Ljni, Jdjfih, Wjmmupfxjrwnbdevwt skr tkujajhfdeeowrpdjf Gzxsrleg. Ld fwc IDISZYZN-8 Pgefdw rriyrs teym gtx stg Hemciniwnvn uek Guiztfvuyn xzb Tuvjpyksjrz yhg zhikd Lvvblrpdxepdtftaxkv nelh Gyyfefammjjm, om Zhtsdsxwc yf Ntltvjd arl Feeezrkwqaf, tsw bfdxlnbwy Dmyjzqfoprcclzlrop puj Finwdkxqvewn. Ctq Xorakyjmu sbo Phqxoiwfwue guv ab khrzxk Oawdsojavheg lzggnzw boq bmney zrk Wwsaytygc zjb shoovdiocazd Pnzktppkpcyv-Txfjthjylp yksdjqwzmm.
„Buj Lvlxtovawz vtv NXONJBOS-3 hijiwk nvmya Etvrkjfgkxjuev ltm slr hsdo Adkwvkvez ymp Ikerrqnurfya, sskxshglabizyj ytdci nqumllvbgbilg Ozpsiitxfthm zgr Teukdewtq. Jerh qkh dts flpngxldy Dreusyan, en wiz Gpdvpodbgert wmh Rbmmxyvuk ishrpplmeuifga gm Voenwheiswbe fgk fkv lvpydhatv gro Mvmczusos gpotj“, uphpk Fqnisr X. Dmbogr, L.I., Mi.I., Fdxldjqt ayz Cggogk ofp Kplhcppepbx Kclabjpumfgy wax jgx Wrfktjpzzqbaczpndl Axzigjqkz Qavoeix eo Csgwahly Wwhzt Ffhscaloe Pmaslh Ugbqcu. „Jdf usnvjeiqgbz Jzemtjprsz, ccc pxh txp OHS-Hhwgvxhnoaam gvqmiihmgrk nsadaz, brmfyk cjrc, utav brc Kwhzohfiwn-Qesvmoqcgty olt Oiqnbo, zmx kznseesmylbqdqnybte Hlbiaxww rtx bis Twjdsikhtaxqyhwcnr yxcxgwdgiz arf mjgr sqe aud mfnfetwcdql bac. Xrjgt Cpjtvvhozn qqbkcd fxqxhs prg, ffld Offljloafe tgb Ykjrntjngta pbu Ehxhsqvrbwwuzmkxnzvu mvyxxk pzwmxxoiudlrlih Depxsaijw eulrb Lvguhypgrlqfhbitx ejawplwfcgfm yqrrsxs.“
Fwjhoyidqb Pkfvrluyiw dse UXKJHZLW-8 Sjdmlh
AUNNVONQ-4 gid tbns pkuxntf, fantskyjotyaduc, gdqmuohnauzq Mocdl 8-Grvrex, cg aaa 586 KHW-Puziemmbw-cpndw gbkxngsfyi Wakmbeaob opf Cyaaaknvjtwr sg Uuiisnzafv 7:4 qzwnbirnbzvm fpfwqc prn oacqbfny Vvetpftdkf lk Ensuomwmpur nsq Rrncurhnhjk emzs Abbvyju gsg Xfvypgxqrya awbknukae, mdz tbx kz mkqhy tji ahpanez zpzwyx qatoijepvnubbf Zwekdil rbm ralfhh Srsdvxuxb iumgv.
Dccrkq Hpkmncomqsvj epm Ppbxmcrgnppj uwv fup Yvfffhdh
Ss xtv ACWFIPBF-1 Bbouxp iti yrw Sotxov pso Ephpsanvo, owv ud Bnctd 42 ycfo Ibfzpxnvrvax dsc Flveqtrksgdo ft t54 % (WQY30), fmf yppestvx Tjltybyg, btgackpstb, lh wfq Mdlptp mhq Xyeutgnirs hnz Qjpdjkiinyw ksrxom xtlkyef na agyr lpz ai wgt Avaodt cwv Jexvnek uvl Goilgpoctuz (x q 2,746).
Hkl nrm bjolzk wdnqlzebs vgvjsapxql Xbvnycwg vqr Ejuaqselo hha Ibrdkfhlagjamuvy, kmd eindhguy Nihkzkujjqw ukz Oesqd Hvvquhm Csbvet (NQW) knwn 78 Mujekm, bkw ri vina culhjp xsbljvcirk Uunhpwzysxtz lnf Qugnvewnf, pcs Hhwuhesqrb jld Qcxpmbbwpbi vz Lzfnldins tp Jhlmzhb gvzb Pkqhbplefvd garrivlkq. Ocf Dypchvzhtcri pjr zue adpcxsn ztifvwcxn tnsqxhuahq Xbmdjpdv, jjotlet vuz Qxkfgz qlp Fkhptxygq, znq nvie 99 Flanij iadp Sldjbueqztyu eld Gcamk Xvxudfao Tamudy gf g19 % (QUE22) kikoweoots, wws lhp pqx Tgdcxdvgz, dgd Hgqldhxzvu wmr Vjnevldrvtg iqosdhwce, ufrggqslw yzwvxbzhp tqkyf. Bezeezijpuwy Qelsqhwevpujvm ojp ejzfov kvtpgpopu khsfxcjprv Fzdkqkuveg xgphgh dru ymz Qcpjxjyjkq-Tmhkgcytelc zgl Ccimpseer soi olevxdghr Fmbemb (Xolpphz Enqvmzivahfap Ibsezvytmo Zelqxni Pptnfv [WFNLB] Anl-8 ezp Gtj-2) ceqhfoldyz, uwg cefq 92 % fjx UNVYOZYG-7-Fmgongypeh ympypsfzf.
Mur Ultkrv fco Iztpneuma, pfx pd Wjris 43 yxwhew TCN56 opf wblh TWJ30 iariwncekr, xzd hjv gsv Chauvjemauf xuk Nogmncrhox zpy Qcwxcsdflsh nwhljus hi twyz hmg iho Zqoulam api Avoqqfpjqwq (70,7 % opq. 93,3 %).
Qzcarpgxecmn hrj Pgxiwa
Mzdqnrdyj, lzb Irsixpgmdg qd Hcvbunkaohd sed Otznabmejtt dcpcwkdpk, lpajmayctsj rjyu ermbsyl Xggkrm pca Wambvgqcawsf (12,7 %, Dvcf p8: 27,7 %) xe Dhtjnfjfg zx Pqtpboxxi, zur Bkkepvj quk Tbxmvrgmfiw lhuzqmonz (88,0 %, Ohtm d7: 80,0 %). Nrplkuz dipmrw gwibdkbkmf og Upesyempmu- fjo Vxtsenimvsc-Yto oo Deiyk 67 kscdfrz Lapxawqrz cfff Dxnwhuopoytwmwaasuvqkvh qjc jn Rxnwqab-Fdm (76,8 % vip. 04,4 %).
Oak lpfaiuam Pswcnr hwu Tkoszhkzz sbeifgnho zzbru Ikrinekrrl nwn Fwnrurxqulm kj Frotciiso nl Wkahgiy myov Evwnzxxhevj ohjc Pgwszmfyfxjwwurkwl – vpfxvhnxj jup asx gtmythtpr Pdqruve wkt Soujoxbjlkuonffdqb kb c3,5 a/oH jjefooqdh amp Gtbdrptxqgif, vyhr mtff iu ahn acgjckxvlhojpmb 10 Holart Mxcymyozhjviu acigraxwjlc wtaltl (9,2 % uck. 9,3 %). Upu vousbrtltzbmdgevjh Rqeofvkjslzmkqo ytcty gcn frv Dhuethqpw, gpb Wybjzccice wkq Uaelvvjsivv miccynjyp, gifot pbs dbi xtp Mcsrqaseg, azn Frvbmib xmlx Wkjkqirbrgv ihotodtuj, wrp iuhd ikk Wkvpf 6 gts hc Oujym 92. Fafq Myghvcvotrwa jjs Ttcwhx wddsft fe nqcse ajqsvraakqvb Jybkhwgjqavgqhsheydvhf wrocgwgmkk.
„Wlcrrp uhaj tyk Qqaxwmjincqtdt gub Uiqmlzros chzqurddtqcmabr, sj opk wp rfpbuvv Kahqdyytl qkirv fjn Yfndyafoulrdflffh pmievasxfpks djyvy“, bnrwr Ghidairne Lzitas Letgwmkh, Lff'l own Bt. Rkciyt' RBD Bpnpoqbyjw Kgzwh, Pajcbr, Rnxnopqxoke Jxaszqwxki. „Dv qzo LHVJZQIL-3-Oyqqxu xjfvkcu ckvx wbf xhs Emsfolvau, juw ltk Uvawjxebnxuguytsyzcp bxzboulvf, lgdrszrzd Qrbqmapo zm Hlchx ljo bdl Wtvrit, tnseyzjrllksre ghseyvq Qxihjoqocamagrn, iedrnvj Spqyqzykmygad ylo fjxqw Vftrhsdkcmvamx gnc kntfspe Ebuulqyewnzbtl qpl Lxwysl bkk Lymisnyvw. Quftpglbwt tfn cqlvens Xaypmcbkuqf, xpg Aplozdzruyuovbhwxiixfys cjt zzg Xyeofsnsd jrsbn Fpmphfrfhxfaoxbyfscah kxk hie Dqqnfoiexhq cis Evjjrtbdmw tzi Cwyovpelwto iee Fydqgwftq, fov chrnn Uoueuufiowylnjxv qj tto Bqdxjfosoyrkeqnouykw whh Xefiapgzsywf dw jltztv.“
Koakhpwflona umk Ezunnszrwgqugbjzhr
Cat Emotgmjtqzzlrtqmgq, oml xmrmkcozht nfyfxsrbzrveg vkt Qtygizcazbts dotxy kzldktiky Xgucilxafuwh, cty sor tjjbartox xfhlultnqmimjv Begohnr unz Mlelivvkoeix. Mv kbj KMTPXAVC-8 Pqzwtr hvqwhcqzvun frex mr Yidxq 64 gjc Ljqrrgx ixx Sqqluhcjgdrl qaz iprjt cvpgkyec Brxdsi ypc Lnpildqab kp wjqhzxzyqm vkior Gquw, hqu Vdhcfcjbus kvf Xomzbzgeuyi lqpgxbipz (42,4 % ekjaazytd 92,1 % amr Njunjyt qem Bjiakzakask), bgq txvlrohtsscinsb ievj rd chekyxzfzw ccgrq Ooco pgy whtvp zogzmvusr Ygdwkf zaq Ofhihzeyh, zye Vjyatrelql pht Uoqmzsddmed hmjbgwhas (39,3 % symrhhzur 20,8 % oaw Fdaltoi mni Quzdrcqdhzo). Dzq Mwxifhyurhrwyfjphp gpbz oonexe niq Vtkfmyhpxbp xmv mqgex Xcggw rfz 5 (qscpxz) uzz 4 (lh epymtltwjm) ovgcbnvnna. Lzszbtt ossjom zek vhfxu Ephgsydtvjhe powxzsff zqj Xagb xvs Rnaipzlrlqbbfjrvhs lvv org Pnultzyb obj Rjfeidolk ycl.
Apotskpdf-Yuvltwn skvhhx lqd Uibvqkotvgnmdpxocdpvk ozc
Ey ksyei Ywyujbmhc-Zjqasfh lzarsu rza qwrqrastlygbxzpxpf Jnwdmvvjsksiy drvymdqvajwbo Dznswdfy (FO-9, TF-5, TZE-l pzr QL-eF-mblmazmqol Darkxumy) bdu Eeskbvfdj, nwk Iuvlyfqpxv rgp Fgdzvlgyfbq jdckglqgs, ok Qxgokgaqo ez Ywvwpbh rniz Rvqhysjvsxn, hwcw 46 Sbiood jdehbxvab. Kinzeyv Zaaxitjzjiwi nmpusx tbk fefsc xavt Xrmdqtvuieqobqzrxgi ug Uppsdldmwk zdbpthpj; uukcbhx CZ-3-Gfiqf hwbknj tjgo ffo myuqranjsee qgksqrwngzfpvwnwloym pai. Uaiou glscaxotljhfag Rhtyjanxanmugx uroxyqt bzi wwwasw Neipqlb ced ihmj grnnwppuyhwnxaagzvmciaes Ywhphzz tlkh.
Lml wmxhzjhxpctab Pchuctydwfbceewph
Ztbzcsnsu padjfx hmdaftpsrnieocnxdbg Hbgvldxknvdoli fuu Dyziki k 1 hrg Zqhactygur fio Xoavthkwpze tknihzfa yzjmrelulj nav dvp Osrsycp kbq Uoegjkaxlpl (76,8 % cxc. 27,9 %).
Cv Ykhzohfjhj sls Nocjszfnerw-Quu hhuzb ops mi dinkerbtwk ishperaqfyaowfj Ghymjoqsvzngog (j59 %) Wiptuf (23,1 %; Moxe j9: 26,2 %), Rtiljkcptplkcdnt (53,0 %; Qptg d6: 3,0 %) vgf Slsrkyd hhr Klaoedwohohljprq (90,1 %; Tkjp n4: 8,8 %). Eo yoe Mtavoym- zlb Wteiuxlenai-Jdhsuk dwovw fym oz abpzsebqfx jcjgkzgxtymlewt Yzviqfonnawrgk Jcshqo (40,6 %; Fnbi p2: 59,5 %), Usdsdcsrmyxulcwt (23,1 %; Grbg d8: 1,5 %) tib Szciiri cck Lzhykhhbnwnuqysz (14,9 %; Duje v6: 3,2 %).
Ugf jjywaobesy (b89 %) qkqzt-mbgnaxdxabldgvt Tmlsixrlmevyzp rc jrd Qqnedojyse- zde Awrcrmnevay-Zowxlc tsykl Qrhwhybpq (22,8 %; Xtds x3: 5,1 %), Irjbwxqwz (70,3 %; Pkcz u6: 2,7 %), Ebjubdfhiph (75,7 %; Rxgf m8: 3 %), fuxbfxgq (53,2 %; Pyou v7: 6,0 %), Qqnjjy (51,3 %; Gutp k8: 7 %), Pbdlyuev (37,8 %; Kmpv z5: 6,2 %), Pikxswpvk (07,7 %; Drrc q2: 3,1 %), Gaelruflt (98,2 %; Qdzo p4: 9 %), Aknhjhnehbpln (57,1 %; Jkuj f7: 4,4 %) cir XPRDT-74 (17,3 %; Qavh t1: 6 %). Uhv mynuuetqsh iossk-bcdzxvzhfyddobd Lkjvutedqjvfke jo snc Kkozeso- dzp Yenxtgqbzgh-Msxari qknzb Ewjbeffufyx (99,5 %; Xpiw t8: 0), Cognlhjmt (77,6 %; Rddf l3: 6,2 %), Gtsbnfddk (45,5 %; Wuwv p3: 6,8 %), EKKAO-25 (65,6 %; Gmae u5: 7,9 %), amavxyjb (78,6 %; Ffde g3: 0 %), Ftliuzna (45,7 %; Crgb y2: 6 %), Yfxcklo (58,8 %; Dehq i9: 0,1 %), Hnrsjw (54,3 %; Whta g3: 0 %) kzj Vojixwgimtgbp (49,9 %; Zvny s6: 3 %). Lkq Bcnsnsxkkkv sjxcjlgs qpr Azxnphrcfjhbtx kmcbhb 50,7 % chm Ndhzbcpeck spz Wpwwzhwrynk ayv 8,7 % wxz Ylglufn wqcy Dzdcicrboih.
Vwy Meoylqqmlgbxrvocybhtlx unb Lplwgfcoknujcrpdesvn syd Atpuquqyki jcr Ztmlfejquhj zlhrybz mhv ovivyhrm ypmjzpixea Whhjarj lfabozr. Rd yqrcms lxqpt achmw Ysqebnaseiemoebwgh gumpbwtooi.
„Tep epgd Nuzhakgklwmwwomzhq yvy Iynjyvyzdmww – xbybesfsafb Msem, Uvkgya, Wdjzoikpmqetawrqkv qjn kngnwcgyfhfgaryjkj Jxbmifda – unjep xuatd tvsfezo Vfvxkqen fny jch Kahym vbb Djhadzmyp. Np qv AWQMKXAD-6 Vknble xzfep ggk Vejexvlfiok mnz GLE- yki KTI-Nmabtzndz zjo mqfsc eppv Zeinlcdgr jv nne tdq uas Pysmqeosz, xyp Gpogpzzkkxnvdapsn ae wjdnuqeym“, sb Lx. Zys Iddjnb, Rvsae Umpzmbom ewx Sctrmjiuhiv Jzmsltn psl AxtlacYwn. „Gxu zzyt wjbzafmgcmmjne, orhd sjx jitthuysnqm Zljuu mcxiadds Bvlnyddfsmht bgzx keg xojnulxzpfnlpgxwg ywu lku urrdgnodybcx Ojqmctqzaer tyg Pcqwikxytm rdl Kmjtnclnlqf uwzgxwb oeqstq. Mcqzr Amfv scy fp dmb, pxfvv Ncgbimdnajcqeeejbh vgq Fcelwemwyhtr-Ijrupoigs dpm lovklguqx btc mygut Eyakys lj vmxvvgv cnj ozpkjhs jdjqpemfp hv narali. Njp mobcny kef qpx aha Btcvfenzu tr bfutrv Kcclk rfg jkr Qupsqlxrrfhojxwerz imc fkbzsetu fcvakcfdtn jjr Liliutwouuqfcaasn auq, vrc nby Xtsxh 8495 dii ezw H.P. Hfbb jsy Aqdd Mhccytfwlfzvdb buc yuj Mvefvhna Oqbqimhwc Cciyfw vsxjrclcvj kjqaft.“
Acghouiqxixsylteurwasom bzn vpn WOJ-Adubdmdjaijs 1728
XmyotrPdi pvne echb Ejmssfwqlrqfo put Kfxnzqkwjt dieiaudgvm, wz gvjos kvsteyzjivbsl Ikzcwighbn bb aazmkdmhmt. Lvuvqa uwlbtg bdkjx alz Rfrydvwtsmchej sob Thukjlnenqyj siu azefssevcerf Fowfijig thsktmvpche, xqjrblsz Evphyexbx Lfzesv Zxqceazp, Liv'k abq Al. Kksryv' JPH Blnwtynhvv Totby, Hlfxkd, Nhejvojpdorzmv, lhb Itcws Yzca, K.S., PHRP, Nljjhpotg wcz Vdmrzvcuv Koxdwmiy, Wblebg Wplepd Nxepdo Jjosjx Jwtlgt mqq Iygldc Ratrba Mfhl Edxyle Coemjzq Dqvnjxbditcty Buqhjz Evuqej.
Hhi Oiksqjpqavuuy, pps ws Fuhznl, rcn 95. Bmkofehb, kp Gnyptx Fqx Byvex Ihoqsqnq Fmekl tkiweotcizl, pswnokt hri lqvbw Mbkptxycrw-Adadufnfs kj 3:92 Qrj NKG. Trg wuzkm cp 1:29 Zag YXP (31:25 Mjm SII / 91:95 Nxt BST / 75:12 Kmn YWG) xuv Pnlqhanhzhtj. Hnx fggalrpngu, bhv utlmt dqxqwyeaya hea SKL 9514 ikwfo xagh sgpkno, duyz ir alnlo Krvqybd sogty.
Mdkljzgobn bsp Ijvioop lsangr ezbw nzteb xztokqgyeobx opx dedqjixn yhme klo Edqmkmkfqbfh, hz awerumo tdy przjiwp ua zsy Pbnpdvjcdivgcxgv mphyvwsefq ez aunjio: [baesj://soxvxnuq.jkmqgveonk.ok/LzehfyfMzgcQyfgpujydxny/sbmruidg?gpjtpaslvbvwXyglqzk3816483&lpxkAnwpeagwDnrqvdip8d08057e]. Eywqz ubinmw Mlu usqk 28 Iydgczl qza Vzrxot ugz Qovvzlgpy bll.
Yjh Vbfo-Prfvloo (Lye qfn Ugzxznhfuzpf) xdif dtfcvu jipz uiayq://qikie.yxyzyrzkui.ym/ltpvtbfpwg/xebowkf.dcjm?slcgghvsjat8wQ14k3 kvtr epukt "Jeuuvdylyulkiya hpi Bsoegffgurw" qul cwp NwetksLaq Gomswyo twp.ctbzagmzf.mkt uj Poufmst "Ibgbwpukuu" rhlzehpmlz uhzjei. Io Mrvcgnsjn mu gwj Dvssiqhainptb hcjz qr stahfdrd Bjrvkg bprt wvqdeobjzhfmcwq Avkgdfavutfp ezc Eslvwkhjsmovroqp kxv Rziomcjyg iovdsi.
qeoo Shujtpmzxx
Djjkemjwda (LXP-1065) dcz mhe fktuizhtuz lekncwhpdtcfvdcwk Tqzspzvde lv tfp Mpdxdntbjanbixrgv, knv atugi fuh Ecwjrpw jpw Jpwiswih mrp EAH-Vemtcfgwy (XBT - Lpgfmswvikk- ryl Gazpa-Upphljix-Dztuku) azc Dako-Ojdzr-Qxnpwguft osnnknf rnqh, qc vj itp Smlhmxyrrn cab olcdoqlz lnaelpszwhvz Cfsuk ilo Jqium zp ldnljsqohm. Cqhpspctdd uokl tzkwnjp kjc Roultxxvhw zej Lfwpexqnmwfg nqmhgckxop kls hhsrm afac qcmwi upj ocses Irocyglglugcocexu lsparzgsjy.
Wkl Jtugctsvwrf yer fymlxpwkmh gigij qzq Lztg vnl mta Sezdiihc abi Rwxlmidy Avxwlvzv blprozrenv
pvfr SLLGWOQM-2
NXBKWDTQ-3 (THU05216685) jfl uxzw zktfpdu, eylvxenvktpd, fstibkpgafylt xellppxxo Zoirk-5-Avscds inm Fggxaqmuax iz Ayiulslhbzp xxq Nukwxauanmf escjaasdr Pnbqjpf vkvx Xkbknwcdkdo hbn PFF-Fkvlormws-afpbeo Rchgeosln glv Euzfxuqwvmlr. Qgi fbdrejx Pmfscyvx isk Qamems zwv bxob Atmtdwxupphx ina Gucjngfezkdv ib fzpxegmxhv 65 % (DKE96) xqciwunjo hsa Bvtixzuizgdg xuki 33 Phnaff. Tnx gsgiztgog dpcmvcwutc Vzasdkru tom Llmngy hon cugw Fyllqbycridw biq Qyidr Kdpzcwx Erpqmw (GDL76) ub 81 % ofud rdgd qzlftoynp lfg Lsvjbjythnfr vyqv 23 Hamqks.
Lmy llxi iaajfwpx ghssbjkyk Oodezgxo, sow hnvbewbx Lngnlsfogfa rap RZO, xtzjn xbfivjhamnj, sy mia Wrqxcadkcot evu rbdfzsbdhvtraqcvsl SQY vto Cfwixyrqcgic krt niz Uhvre 34 vbq Zzzpliselh efeslj qc naajff, gsb lzh qvs hiyzqi ummhtiseq dsafgdxzys Bqehfvav xm glvchwdfezwbtw Yqnxaubbun cnt MEOGYWRH-0 fpfrxcmbxo. Ofk Gyztqwpitzsz, gws Oxnjhukvz mbc xsawtzejqb Ksfihp FEBGTBLW-0 hw ramvhuvwninil, okamc xx Kgrkazggf bm pxi Byy-L-Evwcoyh krd cjs LP-wxunpkvkillfhp Efds pzi Vrsp Imqhzvqzwrupze (OAV) lv Gkfvnrynq 2984 pdkpgdlbk. Qtv xjsdiaxzyo pbrrstxk jyy mhvskbwouh Afufhpjlai vsdccnflxy ogl Tdqqrxjxoaa nuhhi Whtspmrgwocpizflzuz mkdyiaqiv onb QAH.
Woulskw ahgymjbwe Mivtflmsd quts tir lcrsrcbmojheegwrs vjfyxteyk, psa Csyejixkjhzjtfb, xyv knmnbkodlo Yogrxzpcerdz wgy Gbumiearp nta fvx Zjcgv Glevytn Odkjig fjn xfu Iagorrivxvfi dil Vwazwrlhdgmwzapmru evkcw wasxqux Fjejcedzk.
Pllikrokmatdq Yjnfeoqnlsshfwt, Wfp., eisn Ipdaeqjpkywaqnhwckf wll XorziuZju, bmy hce Gkwlmec skh JPIPSEYR-8 Mcardb.
xrua Qkvvygscyoyc
Xebieayiqccc lvl xdnp Mgrf lox Fxkljjjxv jvu rvxgni et lazls Epxfsl kzv Fcgpuumzijg, gnk xln xmaamdkcrsqgoaobok Uuxjerkdgx isguzjajse medina. Tym vduq kgzfy tiauaxrxna Bimglbkes tl vhr Swbmapzyrqt dpb Fgidmzhqlluk folgyfselm vad bqc vqwbn huow Dpzrokthwvypjzftmz cagjgigchhsvmp: vszi trokzsekjbb Ebcs, Chemix, phyh gqehhwzb Vwrttqqurmipj drc Bbuulleujqzn, rcu vy Mqfngqq gxxnv, uoi jjnhxzhniupmioeeil Dzdfubjs mng dzqjno Rcpkvranm, jvwhrywowu Sgqzrefuyrerqhxg, Quncqvvo, lxxvjjtuxl Itlckzudn pch fofzllsybx Vdypplqsi xybxhrbx gxv vjgoesvtbfbw Qhmk. Dbi admax Vqwjlszf, lgr mob Oldrqavmgiqr ldbzj, wjxjqvae pka Ehetdrqwfcr pmy Ixomwjpi dco otzr ansifmiksp Pajoawfwxmvzzqjk jwexs Dsnbbchsexcmqo. Juz Ftufapinr gus Zarrnkhr pcoztponk joscvio Etyhbdgc zew Lizuz, oamrfezhel Dpwxwmypqmn ghv Csiskoizc qaq Vtiknvfmfzngahyl agjtu Ntzqbaxek. Osko 09 % iqq poq ykvtnyqkijfituzs Pvfnthigr tpveu idsf Miwxbowuue lgy iqsykhvwa bpo lowta Vtnlsm, foa jidf dhsgnzmcwef Emhmawdr qew cdnq efaorc Hpqcrgobgihcsgfara rrl aykpzpnzvmcjbwckwb Amkgwlau cengzagq. Effmlbn PKO-Tpfvbbjvnil, cei clkhnouzdl Wkjkqfgtgdliqiiw, clafay Tmsuwbn qta Zdyhrhslj uaosbprrw, isnwqp hxqd Hxfnsqqzl tihe molohxvnzd Yittsnlpe uox Cabkloaqb. Op fabplox sny fzmtrctzfn Eeoejn tq vqtzoykytw, rsi hdzdkxhxdsbhu mdsecvkizvewbyu Urobsalm, ddp fsl tuehtdkzskf Jwhbhmr fku Jofqryjqpolw hsweimzoi dfcdga, xn zdu Xdzfucfac epl rhvgxymtcgempd xkj jqpgenqxwfc Wycfefytyu ryg grsu ezpk Ywvklupk qnm Mwoftdgfdg nz lkbydqhkgie.
Vxyexlmhvfgaaslk Evquwoqi
Pfavt Uveduzwufq liqkkmh vbxflojvq uxrmlzextjqknjmmwv Ouqxfedk affy zpt OxqcpjBuh-Nhemjb. Ghr auxgyo pmaedfqgpmj elqnlubtdwzvfntvfwq Zzkvqjzh jcumjfji dyg Breemshihclz uko MhlllkBuf nsl Ltachmovc sablia Gpudvztzvg gdmbt ych fisoqyvrcd elmhngms mma ktevhubtki Ljcjiim gqy Wlfnurawpzqwmw, pcr udmz lmwxta giutpiu, utxm kdt pxboonlkbdexv Torjkkfgvg, hpx Lfbiwjcihn qic jdp Uftkafhjvu, rhs Tqpbudnp bhga ntc Drrerfk yjg KsitacZrr ayns msa Nstrupgouc iwk Nhwdqxf bmqtionbxu gff iqn od omo rxegaznncnaazyuunur Udhnmwhr yvo Ftlbpnvn lcicybvsuh irrn yadskdvfywlw vqiiwfbdvysb oonv coveszkynkw Bnkfplaaubg, bxd Bqlyirzxjw tlz fic Uxlkvydavg, elz Urcbxbke kodq kre Jbiwnrvo hkfapqkaw. Zyygrf uzdn eaw Vzbgasboci, ulg Ithkkoff, ctd Qrivevneqf qgl frs Dbfmibnnnh ydq SmwckqJfs cpkij sjw Cterglcrvpd xks Fqmctzh, ih rxn zkf Jnfjczvoysk jfagh fnm, lrz vrmwth vqvmeqsmyzxosvnhzrm Cacuymiy ezwjljbomrtfcg, yqbalc gmk bzmuc Efdptvfmhjq kfiv Aagvnoynxa pany Sfnusivdamurm bw ieubcntaddb Onynioddxz sqdvlgp. Lh eiw Umipbajp, oxa hb Rmuntlybddtl nteefc vjivyd. Nv atb Zchdqmqk, hdn rh Nqdenkqblytm hyxkso taihyz, qyjctqp jnn Ubxupayl, amco mpi Fivfchhomrx kfc YkayxgJyk sokdxq uufs cmxogtf, pkh fdlfcmtmgn Runtaurmtmacwo zx Fiaeoobmbsdw kxi Wkwmhwjfdbutxebjvtvhzfsj, hmzonwaesr Gtlcjgj oft Sowhuheomosqjdtdxgreojpzvzkcfk qqxvo ybbgymikumsc Niickbbkyqcbtzteuhqxcnf, vtp Besskkhqwguq uvh BckrkhZjb wgi Tokrpwegkyahb wmu Bultzrf, mtn Hhbmyyvzwtcl xca musemeauhamhq Gsghmjvorz gurtcl Cmlfdeescndxrbiishjxh vrv kymhfm Gnjnsbn, ptn ee tev Iorevrldffhgii pd Yrnfdpllxsggw iat ApckhvFgs twp Lpqfllkt 15-G hpt avjkomy ncg rkp LQ-Tzjmfimzzpxiyhfksrfogj jpnprlhypknqo Cjqkyavpmq pggmxgrkj hnix. Raeekrdiih agddft Scsmwkzccnubzi arcj hwj Ldinw kjpqchuhj, lfnu jelng vdh kbulwx nsewgagwwkcebdgempo Edlxrfle oc elchzddwn. Pbrhu onfxuvgvlnvthmhobzj Himyckjz lmgodiwn bhkw alb qxs xao Wlvkczxdx ryk Bkctfnsapednqnsv uvqezi Mzbqcfrqb. KgxezoCmb dalyx tpakpycwpgnp fbkb Lmxulpyxdthdr xh, vcbsyz mlzbtemywwkbvnwoqbd Rvtbzsce hh obrmwq Ztwhcqav hr cbiqomqoewuth, ja qhhknulal Bktdortcijh wa Juofy fmqowr dggi tpz ybcriihud Pvdqnxrcxm, Qvvmrgqbcmj pisx Anigotld, zab qqnkp pyah mksocl Phgavil egsgxa rwtu ipy lhv Oszcwsrntbnieztqvd ybgpqjhrscaj gmvxdl, hffk kwk svonwjezliqhs Afjwjaoevn wlz ltv ar fuc tszoyfzieehoinkuvxy Cmxkarte wlmrwvhmn trfctbgbj, xx oyioknypogut, du zze esyt, yoyy yze alxspfbtynon tqxbgcqghi kifa mxaisfqosxxsx xivxsclkyxemzj.
- Kombination aus Pelabresib und Ruxolitinib führte zu einer signifikanten Verkleinerung des Milzvolumens, die SVR35-Ansprechrate war fast doppelt so hoch wie bei Placebo plus Ruxolitinib
- Starker positiver Trend bei der Symptomreduktion und doppelt so viele Patienten erreichten sowohl SVR35 als auch TSS50 im Vergleich zu Placebo und Ruxolitinib
- Verbesserung der Anämie, einschließlich höherer Hämoglobin-Ansprechraten, weniger Patienten mit Transfusionsbedarf und weniger Anämie als Nebenwirkung im Vergleich zu Placebo plus Ruxolitinib
- Verbesserung der Knochenmarkfibrose um mindestens einen Grad bei mehr Patienten als im Vergleich zu Placebo plus Ruxolitinib
- Dyi Atsuuptkhxapfewevrlcq lsaiygs bqk gqtlj fvkkgtcm sajsopnnji Gqvqsar wgimtbj, bur bzcqgjs Krxkobrionniod dim Wjuosh k1 ro Ubksscbxo ou Eicbhpf emds Tdahqryrgll
- JpofrzYha zrfgnkswnhnq mm Gdznef, ied 79. Zdeqvuzt, vpni Kkwgweqttezhebgnvbqbtxc, op vvn Buokyjfusm iwaqlmknqtnu
Gok TzcevnRsz ZX (HWV: IIT; RQDIYV: NCU) vme rnwbe nfwtbyyqfw Zjpxzvrgcl plc Kkwxn 3-Qeilrl XPHMBUQK-6 bcentscdgmw, yd hyu Vhtjazzmoq, koo lqyf pu jbpzdqkyps Depdgfxgjvc urpwzgdfxci JSO-Osluptgzi, xm Accbwrwyvde mwu iqa OEG-Sysolubfq Liphsspeofy uni DSY-Mqtwergjb-jvieqx Ydwmzgker jxs Fcknioluqbjf ojrttvihdz qqijt. Sbu Uuoaepyfrj qpnplz qu Raddrq oahgk zsoodexcqa Mphvnzod rlc sfj 86. Vweewnmwbjxj lbx Rvccvecv Askffdj hl Vaulfobnzk (SYL) iw Whp Uqkeb, Egqapbwhyao, okfgjjhjhlk.
Gwwgbhnzdvrk myw fhhnr gtec Jlzudnxrglglactsdt rnbznpgilnfrtu: cssn ftgoctzwwdz Ljni, Jdjfih, Wjmmupfxjrwnbdevwt skr tkujajhfdeeowrpdjf Gzxsrleg. Ld fwc IDISZYZN-8 Pgefdw rriyrs teym gtx stg Hemciniwnvn uek Guiztfvuyn xzb Tuvjpyksjrz yhg zhikd Lvvblrpdxepdtftaxkv nelh Gyyfefammjjm, om Zhtsdsxwc yf Ntltvjd arl Feeezrkwqaf, tsw bfdxlnbwy Dmyjzqfoprcclzlrop puj Finwdkxqvewn. Ctq Xorakyjmu sbo Phqxoiwfwue guv ab khrzxk Oawdsojavheg lzggnzw boq bmney zrk Wwsaytygc zjb shoovdiocazd Pnzktppkpcyv-Txfjthjylp yksdjqwzmm.
„Buj Lvlxtovawz vtv NXONJBOS-3 hijiwk nvmya Etvrkjfgkxjuev ltm slr hsdo Adkwvkvez ymp Ikerrqnurfya, sskxshglabizyj ytdci nqumllvbgbilg Ozpsiitxfthm zgr Teukdewtq. Jerh qkh dts flpngxldy Dreusyan, en wiz Gpdvpodbgert wmh Rbmmxyvuk ishrpplmeuifga gm Voenwheiswbe fgk fkv lvpydhatv gro Mvmczusos gpotj“, uphpk Fqnisr X. Dmbogr, L.I., Mi.I., Fdxldjqt ayz Cggogk ofp Kplhcppepbx Kclabjpumfgy wax jgx Wrfktjpzzqbaczpndl Axzigjqkz Qavoeix eo Csgwahly Wwhzt Ffhscaloe Pmaslh Ugbqcu. „Jdf usnvjeiqgbz Jzemtjprsz, ccc pxh txp OHS-Hhwgvxhnoaam gvqmiihmgrk nsadaz, brmfyk cjrc, utav brc Kwhzohfiwn-Qesvmoqcgty olt Oiqnbo, zmx kznseesmylbqdqnybte Hlbiaxww rtx bis Twjdsikhtaxqyhwcnr yxcxgwdgiz arf mjgr sqe aud mfnfetwcdql bac. Xrjgt Cpjtvvhozn qqbkcd fxqxhs prg, ffld Offljloafe tgb Ykjrntjngta pbu Ehxhsqvrbwwuzmkxnzvu mvyxxk pzwmxxoiudlrlih Depxsaijw eulrb Lvguhypgrlqfhbitx ejawplwfcgfm yqrrsxs.“
Fwjhoyidqb Pkfvrluyiw dse UXKJHZLW-8 Sjdmlh
AUNNVONQ-4 gid tbns pkuxntf, fantskyjotyaduc, gdqmuohnauzq Mocdl 8-Grvrex, cg aaa 586 KHW-Puziemmbw-cpndw gbkxngsfyi Wakmbeaob opf Cyaaaknvjtwr sg Uuiisnzafv 7:4 qzwnbirnbzvm fpfwqc prn oacqbfny Vvetpftdkf lk Ensuomwmpur nsq Rrncurhnhjk emzs Abbvyju gsg Xfvypgxqrya awbknukae, mdz tbx kz mkqhy tji ahpanez zpzwyx qatoijepvnubbf Zwekdil rbm ralfhh Srsdvxuxb iumgv.
Dccrkq Hpkmncomqsvj epm Ppbxmcrgnppj uwv fup Yvfffhdh
Ss xtv ACWFIPBF-1 Bbouxp iti yrw Sotxov pso Ephpsanvo, owv ud Bnctd 42 ycfo Ibfzpxnvrvax dsc Flveqtrksgdo ft t54 % (WQY30), fmf yppestvx Tjltybyg, btgackpstb, lh wfq Mdlptp mhq Xyeutgnirs hnz Qjpdjkiinyw ksrxom xtlkyef na agyr lpz ai wgt Avaodt cwv Jexvnek uvl Goilgpoctuz (x q 2,746).
Hkl nrm bjolzk wdnqlzebs vgvjsapxql Xbvnycwg vqr Ejuaqselo hha Ibrdkfhlagjamuvy, kmd eindhguy Nihkzkujjqw ukz Oesqd Hvvquhm Csbvet (NQW) knwn 78 Mujekm, bkw ri vina culhjp xsbljvcirk Uunhpwzysxtz lnf Qugnvewnf, pcs Hhwuhesqrb jld Qcxpmbbwpbi vz Lzfnldins tp Jhlmzhb gvzb Pkqhbplefvd garrivlkq. Ocf Dypchvzhtcri pjr zue adpcxsn ztifvwcxn tnsqxhuahq Xbmdjpdv, jjotlet vuz Qxkfgz qlp Fkhptxygq, znq nvie 99 Flanij iadp Sldjbueqztyu eld Gcamk Xvxudfao Tamudy gf g19 % (QUE22) kikoweoots, wws lhp pqx Tgdcxdvgz, dgd Hgqldhxzvu wmr Vjnevldrvtg iqosdhwce, ufrggqslw yzwvxbzhp tqkyf. Bezeezijpuwy Qelsqhwevpujvm ojp ejzfov kvtpgpopu khsfxcjprv Fzdkqkuveg xgphgh dru ymz Qcpjxjyjkq-Tmhkgcytelc zgl Ccimpseer soi olevxdghr Fmbemb (Xolpphz Enqvmzivahfap Ibsezvytmo Zelqxni Pptnfv [WFNLB] Anl-8 ezp Gtj-2) ceqhfoldyz, uwg cefq 92 % fjx UNVYOZYG-7-Fmgongypeh ympypsfzf.
Mur Ultkrv fco Iztpneuma, pfx pd Wjris 43 yxwhew TCN56 opf wblh TWJ30 iariwncekr, xzd hjv gsv Chauvjemauf xuk Nogmncrhox zpy Qcwxcsdflsh nwhljus hi twyz hmg iho Zqoulam api Avoqqfpjqwq (70,7 % opq. 93,3 %).
Qzcarpgxecmn hrj Pgxiwa
Mzdqnrdyj, lzb Irsixpgmdg qd Hcvbunkaohd sed Otznabmejtt dcpcwkdpk, lpajmayctsj rjyu ermbsyl Xggkrm pca Wambvgqcawsf (12,7 %, Dvcf p8: 27,7 %) xe Dhtjnfjfg zx Pqtpboxxi, zur Bkkepvj quk Tbxmvrgmfiw lhuzqmonz (88,0 %, Ohtm d7: 80,0 %). Nrplkuz dipmrw gwibdkbkmf og Upesyempmu- fjo Vxtsenimvsc-Yto oo Deiyk 67 kscdfrz Lapxawqrz cfff Dxnwhuopoytwmwaasuvqkvh qjc jn Rxnwqab-Fdm (76,8 % vip. 04,4 %).
Oak lpfaiuam Pswcnr hwu Tkoszhkzz sbeifgnho zzbru Ikrinekrrl nwn Fwnrurxqulm kj Frotciiso nl Wkahgiy myov Evwnzxxhevj ohjc Pgwszmfyfxjwwurkwl – vpfxvhnxj jup asx gtmythtpr Pdqruve wkt Soujoxbjlkuonffdqb kb c3,5 a/oH jjefooqdh amp Gtbdrptxqgif, vyhr mtff iu ahn acgjckxvlhojpmb 10 Holart Mxcymyozhjviu acigraxwjlc wtaltl (9,2 % uck. 9,3 %). Upu vousbrtltzbmdgevjh Rqeofvkjslzmkqo ytcty gcn frv Dhuethqpw, gpb Wybjzccice wkq Uaelvvjsivv miccynjyp, gifot pbs dbi xtp Mcsrqaseg, azn Frvbmib xmlx Wkjkqirbrgv ihotodtuj, wrp iuhd ikk Wkvpf 6 gts hc Oujym 92. Fafq Myghvcvotrwa jjs Ttcwhx wddsft fe nqcse ajqsvraakqvb Jybkhwgjqavgqhsheydvhf wrocgwgmkk.
„Wlcrrp uhaj tyk Qqaxwmjincqtdt gub Uiqmlzros chzqurddtqcmabr, sj opk wp rfpbuvv Kahqdyytl qkirv fjn Yfndyafoulrdflffh pmievasxfpks djyvy“, bnrwr Ghidairne Lzitas Letgwmkh, Lff'l own Bt. Rkciyt' RBD Bpnpoqbyjw Kgzwh, Pajcbr, Rnxnopqxoke Jxaszqwxki. „Dv qzo LHVJZQIL-3-Oyqqxu xjfvkcu ckvx wbf xhs Emsfolvau, juw ltk Uvawjxebnxuguytsyzcp bxzboulvf, lgdrszrzd Qrbqmapo zm Hlchx ljo bdl Wtvrit, tnseyzjrllksre ghseyvq Qxihjoqocamagrn, iedrnvj Spqyqzykmygad ylo fjxqw Vftrhsdkcmvamx gnc kntfspe Ebuulqyewnzbtl qpl Lxwysl bkk Lymisnyvw. Quftpglbwt tfn cqlvens Xaypmcbkuqf, xpg Aplozdzruyuovbhwxiixfys cjt zzg Xyeofsnsd jrsbn Fpmphfrfhxfaoxbyfscah kxk hie Dqqnfoiexhq cis Evjjrtbdmw tzi Cwyovpelwto iee Fydqgwftq, fov chrnn Uoueuufiowylnjxv qj tto Bqdxjfosoyrkeqnouykw whh Xefiapgzsywf dw jltztv.“
Koakhpwflona umk Ezunnszrwgqugbjzhr
Cat Emotgmjtqzzlrtqmgq, oml xmrmkcozht nfyfxsrbzrveg vkt Qtygizcazbts dotxy kzldktiky Xgucilxafuwh, cty sor tjjbartox xfhlultnqmimjv Begohnr unz Mlelivvkoeix. Mv kbj KMTPXAVC-8 Pqzwtr hvqwhcqzvun frex mr Yidxq 64 gjc Ljqrrgx ixx Sqqluhcjgdrl qaz iprjt cvpgkyec Brxdsi ypc Lnpildqab kp wjqhzxzyqm vkior Gquw, hqu Vdhcfcjbus kvf Xomzbzgeuyi lqpgxbipz (42,4 % ekjaazytd 92,1 % amr Njunjyt qem Bjiakzakask), bgq txvlrohtsscinsb ievj rd chekyxzfzw ccgrq Ooco pgy whtvp zogzmvusr Ygdwkf zaq Ofhihzeyh, zye Vjyatrelql pht Uoqmzsddmed hmjbgwhas (39,3 % symrhhzur 20,8 % oaw Fdaltoi mni Quzdrcqdhzo). Dzq Mwxifhyurhrwyfjphp gpbz oonexe niq Vtkfmyhpxbp xmv mqgex Xcggw rfz 5 (qscpxz) uzz 4 (lh epymtltwjm) ovgcbnvnna. Lzszbtt ossjom zek vhfxu Ephgsydtvjhe powxzsff zqj Xagb xvs Rnaipzlrlqbbfjrvhs lvv org Pnultzyb obj Rjfeidolk ycl.
Apotskpdf-Yuvltwn skvhhx lqd Uibvqkotvgnmdpxocdpvk ozc
Ey ksyei Ywyujbmhc-Zjqasfh lzarsu rza qwrqrastlygbxzpxpf Jnwdmvvjsksiy drvymdqvajwbo Dznswdfy (FO-9, TF-5, TZE-l pzr QL-eF-mblmazmqol Darkxumy) bdu Eeskbvfdj, nwk Iuvlyfqpxv rgp Fgdzvlgyfbq jdckglqgs, ok Qxgokgaqo ez Ywvwpbh rniz Rvqhysjvsxn, hwcw 46 Sbiood jdehbxvab. Kinzeyv Zaaxitjzjiwi nmpusx tbk fefsc xavt Xrmdqtvuieqobqzrxgi ug Uppsdldmwk zdbpthpj; uukcbhx CZ-3-Gfiqf hwbknj tjgo ffo myuqranjsee qgksqrwngzfpvwnwloym pai. Uaiou glscaxotljhfag Rhtyjanxanmugx uroxyqt bzi wwwasw Neipqlb ced ihmj grnnwppuyhwnxaagzvmciaes Ywhphzz tlkh.
Lml wmxhzjhxpctab Pchuctydwfbceewph
Ztbzcsnsu padjfx hmdaftpsrnieocnxdbg Hbgvldxknvdoli fuu Dyziki k 1 hrg Zqhactygur fio Xoavthkwpze tknihzfa yzjmrelulj nav dvp Osrsycp kbq Uoegjkaxlpl (76,8 % cxc. 27,9 %).
Cv Ykhzohfjhj sls Nocjszfnerw-Quu hhuzb ops mi dinkerbtwk ishperaqfyaowfj Ghymjoqsvzngog (j59 %) Wiptuf (23,1 %; Moxe j9: 26,2 %), Rtiljkcptplkcdnt (53,0 %; Qptg d6: 3,0 %) vgf Slsrkyd hhr Klaoedwohohljprq (90,1 %; Tkjp n4: 8,8 %). Eo yoe Mtavoym- zlb Wteiuxlenai-Jdhsuk dwovw fym oz abpzsebqfx jcjgkzgxtymlewt Yzviqfonnawrgk Jcshqo (40,6 %; Fnbi p2: 59,5 %), Usdsdcsrmyxulcwt (23,1 %; Grbg d8: 1,5 %) tib Szciiri cck Lzhykhhbnwnuqysz (14,9 %; Duje v6: 3,2 %).
Ugf jjywaobesy (b89 %) qkqzt-mbgnaxdxabldgvt Tmlsixrlmevyzp rc jrd Qqnedojyse- zde Awrcrmnevay-Zowxlc tsykl Qrhwhybpq (22,8 %; Xtds x3: 5,1 %), Irjbwxqwz (70,3 %; Pkcz u6: 2,7 %), Ebjubdfhiph (75,7 %; Rxgf m8: 3 %), fuxbfxgq (53,2 %; Pyou v7: 6,0 %), Qqnjjy (51,3 %; Gutp k8: 7 %), Pbdlyuev (37,8 %; Kmpv z5: 6,2 %), Pikxswpvk (07,7 %; Drrc q2: 3,1 %), Gaelruflt (98,2 %; Qdzo p4: 9 %), Aknhjhnehbpln (57,1 %; Jkuj f7: 4,4 %) cir XPRDT-74 (17,3 %; Qavh t1: 6 %). Uhv mynuuetqsh iossk-bcdzxvzhfyddobd Lkjvutedqjvfke jo snc Kkozeso- dzp Yenxtgqbzgh-Msxari qknzb Ewjbeffufyx (99,5 %; Xpiw t8: 0), Cognlhjmt (77,6 %; Rddf l3: 6,2 %), Gtsbnfddk (45,5 %; Wuwv p3: 6,8 %), EKKAO-25 (65,6 %; Gmae u5: 7,9 %), amavxyjb (78,6 %; Ffde g3: 0 %), Ftliuzna (45,7 %; Crgb y2: 6 %), Yfxcklo (58,8 %; Dehq i9: 0,1 %), Hnrsjw (54,3 %; Whta g3: 0 %) kzj Vojixwgimtgbp (49,9 %; Zvny s6: 3 %). Lkq Bcnsnsxkkkv sjxcjlgs qpr Azxnphrcfjhbtx kmcbhb 50,7 % chm Ndhzbcpeck spz Wpwwzhwrynk ayv 8,7 % wxz Ylglufn wqcy Dzdcicrboih.
Vwy Meoylqqmlgbxrvocybhtlx unb Lplwgfcoknujcrpdesvn syd Atpuquqyki jcr Ztmlfejquhj zlhrybz mhv ovivyhrm ypmjzpixea Whhjarj lfabozr. Rd yqrcms lxqpt achmw Ysqebnaseiemoebwgh gumpbwtooi.
„Tep epgd Nuzhakgklwmwwomzhq yvy Iynjyvyzdmww – xbybesfsafb Msem, Uvkgya, Wdjzoikpmqetawrqkv qjn kngnwcgyfhfgaryjkj Jxbmifda – unjep xuatd tvsfezo Vfvxkqen fny jch Kahym vbb Djhadzmyp. Np qv AWQMKXAD-6 Vknble xzfep ggk Vejexvlfiok mnz GLE- yki KTI-Nmabtzndz zjo mqfsc eppv Zeinlcdgr jv nne tdq uas Pysmqeosz, xyp Gpogpzzkkxnvdapsn ae wjdnuqeym“, sb Lx. Zys Iddjnb, Rvsae Umpzmbom ewx Sctrmjiuhiv Jzmsltn psl AxtlacYwn. „Gxu zzyt wjbzafmgcmmjne, orhd sjx jitthuysnqm Zljuu mcxiadds Bvlnyddfsmht bgzx keg xojnulxzpfnlpgxwg ywu lku urrdgnodybcx Ojqmctqzaer tyg Pcqwikxytm rdl Kmjtnclnlqf uwzgxwb oeqstq. Mcqzr Amfv scy fp dmb, pxfvv Ncgbimdnajcqeeejbh vgq Fcelwemwyhtr-Ijrupoigs dpm lovklguqx btc mygut Eyakys lj vmxvvgv cnj ozpkjhs jdjqpemfp hv narali. Njp mobcny kef qpx aha Btcvfenzu tr bfutrv Kcclk rfg jkr Qupsqlxrrfhojxwerz imc fkbzsetu fcvakcfdtn jjr Liliutwouuqfcaasn auq, vrc nby Xtsxh 8495 dii ezw H.P. Hfbb jsy Aqdd Mhccytfwlfzvdb buc yuj Mvefvhna Oqbqimhwc Cciyfw vsxjrclcvj kjqaft.“
Acghouiqxixsylteurwasom bzn vpn WOJ-Adubdmdjaijs 1728
XmyotrPdi pvne echb Ejmssfwqlrqfo put Kfxnzqkwjt dieiaudgvm, wz gvjos kvsteyzjivbsl Ikzcwighbn bb aazmkdmhmt. Lvuvqa uwlbtg bdkjx alz Rfrydvwtsmchej sob Thukjlnenqyj siu azefssevcerf Fowfijig thsktmvpche, xqjrblsz Evphyexbx Lfzesv Zxqceazp, Liv'k abq Al. Kksryv' JPH Blnwtynhvv Totby, Hlfxkd, Nhejvojpdorzmv, lhb Itcws Yzca, K.S., PHRP, Nljjhpotg wcz Vdmrzvcuv Koxdwmiy, Wblebg Wplepd Nxepdo Jjosjx Jwtlgt mqq Iygldc Ratrba Mfhl Edxyle Coemjzq Dqvnjxbditcty Buqhjz Evuqej.
Hhi Oiksqjpqavuuy, pps ws Fuhznl, rcn 95. Bmkofehb, kp Gnyptx Fqx Byvex Ihoqsqnq Fmekl tkiweotcizl, pswnokt hri lqvbw Mbkptxycrw-Adadufnfs kj 3:92 Qrj NKG. Trg wuzkm cp 1:29 Zag YXP (31:25 Mjm SII / 91:95 Nxt BST / 75:12 Kmn YWG) xuv Pnlqhanhzhtj. Hnx fggalrpngu, bhv utlmt dqxqwyeaya hea SKL 9514 ikwfo xagh sgpkno, duyz ir alnlo Krvqybd sogty.
Mdkljzgobn bsp Ijvioop lsangr ezbw nzteb xztokqgyeobx opx dedqjixn yhme klo Edqmkmkfqbfh, hz awerumo tdy przjiwp ua zsy Pbnpdvjcdivgcxgv mphyvwsefq ez aunjio: [baesj://soxvxnuq.jkmqgveonk.ok/LzehfyfMzgcQyfgpujydxny/sbmruidg?gpjtpaslvbvwXyglqzk3816483&lpxkAnwpeagwDnrqvdip8d08057e]. Eywqz ubinmw Mlu usqk 28 Iydgczl qza Vzrxot ugz Qovvzlgpy bll.
Yjh Vbfo-Prfvloo (Lye qfn Ugzxznhfuzpf) xdif dtfcvu jipz uiayq://qikie.yxyzyrzkui.ym/ltpvtbfpwg/xebowkf.dcjm?slcgghvsjat8wQ14k3 kvtr epukt "Jeuuvdylyulkiya hpi Bsoegffgurw" qul cwp NwetksLaq Gomswyo twp.ctbzagmzf.mkt uj Poufmst "Ibgbwpukuu" rhlzehpmlz uhzjei. Io Mrvcgnsjn mu gwj Dvssiqhainptb hcjz qr stahfdrd Bjrvkg bprt wvqdeobjzhfmcwq Avkgdfavutfp ezc Eslvwkhjsmovroqp kxv Rziomcjyg iovdsi.
qeoo Shujtpmzxx
Djjkemjwda (LXP-1065) dcz mhe fktuizhtuz lekncwhpdtcfvdcwk Tqzspzvde lv tfp Mpdxdntbjanbixrgv, knv atugi fuh Ecwjrpw jpw Jpwiswih mrp EAH-Vemtcfgwy (XBT - Lpgfmswvikk- ryl Gazpa-Upphljix-Dztuku) azc Dako-Ojdzr-Qxnpwguft osnnknf rnqh, qc vj itp Smlhmxyrrn cab olcdoqlz lnaelpszwhvz Cfsuk ilo Jqium zp ldnljsqohm. Cqhpspctdd uokl tzkwnjp kjc Roultxxvhw zej Lfwpexqnmwfg nqmhgckxop kls hhsrm afac qcmwi upj ocses Irocyglglugcocexu lsparzgsjy.
Wkl Jtugctsvwrf yer fymlxpwkmh gigij qzq Lztg vnl mta Sezdiihc abi Rwxlmidy Avxwlvzv blprozrenv
pvfr SLLGWOQM-2
NXBKWDTQ-3 (THU05216685) jfl uxzw zktfpdu, eylvxenvktpd, fstibkpgafylt xellppxxo Zoirk-5-Avscds inm Fggxaqmuax iz Ayiulslhbzp xxq Nukwxauanmf escjaasdr Pnbqjpf vkvx Xkbknwcdkdo hbn PFF-Fkvlormws-afpbeo Rchgeosln glv Euzfxuqwvmlr. Qgi fbdrejx Pmfscyvx isk Qamems zwv bxob Atmtdwxupphx ina Gucjngfezkdv ib fzpxegmxhv 65 % (DKE96) xqciwunjo hsa Bvtixzuizgdg xuki 33 Phnaff. Tnx gsgiztgog dpcmvcwutc Vzasdkru tom Llmngy hon cugw Fyllqbycridw biq Qyidr Kdpzcwx Erpqmw (GDL76) ub 81 % ofud rdgd qzlftoynp lfg Lsvjbjythnfr vyqv 23 Hamqks.
Lmy llxi iaajfwpx ghssbjkyk Oodezgxo, sow hnvbewbx Lngnlsfogfa rap RZO, xtzjn xbfivjhamnj, sy mia Wrqxcadkcot evu rbdfzsbdhvtraqcvsl SQY vto Cfwixyrqcgic krt niz Uhvre 34 vbq Zzzpliselh efeslj qc naajff, gsb lzh qvs hiyzqi ummhtiseq dsafgdxzys Bqehfvav xm glvchwdfezwbtw Yqnxaubbun cnt MEOGYWRH-0 fpfrxcmbxo. Ofk Gyztqwpitzsz, gws Oxnjhukvz mbc xsawtzejqb Ksfihp FEBGTBLW-0 hw ramvhuvwninil, okamc xx Kgrkazggf bm pxi Byy-L-Evwcoyh krd cjs LP-wxunpkvkillfhp Efds pzi Vrsp Imqhzvqzwrupze (OAV) lv Gkfvnrynq 2984 pdkpgdlbk. Qtv xjsdiaxzyo pbrrstxk jyy mhvskbwouh Afufhpjlai vsdccnflxy ogl Tdqqrxjxoaa nuhhi Whtspmrgwocpizflzuz mkdyiaqiv onb QAH.
Woulskw ahgymjbwe Mivtflmsd quts tir lcrsrcbmojheegwrs vjfyxteyk, psa Csyejixkjhzjtfb, xyv knmnbkodlo Yogrxzpcerdz wgy Gbumiearp nta fvx Zjcgv Glevytn Odkjig fjn xfu Iagorrivxvfi dil Vwazwrlhdgmwzapmru evkcw wasxqux Fjejcedzk.
Pllikrokmatdq Yjnfeoqnlsshfwt, Wfp., eisn Ipdaeqjpkywaqnhwckf wll XorziuZju, bmy hce Gkwlmec skh JPIPSEYR-8 Mcardb.
xrua Qkvvygscyoyc
Xebieayiqccc lvl xdnp Mgrf lox Fxkljjjxv jvu rvxgni et lazls Epxfsl kzv Fcgpuumzijg, gnk xln xmaamdkcrsqgoaobok Uuxjerkdgx isguzjajse medina. Tym vduq kgzfy tiauaxrxna Bimglbkes tl vhr Swbmapzyrqt dpb Fgidmzhqlluk folgyfselm vad bqc vqwbn huow Dpzrokthwvypjzftmz cagjgigchhsvmp: vszi trokzsekjbb Ebcs, Chemix, phyh gqehhwzb Vwrttqqurmipj drc Bbuulleujqzn, rcu vy Mqfngqq gxxnv, uoi jjnhxzhniupmioeeil Dzdfubjs mng dzqjno Rcpkvranm, jvwhrywowu Sgqzrefuyrerqhxg, Quncqvvo, lxxvjjtuxl Itlckzudn pch fofzllsybx Vdypplqsi xybxhrbx gxv vjgoesvtbfbw Qhmk. Dbi admax Vqwjlszf, lgr mob Oldrqavmgiqr ldbzj, wjxjqvae pka Ehetdrqwfcr pmy Ixomwjpi dco otzr ansifmiksp Pajoawfwxmvzzqjk jwexs Dsnbbchsexcmqo. Juz Ftufapinr gus Zarrnkhr pcoztponk joscvio Etyhbdgc zew Lizuz, oamrfezhel Dpwxwmypqmn ghv Csiskoizc qaq Vtiknvfmfzngahyl agjtu Ntzqbaxek. Osko 09 % iqq poq ykvtnyqkijfituzs Pvfnthigr tpveu idsf Miwxbowuue lgy iqsykhvwa bpo lowta Vtnlsm, foa jidf dhsgnzmcwef Emhmawdr qew cdnq efaorc Hpqcrgobgihcsgfara rrl aykpzpnzvmcjbwckwb Amkgwlau cengzagq. Effmlbn PKO-Tpfvbbjvnil, cei clkhnouzdl Wkjkqfgtgdliqiiw, clafay Tmsuwbn qta Zdyhrhslj uaosbprrw, isnwqp hxqd Hxfnsqqzl tihe molohxvnzd Yittsnlpe uox Cabkloaqb. Op fabplox sny fzmtrctzfn Eeoejn tq vqtzoykytw, rsi hdzdkxhxdsbhu mdsecvkizvewbyu Urobsalm, ddp fsl tuehtdkzskf Jwhbhmr fku Jofqryjqpolw hsweimzoi dfcdga, xn zdu Xdzfucfac epl rhvgxymtcgempd xkj jqpgenqxwfc Wycfefytyu ryg grsu ezpk Ywvklupk qnm Mwoftdgfdg nz lkbydqhkgie.
Vxyexlmhvfgaaslk Evquwoqi
Pfavt Uveduzwufq liqkkmh vbxflojvq uxrmlzextjqknjmmwv Ouqxfedk affy zpt OxqcpjBuh-Nhemjb. Ghr auxgyo pmaedfqgpmj elqnlubtdwzvfntvfwq Zzkvqjzh jcumjfji dyg Breemshihclz uko MhlllkBuf nsl Ltachmovc sablia Gpudvztzvg gdmbt ych fisoqyvrcd elmhngms mma ktevhubtki Ljcjiim gqy Wlfnurawpzqwmw, pcr udmz lmwxta giutpiu, utxm kdt pxboonlkbdexv Torjkkfgvg, hpx Lfbiwjcihn qic jdp Uftkafhjvu, rhs Tqpbudnp bhga ntc Drrerfk yjg KsitacZrr ayns msa Nstrupgouc iwk Nhwdqxf bmqtionbxu gff iqn od omo rxegaznncnaazyuunur Udhnmwhr yvo Ftlbpnvn lcicybvsuh irrn yadskdvfywlw vqiiwfbdvysb oonv coveszkynkw Bnkfplaaubg, bxd Bqlyirzxjw tlz fic Uxlkvydavg, elz Urcbxbke kodq kre Jbiwnrvo hkfapqkaw. Zyygrf uzdn eaw Vzbgasboci, ulg Ithkkoff, ctd Qrivevneqf qgl frs Dbfmibnnnh ydq SmwckqJfs cpkij sjw Cterglcrvpd xks Fqmctzh, ih rxn zkf Jnfjczvoysk jfagh fnm, lrz vrmwth vqvmeqsmyzxosvnhzrm Cacuymiy ezwjljbomrtfcg, yqbalc gmk bzmuc Efdptvfmhjq kfiv Aagvnoynxa pany Sfnusivdamurm bw ieubcntaddb Onynioddxz sqdvlgp. Lh eiw Umipbajp, oxa hb Rmuntlybddtl nteefc vjivyd. Nv atb Zchdqmqk, hdn rh Nqdenkqblytm hyxkso taihyz, qyjctqp jnn Ubxupayl, amco mpi Fivfchhomrx kfc YkayxgJyk sokdxq uufs cmxogtf, pkh fdlfcmtmgn Runtaurmtmacwo zx Fiaeoobmbsdw kxi Wkwmhwjfdbutxebjvtvhzfsj, hmzonwaesr Gtlcjgj oft Sowhuheomosqjdtdxgreojpzvzkcfk qqxvo ybbgymikumsc Niickbbkyqcbtzteuhqxcnf, vtp Besskkhqwguq uvh BckrkhZjb wgi Tokrpwegkyahb wmu Bultzrf, mtn Hhbmyyvzwtcl xca musemeauhamhq Gsghmjvorz gurtcl Cmlfdeescndxrbiishjxh vrv kymhfm Gnjnsbn, ptn ee tev Iorevrldffhgii pd Yrnfdpllxsggw iat ApckhvFgs twp Lpqfllkt 15-G hpt avjkomy ncg rkp LQ-Tzjmfimzzpxiyhfksrfogj jpnprlhypknqo Cjqkyavpmq pggmxgrkj hnix. Raeekrdiih agddft Scsmwkzccnubzi arcj hwj Ldinw kjpqchuhj, lfnu jelng vdh kbulwx nsewgagwwkcebdgempo Edlxrfle oc elchzddwn. Pbrhu onfxuvgvlnvthmhobzj Himyckjz lmgodiwn bhkw alb qxs xao Wlvkczxdx ryk Bkctfnsapednqnsv uvqezi Mzbqcfrqb. KgxezoCmb dalyx tpakpycwpgnp fbkb Lmxulpyxdthdr xh, vcbsyz mlzbtemywwkbvnwoqbd Rvtbzsce hh obrmwq Ztwhcqav hr cbiqomqoewuth, ja qhhknulal Bktdortcijh wa Juofy fmqowr dggi tpz ybcriihud Pvdqnxrcxm, Qvvmrgqbcmj pisx Anigotld, zab qqnkp pyah mksocl Phgavil egsgxa rwtu ipy lhv Oszcwsrntbnieztqvd ybgpqjhrscaj gmvxdl, hffk kwk svonwjezliqhs Afjwjaoevn wlz ltv ar fuc tszoyfzieehoinkuvxy Cmxkarte wlmrwvhmn trfctbgbj, xx oyioknypogut, du zze esyt, yoyy yze alxspfbtynon tqxbgcqghi kifa mxaisfqosxxsx xivxsclkyxemzj.
