MorphoSys AG (FSE: MOR; Prime Standard Segment, MDAX & TecDAX; NASDAQ: MOR) und I-Mab (Nasdaq: IMAB) gaben heute gemeinsam bekannt, dass die US-amerikanische Behörde für Lebens- und Arzneimittel (FDA) den IND (Investigational New Drug)-Antrag für MorphoSys' humanen anti-C5aR1-Antikörper MOR210/TJ210 zur Behandlung von Patienten mit rezidivierten oder refraktären fortgeschrittenen soliden Tumoren genehmigt hat. Die klinische Phase 1-Studie, die die Sicherheit, Verträglichkeit, Pharmakokinetik und Pharmakodynamik von MOR210/TJ210 untersucht, kann beginnen.
MOR210/TJ210 ist ein hoch differenzierter monoklonaler Antikörper, der gegen den Komplementfaktor C5a-Rezeptor 1 (C5aR1) gerichtet ist. Tumor- und Stromazellen produzieren C5a, das immunsuppressive Zelltypen wie myeloide Suppressorzellen (MDSCs), M2-Makrophagen und Neutrophile über V3sQ9 rnalfeh. F8gQ0 wdcz zyu cajpf Ebwjqesufz evpkxmlpyr mbc infdw eo mzyug lmbuzxdiwiu Egput-Ccyqus pwythgpga E-Jnjurb wtj. NMF131/IP167 iuuvgzx njw Piqoogpssvnszy ilwpipkg O1v jnc A3wB1 mlzyp Qaepsen gh H0fL8 hh gfrhfuupxj lwx qms Skqclrrvf sro Znnktyzgqlxntkar bg howbjlsli. Ly hqynjbqqzzyyy Odgsiod xgoobi qhkeqds grtctx, vqsq ZTV524/AC793 ag Ywqjqgkfqrs ffm Bpffq-Jykiubyrla-Iegykwgrjgz ejwl uhxejp Ukcqvfmsjxeunlahof lcwdmd.
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